node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dfer_1048 | Dfer_4255 | Dfer_1048 | Dfer_4255 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: bfs:BF2850 putative folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.905 |
Dfer_1048 | Dfer_4811 | Dfer_1048 | Dfer_4811 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: bfs:BF2850 putative folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.912 |
Dfer_1048 | glyA | Dfer_1048 | Dfer_3814 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: bfs:BF2850 putative folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.670 |
Dfer_1048 | purH | Dfer_1048 | Dfer_3074 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: bfs:BF2850 putative folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | IMP cyclohydrolase; KEGG: chu:CHU_3309 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region. | 0.558 |
Dfer_1048 | thyA | Dfer_1048 | Dfer_5002 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: bfs:BF2850 putative folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.840 |
Dfer_2804 | Dfer_3669 | Dfer_2804 | Dfer_3669 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: formyltetrahydrofolate deformylase; PFAM: formyl transferase domain protein; KEGG: wsu:WS1475 formyltetrahydrofolate deformylase. | 0.920 |
Dfer_2804 | Dfer_4255 | Dfer_2804 | Dfer_4255 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.909 |
Dfer_2804 | Dfer_4811 | Dfer_2804 | Dfer_4811 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.909 |
Dfer_2804 | fmt | Dfer_2804 | Dfer_4814 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.926 |
Dfer_2804 | gcvT | Dfer_2804 | Dfer_4550 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.955 |
Dfer_2804 | glyA | Dfer_2804 | Dfer_3814 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.939 |
Dfer_2804 | purH | Dfer_2804 | Dfer_3074 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | IMP cyclohydrolase; KEGG: chu:CHU_3309 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region. | 0.915 |
Dfer_2804 | purN | Dfer_2804 | Dfer_2482 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Formyl transferase domain protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.920 |
Dfer_3669 | Dfer_2804 | Dfer_3669 | Dfer_2804 | TIGRFAM: formyltetrahydrofolate deformylase; PFAM: formyl transferase domain protein; KEGG: wsu:WS1475 formyltetrahydrofolate deformylase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.920 |
Dfer_3669 | Dfer_4255 | Dfer_3669 | Dfer_4255 | TIGRFAM: formyltetrahydrofolate deformylase; PFAM: formyl transferase domain protein; KEGG: wsu:WS1475 formyltetrahydrofolate deformylase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.903 |
Dfer_3669 | Dfer_4811 | Dfer_3669 | Dfer_4811 | TIGRFAM: formyltetrahydrofolate deformylase; PFAM: formyl transferase domain protein; KEGG: wsu:WS1475 formyltetrahydrofolate deformylase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.903 |
Dfer_3669 | gcvT | Dfer_3669 | Dfer_4550 | TIGRFAM: formyltetrahydrofolate deformylase; PFAM: formyl transferase domain protein; KEGG: wsu:WS1475 formyltetrahydrofolate deformylase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.928 |
Dfer_3669 | glyA | Dfer_3669 | Dfer_3814 | TIGRFAM: formyltetrahydrofolate deformylase; PFAM: formyl transferase domain protein; KEGG: wsu:WS1475 formyltetrahydrofolate deformylase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.931 |
Dfer_3669 | purH | Dfer_3669 | Dfer_3074 | TIGRFAM: formyltetrahydrofolate deformylase; PFAM: formyl transferase domain protein; KEGG: wsu:WS1475 formyltetrahydrofolate deformylase. | IMP cyclohydrolase; KEGG: chu:CHU_3309 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region. | 0.453 |
Dfer_3669 | purN | Dfer_3669 | Dfer_2482 | TIGRFAM: formyltetrahydrofolate deformylase; PFAM: formyl transferase domain protein; KEGG: wsu:WS1475 formyltetrahydrofolate deformylase. | Formyl transferase domain protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.939 |