STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OIJ18333.1Dihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (555 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.955
OIJ18336.1
Ketol-acid reductoisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.955
OIJ19813.1
Acetolactate synthase, large subunit, biosynthetic type; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.932
OIJ18334.1
Acetolactate synthase, large subunit, biosynthetic type; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.932
OIJ20498.1
4-amino-4-deoxychorismate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.901
OIJ18827.1
Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.896
OIJ20288.1
D-amino-acid transaminase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction.
  
 0.884
OIJ21214.1
Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.875
OIJ22227.1
Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.875
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 0.872
Your Current Organism:
Anaerobacillus alkalidiazotrophicus
NCBI taxonomy Id: 472963
Other names: A. alkalidiazotrophicus, Anaerobacillus alkalidiazotrophicus (Sorokin et al. 2008) Zavarzina et al. 2010, Bacillus alkalidiazotrophicus, Bacillus alkalidiazotrophicus Sorokin et al. 2008, DSM 22531, NCCB 100213, UNIQEM U377, strain MS 6
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