STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Dfer_4563PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: bxe:Bxe_A4479 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (572 aa)    
Predicted Functional Partners:
Dfer_3681
KEGG: fps:FP0448 acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region.
  
 0.946
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
  
 0.921
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
  
 0.894
Dfer_3679
KEGG: aps:CFPG_336 ketol-acid reductoisomerase; TIGRFAM: ketol-acid reductoisomerase; PFAM: Acetohydroxy acid isomeroreductase catalytic domain protein; acetohydroxy acid isomeroreductase.
 
  
 0.891
Dfer_3680
TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: fps:FP0447 acetolactate synthase small subunit.
 
 
 0.889
Dfer_3673
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.870
Dfer_5479
PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II; KEGG: chu:CHU_3776 glutamate synthase (NADH) large subunit.
  
  
 0.870
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 0.790
Dfer_4562
PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: rrs:RoseRS_2882 short-chain dehydrogenase/reductase SDR.
     
 0.786
Dfer_3303
KEGG: chu:CHU_2817 branched chain amino acid aminotransferase; TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV.
 
 
 0.762
Your Current Organism:
Dyadobacter fermentans
NCBI taxonomy Id: 471854
Other names: D. fermentans DSM 18053, Dyadobacter fermentans DSM 18053, Dyadobacter fermentans str. DSM 18053, Dyadobacter fermentans strain DSM 18053
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