| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LO55_4352 | dut | LO55_4352 | LO55_2409 | Dihydrofolate reductase family protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | dUTP diphosphatase family protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.581 |
| LO55_4352 | folC | LO55_4352 | LO55_2726 | Dihydrofolate reductase family protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | folC: bifunctional FolC family protein; Belongs to the folylpolyglutamate synthase family. | 0.894 |
| LO55_4352 | folD | LO55_4352 | LO55_2337 | Dihydrofolate reductase family protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.613 |
| LO55_4352 | gcvP | LO55_4352 | LO55_3553 | Dihydrofolate reductase family protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.584 |
| LO55_4352 | glyA | LO55_4352 | LO55_4915 | Dihydrofolate reductase family protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminotransferase class I and II family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.910 |
| LO55_4352 | tdk | LO55_4352 | LO55_4450 | Dihydrofolate reductase family protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidine kinase family protein. | 0.664 |
| LO55_4352 | thyA | LO55_4352 | LO55_4351 | Dihydrofolate reductase family protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
| LO55_4352 | tmk | LO55_4352 | LO55_4235 | Dihydrofolate reductase family protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.621 |
| LO55_4387 | tdk | LO55_4387 | LO55_4450 | Hypothetical protein. | Thymidine kinase family protein. | 0.872 |
| LO55_4387 | thyA | LO55_4387 | LO55_4351 | Hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
| LO55_4387 | tmk | LO55_4387 | LO55_4235 | Hypothetical protein. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.859 |
| dut | LO55_4352 | LO55_2409 | LO55_4352 | dUTP diphosphatase family protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Dihydrofolate reductase family protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.581 |
| dut | tdk | LO55_2409 | LO55_4450 | dUTP diphosphatase family protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidine kinase family protein. | 0.963 |
| dut | thyA | LO55_2409 | LO55_4351 | dUTP diphosphatase family protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.973 |
| dut | tmk | LO55_2409 | LO55_4235 | dUTP diphosphatase family protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.938 |
| folC | LO55_4352 | LO55_2726 | LO55_4352 | folC: bifunctional FolC family protein; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase family protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.894 |
| folC | folD | LO55_2726 | LO55_2337 | folC: bifunctional FolC family protein; Belongs to the folylpolyglutamate synthase family. | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.768 |
| folC | glyA | LO55_2726 | LO55_4915 | folC: bifunctional FolC family protein; Belongs to the folylpolyglutamate synthase family. | Aminotransferase class I and II family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.695 |
| folC | lpdA | LO55_2726 | LO55_2340 | folC: bifunctional FolC family protein; Belongs to the folylpolyglutamate synthase family. | lipoamide_DH: dihydrolipoyl dehydrogenase. | 0.417 |
| folC | thyA | LO55_2726 | LO55_4351 | folC: bifunctional FolC family protein; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.894 |
