ENSNMLP00000008190 protein (Neogobius melanostomus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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Experiments

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[Homology]

Score

ENSNMLP00000008190

Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila). (446 aa)

Predicted Functional Partners:

ENSNMLP00000012382

0.841

ENSNMLP00000007467

0.593

ENSNMLP00000024480

0.552

ENSNMLP00000012380

0.531

ENSNMLP00000016805

0.518

SPOP

0.510

ENSNMLP00000043865

0.510

YTHDC2

0.490

ENSNMLP00000010494

0.487

ENSNMLP00000005050

0.468

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSNMLP00000005050	ENSNMLP00000008190	ENSNMLP00000005050	ENSNMLP00000008190	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	0.468
ENSNMLP00000007467	ENSNMLP00000008190	ENSNMLP00000007467	ENSNMLP00000008190	annotation not available	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	0.593
ENSNMLP00000007467	ENSNMLP00000016805	ENSNMLP00000007467	ENSNMLP00000016805	annotation not available	BRCA1 associated RING domain 1.	0.474
ENSNMLP00000007467	ENSNMLP00000024480	ENSNMLP00000007467	ENSNMLP00000024480	annotation not available	Receptor-interacting serine-threonine kinase 4.	0.954
ENSNMLP00000008190	ENSNMLP00000005050	ENSNMLP00000008190	ENSNMLP00000005050	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.	0.468
ENSNMLP00000008190	ENSNMLP00000007467	ENSNMLP00000008190	ENSNMLP00000007467	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	annotation not available	0.593
ENSNMLP00000008190	ENSNMLP00000010494	ENSNMLP00000008190	ENSNMLP00000010494	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	POU domain, class 5, transcription factor 3.	0.487
ENSNMLP00000008190	ENSNMLP00000012380	ENSNMLP00000008190	ENSNMLP00000012380	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	annotation not available	0.531
ENSNMLP00000008190	ENSNMLP00000012382	ENSNMLP00000008190	ENSNMLP00000012382	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	annotation not available	0.841
ENSNMLP00000008190	ENSNMLP00000016805	ENSNMLP00000008190	ENSNMLP00000016805	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	BRCA1 associated RING domain 1.	0.518
ENSNMLP00000008190	ENSNMLP00000024480	ENSNMLP00000008190	ENSNMLP00000024480	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	Receptor-interacting serine-threonine kinase 4.	0.552
ENSNMLP00000008190	ENSNMLP00000043865	ENSNMLP00000008190	ENSNMLP00000043865	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	Speckle type BTB/POZ protein like b.	0.510
ENSNMLP00000008190	SPOP	ENSNMLP00000008190	ENSNMLP00000012914	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	Speckle type BTB/POZ protein.	0.510
ENSNMLP00000008190	YTHDC2	ENSNMLP00000008190	ENSNMLP00000012904	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	YTH domain containing 2.	0.490
ENSNMLP00000010494	ENSNMLP00000008190	ENSNMLP00000010494	ENSNMLP00000008190	POU domain, class 5, transcription factor 3.	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	0.487
ENSNMLP00000012380	ENSNMLP00000008190	ENSNMLP00000012380	ENSNMLP00000008190	annotation not available	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	0.531
ENSNMLP00000012380	ENSNMLP00000012382	ENSNMLP00000012380	ENSNMLP00000012382	annotation not available	annotation not available	0.999
ENSNMLP00000012382	ENSNMLP00000008190	ENSNMLP00000012382	ENSNMLP00000008190	annotation not available	Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila).	0.841
ENSNMLP00000012382	ENSNMLP00000012380	ENSNMLP00000012382	ENSNMLP00000012380	annotation not available	annotation not available	0.999
ENSNMLP00000016805	ENSNMLP00000007467	ENSNMLP00000016805	ENSNMLP00000007467	BRCA1 associated RING domain 1.	annotation not available	0.474

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

13

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

7 of 14

2.2

4.77

4.05e-11

GO:0000162

Tryptophan biosynthetic process

4 of 4

2.5

3.23

7.12e-07

GO:0046417

Chorismate metabolic process

3 of 9

2.02

1.85

0.00020

GO:0008652

Cellular amino acid biosynthetic process

7 of 99

1.35

1.81

7.12e-07

GO:0019438

Aromatic compound biosynthetic process

10 of 203

1.19

1.71

2.70e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016829

Lyase activity

6 of 121

1.2

1.08

0.00060

GO:0016835

Carbon-oxygen lyase activity

4 of 46

1.44

1.03

0.0042

GO:0004834

Tryptophan synthase activity

2 of 2

2.5

1.03

0.0133

GO:0004106

Chorismate mutase activity

2 of 2

2.5

1.03

0.0133

GO:0016836

Hydro-lyase activity

3 of 37

1.41

0.7

0.0319

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1270

0.4

0.28

0.0388

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30808357

(2019) Metabolic engineering of microorganisms for production of aromatic compounds.

4 of 8

2.2

2.52

1.05e-05

PMID:34584039

(2021) Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production.

2 of 2

2.5

1.07

0.0109

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1391

Aromatic amino acid biosynthesis, and Anthranilate synthase/para-aminobenzoate synthase like domain

10 of 15

2.32

7.99

3.90e-19

CL:1393

Tryptophan biosynthesis

5 of 6

2.42

4.23

4.38e-09

CL:1407

Chorismate metabolic process

3 of 7

2.13

1.88

0.00022

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pha00400

Phenylalanine, tyrosine and tryptophan biosynthesis

8 of 18

2.15

5.67

5.08e-14

pha01230

Biosynthesis of amino acids

8 of 113

1.35

2.04

1.36e-08

pha00790

Folate biosynthesis

3 of 24

1.6

1.25

0.0018

pha01110

Biosynthesis of secondary metabolites

8 of 287

0.95

0.97

1.13e-05

pha01100

Metabolic pathways

8 of 632

0.6

0.46

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

7 of 12

2.27

5.34

3.03e-12

KW-0822

Tryptophan biosynthesis

5 of 5

2.5

4.45

2.07e-09

KW-0456

Lyase

9 of 133

1.33

2.1

1.40e-09

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04715

Anthranilate synthase component I, N terminal region

2 of 2

2.5

0.84

0.0299

PF00425

Chorismate binding enzyme

2 of 2

2.5

0.84

0.0299

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00830

Chorismate mutase type II

2 of 2

2.5

1.18

0.0068

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