| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LO55_4297 | glyA | LO55_4297 | LO55_4915 | Sda_mono: L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Aminotransferase class I and II family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.959 |
| LO55_4297 | ilvA | LO55_4297 | LO55_1005 | Sda_mono: L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.868 |
| LO55_4297 | ilvN | LO55_4297 | LO55_2922 | Sda_mono: L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Acolac_sm: acetolactate synthase, small subunit. | 0.675 |
| LO55_4297 | thrC | LO55_4297 | LO55_4296 | Sda_mono: L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | thrC: threonine synthase. | 0.670 |
| LO55_4297 | trpB | LO55_4297 | LO55_2722 | Sda_mono: L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.852 |
| LO55_4854 | LO55_507 | LO55_4854 | LO55_507 | Aminotransferase class IV family protein. | Thiamine pyrophosphate enzyme, central domain protein; Belongs to the TPP enzyme family. | 0.804 |
| LO55_4854 | ilvA | LO55_4854 | LO55_1005 | Aminotransferase class IV family protein. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.894 |
| LO55_4854 | ilvB | LO55_4854 | LO55_2921 | Aminotransferase class IV family protein. | Acolac_lg: acetolactate synthase, large subunit, biosynthetic type. | 0.753 |
| LO55_4854 | ilvN | LO55_4854 | LO55_2922 | Aminotransferase class IV family protein. | Acolac_sm: acetolactate synthase, small subunit. | 0.837 |
| LO55_4854 | leuB | LO55_4854 | LO55_2717 | Aminotransferase class IV family protein. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.443 |
| LO55_4854 | metH | LO55_4854 | LO55_683 | Aminotransferase class IV family protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.483 |
| LO55_4854 | thrC | LO55_4854 | LO55_4296 | Aminotransferase class IV family protein. | thrC: threonine synthase. | 0.666 |
| LO55_4854 | trpB | LO55_4854 | LO55_2722 | Aminotransferase class IV family protein. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.469 |
| LO55_507 | LO55_4854 | LO55_507 | LO55_4854 | Thiamine pyrophosphate enzyme, central domain protein; Belongs to the TPP enzyme family. | Aminotransferase class IV family protein. | 0.804 |
| LO55_507 | ilvA | LO55_507 | LO55_1005 | Thiamine pyrophosphate enzyme, central domain protein; Belongs to the TPP enzyme family. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.880 |
| LO55_507 | ilvB | LO55_507 | LO55_2921 | Thiamine pyrophosphate enzyme, central domain protein; Belongs to the TPP enzyme family. | Acolac_lg: acetolactate synthase, large subunit, biosynthetic type. | 0.928 |
| LO55_507 | ilvN | LO55_507 | LO55_2922 | Thiamine pyrophosphate enzyme, central domain protein; Belongs to the TPP enzyme family. | Acolac_sm: acetolactate synthase, small subunit. | 0.994 |
| LO55_507 | leuB | LO55_507 | LO55_2717 | Thiamine pyrophosphate enzyme, central domain protein; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.933 |
| LO55_507 | thrC | LO55_507 | LO55_4296 | Thiamine pyrophosphate enzyme, central domain protein; Belongs to the TPP enzyme family. | thrC: threonine synthase. | 0.406 |
| glyA | LO55_4297 | LO55_4915 | LO55_4297 | Aminotransferase class I and II family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Sda_mono: L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.959 |
