Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EL18_01774A/G-specific DNA-adenine glycosylase; Adenine glycosylase active on G-A mispairs. (371 aa)    
Predicted Functional Partners:
sfsA
Sugar fermentation stimulation-like protein; Belongs to the SfsA family.
 
    0.933
EL18_02371
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 
 0.848
EL18_01775
Hydrolase.
       0.839
EL18_00893
Exodeoxyribonuclease III.
    
 0.789
EL18_02979
Exodeoxyribonuclease III Xth.
    
 0.789
EL18_00770
Endonuclease/exonuclease/phosphatase.
    
 0.783
EL18_01773
Hypothetical protein.
       0.659
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
    
 0.605
EL18_01772
DSBA oxidoreductase.
     
 0.557
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
 
   
 0.531
Your Current Organism:
Nitratireductor basaltis
NCBI taxonomy Id: 472175
Other names: JCM 14935, KCTC 22119, N. basaltis, Nitratireductor basaltis Kim et al. 2009, Nitratireductor sp. AZNO2, strain J3
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