Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EDV05388.1RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (752 aa)    
Predicted Functional Partners:
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.916
EDV03172.1
RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
  
 
0.912
EDV04983.1
KEGG: bfs:BF3733 3.3e-69 putative nucleoside diphosphate kinase K00940; COG: COG0105 Nucleoside diphosphate kinase; Psort location: Cytoplasmic, score: 9.97.
    
 0.911
EDV07517.1
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
   
 
  0.903
nrdD
KEGG: bfs:BF3484 8.7e-165 putative anaerobic ribonucleoside-triphosphate reductase K00527; COG: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score: 8.96.
     
 0.902
EDV07268.1
Adenylate cyclase; KEGG: ava:Ava_1972 1.8e-31 putative adenylate cyclase family protein K01768; COG: COG2954 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.96.
     
  0.900
ribB
3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
 
 0.829
folE
GTP cyclohydrolase I; KEGG: bfs:BF3727 9.6e-95 folE, mtrA; GTP cyclohydrolase I K01495; COG: COG0302 GTP cyclohydrolase I; Psort location: Cytoplasmic, score: 8.96.
     
 0.803
EDV05387.1
Transglycosylase SLT domain protein; KEGG: bfs:BF0693 7.1e-186 putative lytic murein transglycosylase K08307; COG: COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains).
 
    0.764
EDV05389.1
COG: COG1664 Integral membrane protein CcmA involved in cell shape determination; Psort location: Cytoplasmic, score: 8.96.
       0.721
Your Current Organism:
Bacteroides intestinalis
NCBI taxonomy Id: 471870
Other names: B. intestinalis DSM 17393, Bacteroides intestinalis 341, Bacteroides intestinalis DSM 17393, Bacteroides intestinalis JCM 13265, Bacteroides intestinalis str. DSM 17393, Bacteroides intestinalis strain DSM 17393
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