Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LO55_4633coA-transferase III family protein; Belongs to the CoA-transferase III family. (392 aa)    
Predicted Functional Partners:
LO55_4632
mmgE/PrpD family protein.
 
 
  0.916
LO55_4635
Hypothetical protein; N-terminal half of MaoC dehydratase family protein.
 
 
  0.888
LO55_4630
hpcH/HpaI aldolase/citrate lyase family protein; Belongs to the HpcH/HpaI aldolase family.
 
 
  0.881
LO55_4634
Hypothetical protein; acyl-CoA dehydrogenase, N-terminal domain protein.
 
 
  0.876
LO55_3128
Hypothetical protein; acyl-CoA dehydrogenase, N-terminal domain protein.
  
 
 0.792
icmF
Hypothetical protein; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
    
 0.777
LO55_1913
Hypothetical protein; acyl-CoA dehydrogenase, N-terminal domain protein.
 
  0.745
sucD
succinate-CoA ligase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
   
 0.741
sucC
succinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 0.720
LO55_1932
Malic enzyme, NAD binding domain protein; Belongs to the malic enzymes family.
     
 0.714
Your Current Organism:
Massilia timonae
NCBI taxonomy Id: 47229
Other names: CCUG 45783, CIP 105350, Janthinobacterium sp. R2-11, M. timonae, Massilia timonae La Scola et al. 2000 emend. Lindquist et al. 2003, Timone isolate, strain UR/MT95
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