STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kuKu protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (346 aa)    
Predicted Functional Partners:
ACU95265.1
Hypothetical protein; TIGRFAM: DNA ligase D, 3'-phosphoesterase domain.
 
  
 0.942
ACU98455.1
PFAM: Eukaryotic and archaeal DNA primase small subunit; TIGRFAM: DNA polymerase LigD, polymerase domain; DNA ligase D.
 
  
 0.924
ACU97039.1
DNA polymerase LigD-like ligase domain-containing protein; PFAM: ATP dependent DNA ligase domain; ATP dependent DNA ligase C terminal region; TIGRFAM: DNA ligase D; DNA polymerase LigD, ligase domain.
 
  
 0.847
ACU98454.1
DNA ligase D/DNA polymerase LigD; PFAM: ATP dependent DNA ligase domain; ATP dependent DNA ligase C terminal region; TIGRFAM: DNA ligase D; DNA ligase D, 3'-phosphoesterase domain; DNA polymerase LigD, ligase domain.
 
  
 0.847
ACU95263.1
PFAM: HAMP domain; Adenylate and Guanylate cyclase catalytic domain.
       0.550
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
      
 0.476
ACU95564.1
PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA.
      
 0.473
ACU98401.1
Uncharacterized conserved protein; PFAM: Protein of unknown function DUF72.
 
    0.457
ACU95266.1
PFAM: Sigma-70 region 2; Sigma-70, region 4; Sigma-70 region 3; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; RNA polymerase sigma-70 factor, sigma-B/F/G subfamily.
       0.403
ACU95267.1
Hypothetical protein.
       0.403
Your Current Organism:
Saccharomonospora viridis
NCBI taxonomy Id: 471857
Other names: S. viridis DSM 43017, Saccharomonospora viridis ATCC 15386, Saccharomonospora viridis DSM 43017, Saccharomonospora viridis NCIB 9602, Saccharomonospora viridis NRRL B-3044, Saccharomonospora viridis str. DSM 43017, Saccharomonospora viridis strain DSM 43017
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