ENSNMLP00000001931 protein (Neogobius melanostomus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSNMLP00000001931

S100 calcium binding protein Z. (96 aa)

Predicted Functional Partners:

ENSNMLP00000015899

0.805

ENSNMLP00000036190

0.762

ENSNMLP00000038887

0.762

ENSNMLP00000002516

0.738

ENSNMLP00000004772

0.723

ENSNMLP00000001816

0.707

ENSNMLP00000011818

0.695

ENSNMLP00000017149

0.695

ENSNMLP00000043858

0.695

ENSNMLP00000026812

0.676

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000001816	ENSNMLP00000001931	Adaptor related protein complex 2 subunit sigma 1.	S100 calcium binding protein Z.	0.707
ENSNMLP00000001816	ENSNMLP00000015899	Adaptor related protein complex 2 subunit sigma 1.	Adaptor related protein complex 2 subunit mu 1a.	0.999
ENSNMLP00000001816	ENSNMLP00000036190	Adaptor related protein complex 2 subunit sigma 1.	Adaptor related protein complex 2 subunit beta 1.	0.990
ENSNMLP00000001816	ENSNMLP00000038887	Adaptor related protein complex 2 subunit sigma 1.	Adaptor related protein complex 1 subunit beta 1.	0.990
ENSNMLP00000001931	ENSNMLP00000001816	S100 calcium binding protein Z.	Adaptor related protein complex 2 subunit sigma 1.	0.707
ENSNMLP00000001931	ENSNMLP00000002516	S100 calcium binding protein Z.	annotation not available	0.738
ENSNMLP00000001931	ENSNMLP00000004772	S100 calcium binding protein Z.	S100 calcium binding protein A10a.	0.723
ENSNMLP00000001931	ENSNMLP00000011818	S100 calcium binding protein Z.	Annexin A2a.	0.695
ENSNMLP00000001931	ENSNMLP00000015899	S100 calcium binding protein Z.	Adaptor related protein complex 2 subunit mu 1a.	0.805
ENSNMLP00000001931	ENSNMLP00000017149	S100 calcium binding protein Z.	annotation not available	0.695
ENSNMLP00000001931	ENSNMLP00000026812	S100 calcium binding protein Z.	S100 calcium binding protein, beta (neural).	0.676
ENSNMLP00000001931	ENSNMLP00000036190	S100 calcium binding protein Z.	Adaptor related protein complex 2 subunit beta 1.	0.762
ENSNMLP00000001931	ENSNMLP00000038887	S100 calcium binding protein Z.	Adaptor related protein complex 1 subunit beta 1.	0.762
ENSNMLP00000001931	ENSNMLP00000043858	S100 calcium binding protein Z.	Annexin A1a.	0.695
ENSNMLP00000002516	ENSNMLP00000001931	annotation not available	S100 calcium binding protein Z.	0.738
ENSNMLP00000002516	ENSNMLP00000011818	annotation not available	Annexin A2a.	0.962
ENSNMLP00000002516	ENSNMLP00000017149	annotation not available	annotation not available	0.962
ENSNMLP00000002516	ENSNMLP00000043858	annotation not available	Annexin A1a.	0.951
ENSNMLP00000004772	ENSNMLP00000001931	S100 calcium binding protein A10a.	S100 calcium binding protein Z.	0.723
ENSNMLP00000004772	ENSNMLP00000011818	S100 calcium binding protein A10a.	Annexin A2a.	0.962

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

22

PPI enrichment p-value:

2.95e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 328

1.8

4.86

1.46e-16

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 159

2.07

6.34

2.75e-17

GO:0019843

rRNA binding

3 of 51

2.05

1.36

0.0024

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 184

2.01

5.98

5.37e-17

GO:0044391

Ribosomal subunit

4 of 135

1.75

1.71

0.00019

GO:0015935

Small ribosomal subunit

3 of 46

2.09

1.69

0.00050

GO:0022627

Cytosolic small ribosomal subunit

2 of 18

2.32

1.12

0.0086

GO:1990904

Ribonucleoprotein complex

5 of 555

1.23

1.04

0.0012

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28942070

(2017) Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison.

2 of 9

2.62

0.93

0.0209

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15235