ENSNMLP00000002827 protein (Neogobius melanostomus)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

ENSNMLP00000002827

Cathepsin K. (332 aa)

Predicted Functional Partners:

ENSNMLP00000016926

0.863

ENSNMLP00000004443

0.842

ENSNMLP00000037216

0.838

ENSNMLP00000012604

0.837

ENSNMLP00000022127

0.837

ENSNMLP00000007215

0.836

ENSNMLP00000039389

0.836

ENSNMLP00000024666

0.820

ENSNMLP00000024676

0.820

ENSNMLP00000022184

0.708

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000002827	ENSNMLP00000004443	Cathepsin K.	Cathepsin S, ortholog 1.	0.842
ENSNMLP00000002827	ENSNMLP00000007215	Cathepsin K.	BCL2 like 1.	0.836
ENSNMLP00000002827	ENSNMLP00000012604	Cathepsin K.	Baculoviral IAP repeat containing 5b.	0.837
ENSNMLP00000002827	ENSNMLP00000016926	Cathepsin K.	Baculoviral IAP repeat containing 2.	0.863
ENSNMLP00000002827	ENSNMLP00000022127	Cathepsin K.	Baculoviral IAP repeat containing 5a.	0.837
ENSNMLP00000002827	ENSNMLP00000022184	Cathepsin K.	Cathepsin 12.	0.708
ENSNMLP00000002827	ENSNMLP00000024666	Cathepsin K.	X-linked inhibitor of apoptosis.	0.820
ENSNMLP00000002827	ENSNMLP00000024676	Cathepsin K.	annotation not available	0.820
ENSNMLP00000002827	ENSNMLP00000037216	Cathepsin K.	BCL2 apoptosis regulator b.	0.838
ENSNMLP00000002827	ENSNMLP00000039389	Cathepsin K.	annotation not available	0.836
ENSNMLP00000004443	ENSNMLP00000002827	Cathepsin S, ortholog 1.	Cathepsin K.	0.842
ENSNMLP00000004443	ENSNMLP00000007215	Cathepsin S, ortholog 1.	BCL2 like 1.	0.835
ENSNMLP00000004443	ENSNMLP00000012604	Cathepsin S, ortholog 1.	Baculoviral IAP repeat containing 5b.	0.837
ENSNMLP00000004443	ENSNMLP00000016926	Cathepsin S, ortholog 1.	Baculoviral IAP repeat containing 2.	0.837
ENSNMLP00000004443	ENSNMLP00000022127	Cathepsin S, ortholog 1.	Baculoviral IAP repeat containing 5a.	0.837
ENSNMLP00000004443	ENSNMLP00000022184	Cathepsin S, ortholog 1.	Cathepsin 12.	0.503
ENSNMLP00000004443	ENSNMLP00000024666	Cathepsin S, ortholog 1.	X-linked inhibitor of apoptosis.	0.819
ENSNMLP00000004443	ENSNMLP00000024676	Cathepsin S, ortholog 1.	annotation not available	0.819
ENSNMLP00000004443	ENSNMLP00000037216	Cathepsin S, ortholog 1.	BCL2 apoptosis regulator b.	0.845
ENSNMLP00000004443	ENSNMLP00000039389	Cathepsin S, ortholog 1.	annotation not available	0.835

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.878

expected number of edges:

13

PPI enrichment p-value:

1.84e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022900

Electron transport chain

6 of 73

2.27

4.09

3.68e-09

GO:0042775

Mitochondrial ATP synthesis coupled electron transport

5 of 35

2.51

4.01

1.80e-08

GO:0032981

Mitochondrial respiratory chain complex I assembly

5 of 44

2.41

3.9

2.08e-08

GO:0045333

Cellular respiration

6 of 110

2.09

3.58

1.80e-08

GO:0019646

Aerobic electron transport chain

4 of 30

2.48

3.22

6.88e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

7 of 38

2.62

6.78

3.66e-14

GO:0009055

Electron transfer activity

7 of 51

2.49

6.34

1.21e-13

GO:0003954

NADH dehydrogenase activity

6 of 26

2.71

6.19

1.20e-12

GO:0008137

NADH dehydrogenase (ubiquinone) activity

5 of 23

2.69

5.02

2.68e-10

GO:0016491

Oxidoreductase activity

9 of 742

1.43

2.47

3.47e-10

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005746

Mitochondrial respirasome

8 of 48

2.57

7.85

9.10e-17

GO:0098803

Respiratory chain complex

8 of 52

2.54

7.77

9.10e-17

GO:1990204

Oxidoreductase complex

8 of 75

2.38

7.02

6.30e-16

GO:0098800

Inner mitochondrial membrane protein complex

8 of 99

2.26

6.37

4.15e-15

GO:0005747

Mitochondrial respiratory chain complex I

6 of 31

2.64

6.2

7.54e-13

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33201259

(2021) Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role.

3 of 21

2.51

1.62

0.0010

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3506

NADH dehydrogenase complex, and Respiratory chain complex III

8 of 38

2.67

8.16

5.40e-17

CL:3510

NADH dehydrogenase complex

5 of 25

2.65

4.96

3.07e-10

CL:3566

Mitochondrial respiratory chain complex III, and Peptidase M16, N-terminal

2 of 5

2.95

1.61

0.0012

CL:3545

Mitochondrial electron transport, NADH to ubiquinone

2 of 6

2.87

1.56

0.0015

CL:4828

Tryptophan catabolism

2 of 11

2.61

1.31

0.0040

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

amj00190

Oxidative phosphorylation

8 of 90

2.3

6.68

1.26e-15

amj01100

Metabolic pathways

10 of 1264

1.25

1.96

1.14e-10

amj00380

Tryptophan metabolism

2 of 40

2.05

1.09

0.0085

amj04260

Cardiac muscle contraction

2 of 62

1.86

0.94

0.0149

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-611105

Respiratory electron transport

8 of 88

2.31

6.37

1.05e-14

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

8 of 110

2.21

5.94

2.89e-14

MAP-6799198

Complex I biogenesis

6 of 44

2.49

5.5

9.59e-12

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

8 of 162

2.04

5.07

3.83e-13

MAP-1430728

Metabolism

11 of 2271

1.04

1.35

1.37e-09

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

10 of 11323

0.3

0.25

0.0241

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

7 of 47

2.52

6.48

8.05e-14

GOCC:0005747

Mitochondrial respiratory chain complex I

4 of 19

2.67

3.65

1.44e-07

GOCC:0005743

Mitochondrial inner membrane

5 of 168

1.82

2.52

1.56e-06

GOCC:0032117

Horsetail-astral microtubule array

2 of 3

3.17

2.12

0.00015

GOCC:1902495

Transmembrane transporter complex

4 of 178

1.7

1.78

9.25e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0830

Ubiquinone

6 of 45

2.48

5.51

8.61e-12

KW-0679

Respiratory chain

3 of 9

2.87

3.07

2.36e-06

KW-0496

Mitochondrion

3 of 116

1.76

1.37

0.0014

KW-0999

Mitochondrion inner membrane

2 of 38

2.07

1.08

0.0091

KW-0349

Heme

2 of 73

1.79

0.81

0.0268

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