Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (220 aa)    
Predicted Functional Partners:
pyrF
pyrF_sub2: orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily.
 
 
 0.999
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
 0.995
LO55_137
2Fe-2S iron-sulfur cluster binding domain protein.
  
 
 0.973
pyrC-2
Dihydroorotase; Multifunctional complex type domain protein; pyrC_multi: dihydroorotase, multifunctional complex type domain protein.
  
 
 0.960
LO55_2097
Phosphoribosyl transferase domain protein.
  
 
 0.955
pyrB
Asp_carb_tr: aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
  
 0.940
carA
CPSaseIIsmall: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family.
  
  
 0.936
carB
CPSaseII_lrg: carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family.
  
 
 0.921
LO55_218
D-ala D-ala ligase family protein.
  
 
 0.911
prs
Ribose-phosphate diphosphokinase family protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.907
Your Current Organism:
Massilia timonae
NCBI taxonomy Id: 47229
Other names: CCUG 45783, CIP 105350, Janthinobacterium sp. R2-11, M. timonae, Massilia timonae La Scola et al. 2000 emend. Lindquist et al. 2003, Timone isolate, strain UR/MT95
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.