ENSNMLP00000004829 protein (Neogobius melanostomus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSNMLP00000004829

annotation not available (409 aa)

Predicted Functional Partners:

ENSNMLP00000034002

0.932

ENSNMLP00000021265

0.863

ENSNMLP00000027073

0.863

ENSNMLP00000025341

0.683

ENSNMLP00000014475

0.667

ENSNMLP00000016926

0.667

ENSNMLP00000024666

0.667

ENSNMLP00000024676

0.667

ENSNMLP00000024480

0.634

ENSNMLP00000035323

0.595

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000004829	ENSNMLP00000014475	annotation not available	Baculoviral IAP repeat containing 7.	0.667
ENSNMLP00000004829	ENSNMLP00000016926	annotation not available	Baculoviral IAP repeat containing 2.	0.667
ENSNMLP00000004829	ENSNMLP00000021265	annotation not available	HESX homeobox 1.	0.863
ENSNMLP00000004829	ENSNMLP00000024480	annotation not available	Receptor-interacting serine-threonine kinase 4.	0.634
ENSNMLP00000004829	ENSNMLP00000024666	annotation not available	X-linked inhibitor of apoptosis.	0.667
ENSNMLP00000004829	ENSNMLP00000024676	annotation not available	annotation not available	0.667
ENSNMLP00000004829	ENSNMLP00000025341	annotation not available	Mindbomb E3 ubiquitin protein ligase 2.	0.683
ENSNMLP00000004829	ENSNMLP00000027073	annotation not available	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	0.863
ENSNMLP00000004829	ENSNMLP00000034002	annotation not available	Apoptotic peptidase activating factor 1.	0.932
ENSNMLP00000004829	ENSNMLP00000035323	annotation not available	Tnfrsf1a-associated via death domain.	0.595
ENSNMLP00000014475	ENSNMLP00000004829	Baculoviral IAP repeat containing 7.	annotation not available	0.667
ENSNMLP00000014475	ENSNMLP00000016926	Baculoviral IAP repeat containing 7.	Baculoviral IAP repeat containing 2.	0.839
ENSNMLP00000014475	ENSNMLP00000024480	Baculoviral IAP repeat containing 7.	Receptor-interacting serine-threonine kinase 4.	0.675
ENSNMLP00000014475	ENSNMLP00000024666	Baculoviral IAP repeat containing 7.	X-linked inhibitor of apoptosis.	0.925
ENSNMLP00000014475	ENSNMLP00000024676	Baculoviral IAP repeat containing 7.	annotation not available	0.922
ENSNMLP00000014475	ENSNMLP00000034002	Baculoviral IAP repeat containing 7.	Apoptotic peptidase activating factor 1.	0.812
ENSNMLP00000014475	ENSNMLP00000035323	Baculoviral IAP repeat containing 7.	Tnfrsf1a-associated via death domain.	0.967
ENSNMLP00000016926	ENSNMLP00000004829	Baculoviral IAP repeat containing 2.	annotation not available	0.667
ENSNMLP00000016926	ENSNMLP00000014475	Baculoviral IAP repeat containing 2.	Baculoviral IAP repeat containing 7.	0.839
ENSNMLP00000016926	ENSNMLP00000024480	Baculoviral IAP repeat containing 2.	Receptor-interacting serine-threonine kinase 4.	0.675

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.927

expected number of edges:

12

PPI enrichment p-value:

4.11e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015813

L-glutamate transmembrane transport

8 of 34

2.68

8.21

4.55e-17

GO:0015804

Neutral amino acid transport

8 of 64

2.41

7.02

1.02e-15

GO:0098657

Import into cell

10 of 158

2.11

6.5

3.39e-17

GO:0140009

L-aspartate import across plasma membrane

5 of 8

3.11

6.13

5.03e-12

GO:0098712

L-glutamate import across plasma membrane

5 of 12

2.93

5.77

1.70e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015501

Glutamate:sodium symporter activity

7 of 14

3.01

8.7

3.97e-17

GO:0015370

Solute:sodium symporter activity

10 of 102

2.3

8.03

1.67e-19

GO:0005313

L-glutamate transmembrane transporter activity

7 of 25

2.76

7.79

6.81e-16

GO:0015175

Neutral amino acid transmembrane transporter activity

7 of 62

2.37

6.14

9.50e-14

GO:0008509

Anion transmembrane transporter activity

10 of 358

1.76

4.43

2.94e-15

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045202

Synapse

10 of 1052

1.29

2.02

6.44e-10

GO:0098793

Presynapse

5 of 385

1.43

1.51

8.55e-05

GO:0005887

Integral component of plasma membrane

9 of 1342

1.14

1.44

1.90e-07

GO:0032809

Neuronal cell body membrane

2 of 23

2.25

1.19

0.0060

GO:0045121

Membrane raft

3 of 138

1.65

1.13

0.0042

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:39553

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

10 of 20

3.01

12.83

1.55e-25

CL:39555

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

8 of 15

3.04

10.29

3.08e-20

CL:39557

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

7 of 10

3.16

9.3

4.84e-18

CL:39559

D-amino acid transport, and Dopamine:sodium symporter activity

3 of 5

3.09

3.14

1.97e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

7 of 47

2.49

6.68

1.89e-14

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-210500

Glutamate Neurotransmitter Release Cycle

7 of 52

2.44

6.21

1.54e-13

MAP-112310

Neurotransmitter release cycle

7 of 110

2.12

4.8

1.11e-11

MAP-425393

Transport of inorganic cations/anions and amino acids/oligopeptides

8 of 188

1.94

4.51

2.46e-12

MAP-425407

SLC-mediated transmembrane transport

10 of 424

1.69

3.85

1.10e-13

MAP-112315

Transmission across Chemical Synapses

8 of 444

1.57

2.79

1.04e-09

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 11939

0.28

0.25

0.0081

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005887

Integral component of plasma membrane

5 of 403

1.41

1.19

0.0012

GOCC:0032809

Neuronal cell body membrane

2 of 17

2.38

1.15

0.0077

GOCC:0005886

Plasma membrane

8 of 2464

0.82

0.67

0.0012

GOCC:0016020

Membrane

10 of 4744

0.64

0.51

0.0012

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0769

Symport

10 of 60

2.53

10.07

1.58e-22

KW-1133

Transmembrane helix

11 of 6003

0.58

0.5

5.45e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00375

Sodium:dicarboxylate symporter family

7 of 17

2.93

8.11

3.96e-16

PF00209

Sodium:neurotransmitter symporter family

3 of 44

2.15

1.49

0.0014

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