ENSNMLP00000001208 protein (Neogobius melanostomus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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Textmining

[Homology]

Score

ENSNMLP00000001208

annotation not available (146 aa)

Predicted Functional Partners:

ENSNMLP00000016159

0.594

ENSNMLP00000044594

0.538

ENSNMLP00000010665

0.482

ENSNMLP00000017813

0.482

ENSNMLP00000017815

0.482

ENSNMLP00000017817

0.482

ENSNMLP00000038645

0.476

ENSNMLP00000015037

0.469

ENSNMLP00000039417

0.469

ENSNMLP00000039418

0.469

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000001208	ENSNMLP00000010665	annotation not available	annotation not available	0.482
ENSNMLP00000001208	ENSNMLP00000015037	annotation not available	Interferon regulatory factor 7.	0.469
ENSNMLP00000001208	ENSNMLP00000016159	annotation not available	annotation not available	0.594
ENSNMLP00000001208	ENSNMLP00000017813	annotation not available	annotation not available	0.482
ENSNMLP00000001208	ENSNMLP00000017815	annotation not available	annotation not available	0.482
ENSNMLP00000001208	ENSNMLP00000017817	annotation not available	annotation not available	0.482
ENSNMLP00000001208	ENSNMLP00000038645	annotation not available	annotation not available	0.476
ENSNMLP00000001208	ENSNMLP00000039417	annotation not available	annotation not available	0.469
ENSNMLP00000001208	ENSNMLP00000039418	annotation not available	annotation not available	0.469
ENSNMLP00000001208	ENSNMLP00000044594	annotation not available	Interferon induced with helicase C domain 1.	0.538
ENSNMLP00000010665	ENSNMLP00000001208	annotation not available	annotation not available	0.482
ENSNMLP00000010665	ENSNMLP00000016159	annotation not available	annotation not available	0.596
ENSNMLP00000015037	ENSNMLP00000001208	Interferon regulatory factor 7.	annotation not available	0.469
ENSNMLP00000015037	ENSNMLP00000016159	Interferon regulatory factor 7.	annotation not available	0.929
ENSNMLP00000015037	ENSNMLP00000039417	Interferon regulatory factor 7.	annotation not available	0.617
ENSNMLP00000015037	ENSNMLP00000039418	Interferon regulatory factor 7.	annotation not available	0.617
ENSNMLP00000015037	ENSNMLP00000044594	Interferon regulatory factor 7.	Interferon induced with helicase C domain 1.	0.845
ENSNMLP00000016159	ENSNMLP00000001208	annotation not available	annotation not available	0.594
ENSNMLP00000016159	ENSNMLP00000010665	annotation not available	annotation not available	0.596
ENSNMLP00000016159	ENSNMLP00000015037	annotation not available	Interferon regulatory factor 7.	0.929

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.893

expected number of edges:

10

PPI enrichment p-value:

0.0337

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005223

Intracellular cGMP-activated cation channel activity

2 of 7

2.68

1.1

0.0101

GO:0005222

Intracellular cAMP-activated cation channel activity

2 of 9

2.57

1.09

0.0101

GO:0030553

cGMP binding

2 of 16

2.32

1.05

0.0117

GO:0015106

Bicarbonate transmembrane transporter activity

2 of 19

2.25

0.99

0.0146

GO:0099094

Ligand-gated cation channel activity

3 of 109

1.67

0.96

0.0109

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017071

Intracellular cyclic nucleotide activated cation channel complex

2 of 5

2.83

1.14

0.0088

GO:0036126

Sperm flagellum

3 of 98

1.71

0.9

0.0164

GO:0097225

Sperm midpiece

2 of 29

2.07

0.72

0.0459

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:24164424

(2013) Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating.

5 of 14

2.78

4.63

2.08e-09

PMID:33362798

(2020) Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System.

4 of 13

2.72

3.35

5.66e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19067

Mixed, incl. Bicarbonate transporters, and Ral GTPase-activating protein subunit alpha/beta, N-terminal domain

3 of 17

2.47

1.71

0.00069

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 11007

0.23

0.22

0.0282

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017071

Intracellular cyclic nucleotide activated cation channel complex

2 of 5

2.83

1.09

0.0106

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0406

Ion transport

4 of 286

1.37

0.97

0.0051

KW-0813

Transport

5 of 615

1.14

0.83

0.0051

KW-0407

Ion channel

3 of 198

1.41

0.77

0.0207

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000595

Cyclic nucleotide-binding domain

3 of 26

2.29

1.34

0.0032

IPR018490

Cyclic nucleotide-binding domain superfamily

3 of 29

2.24

1.33

0.0032

IPR014710

RmlC-like jelly roll fold

3 of 37

2.14

1.31

0.0032

IPR032406

Cyclic nucleotide-gated channel, C-terminal leucine zipper domain

2 of 4

2.93

1.2

0.0069

IPR018488

Cyclic nucleotide-binding, conserved site

2 of 13

2.42

0.82

0.0319

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00100

Cyclic nucleotide-monophosphate binding domain

3 of 26

2.29

1.78

0.00042

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