ENSNMLP00000008668 protein (Neogobius melanostomus)

Nodes:

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white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSNMLP00000008668

annotation not available (106 aa)

Predicted Functional Partners:

ENSNMLP00000010128

0.796

ENSNMLP00000041528

0.618

ENSNMLP00000030587

0.569

ENSNMLP00000007845

0.414

ENSNMLP00000016518

0.414

ENSNMLP00000018059

0.414

ENSNMLP00000025422

0.414

ENSNMLP00000038553

0.414

ENSNMLP00000043154

0.414

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000007845	ENSNMLP00000008668	Tight junction associated protein 1 (peripheral).	annotation not available	0.414
ENSNMLP00000007845	ENSNMLP00000010128	Tight junction associated protein 1 (peripheral).	DOT1-like histone H3K79 methyltransferase.	0.550
ENSNMLP00000008668	ENSNMLP00000007845	annotation not available	Tight junction associated protein 1 (peripheral).	0.414
ENSNMLP00000008668	ENSNMLP00000010128	annotation not available	DOT1-like histone H3K79 methyltransferase.	0.796
ENSNMLP00000008668	ENSNMLP00000016518	annotation not available	MLLT3 super elongation complex subunit.	0.414
ENSNMLP00000008668	ENSNMLP00000018059	annotation not available	annotation not available	0.414
ENSNMLP00000008668	ENSNMLP00000025422	annotation not available	Si:dkey-174m14.3.	0.414
ENSNMLP00000008668	ENSNMLP00000030587	annotation not available	Eukaryotic translation elongation factor 1 gamma.	0.569
ENSNMLP00000008668	ENSNMLP00000038553	annotation not available	YEATS domain containing 4.	0.414
ENSNMLP00000008668	ENSNMLP00000041528	annotation not available	valyl-tRNA synthetase 1.	0.618
ENSNMLP00000008668	ENSNMLP00000043154	annotation not available	MLLT1 super elongation complex subunit a.	0.414
ENSNMLP00000010128	ENSNMLP00000007845	DOT1-like histone H3K79 methyltransferase.	Tight junction associated protein 1 (peripheral).	0.550
ENSNMLP00000010128	ENSNMLP00000008668	DOT1-like histone H3K79 methyltransferase.	annotation not available	0.796
ENSNMLP00000010128	ENSNMLP00000016518	DOT1-like histone H3K79 methyltransferase.	MLLT3 super elongation complex subunit.	0.815
ENSNMLP00000010128	ENSNMLP00000018059	DOT1-like histone H3K79 methyltransferase.	annotation not available	0.550
ENSNMLP00000010128	ENSNMLP00000025422	DOT1-like histone H3K79 methyltransferase.	Si:dkey-174m14.3.	0.550
ENSNMLP00000010128	ENSNMLP00000038553	DOT1-like histone H3K79 methyltransferase.	YEATS domain containing 4.	0.572
ENSNMLP00000010128	ENSNMLP00000043154	DOT1-like histone H3K79 methyltransferase.	MLLT1 super elongation complex subunit a.	0.815
ENSNMLP00000016518	ENSNMLP00000008668	MLLT3 super elongation complex subunit.	annotation not available	0.414
ENSNMLP00000016518	ENSNMLP00000010128	MLLT3 super elongation complex subunit.	DOT1-like histone H3K79 methyltransferase.	0.815

page 1 of 2

Network Stats

number of nodes:

7

number of edges:

13

average node degree:

3.71

avg. local clustering coefficient:

0.924

expected number of edges:

6

PPI enrichment p-value:

0.00911

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015986

Proton motive force-driven ATP synthesis

9 of 21

2.89

10.62

2.13e-21

GO:1902600

Proton transmembrane transport

11 of 103

2.29

8.67

9.50e-22

GO:0046034

ATP metabolic process

10 of 92

2.3

8.07

1.05e-19

GO:0042776

Proton motive force-driven mitochondrial ATP synthesis

5 of 11

2.92

5.76

1.73e-11

GO:0007035

Vacuolar acidification

2 of 19

2.28

1.17

0.0067

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015078

Proton transmembrane transporter activity

11 of 104

2.29

8.78

3.44e-22

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

4 of 11

2.82

4.12

2.16e-08

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

2 of 28

2.12

0.85

0.0257

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

9 of 15

3.04

11.77

3.05e-23

GO:0016469

Proton-transporting two-sector ATPase complex

11 of 49

2.61

11.67

7.93e-26

GO:0033177

Proton-transporting two-sector ATPase complex, proton-transporting domain

6 of 22

2.7

6.4

3.95e-13

GO:0000276

Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

5 of 9

3.01

6.1

4.70e-12

GO:0033178

Proton-transporting two-sector ATPase complex, catalytic domain

4 of 19

2.58

3.94

3.15e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:25925

Formation of ATP by chemiosmotic coupling

9 of 17

2.99

11.09

4.89e-22

CL:25932

Mitochondrial proton-transporting ATP synthase complex

7 of 7

3.26

9.39

4.52e-18

CL:31860

Vacuolar proton-transporting V-type ATPase, V1 domain

2 of 6

2.78

1.37

0.0032

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

11 of 189

2.03

6.87

1.39e-20

map01100

Metabolic pathways

11 of 2959

0.83

0.9

6.98e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163210

Formation of ATP by chemiosmotic coupling

9 of 19

2.94

11.04

4.23e-22

MAP-8949613

Cristae formation

9 of 30

2.74

10.05

6.48e-21

MAP-1592230

Mitochondrial biogenesis

9 of 54

2.48

8.54

4.82e-19

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

9 of 130

2.1

6.09

6.21e-16

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

9 of 191

1.93

5.06

1.42e-14

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001630

Right ventricle

5 of 133

1.84

3.0

5.70e-08

BTO:0001703

Right atrium

2 of 102

1.55

1.17

0.0025

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016469

Proton-transporting two-sector ATPase complex

11 of 42

2.68

12.19

2.10e-26

GOCC:0045259

Proton-transporting ATP synthase complex

9 of 25

2.82

10.53

1.46e-21

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

6 of 15

2.86

6.79

1.36e-13

GOCC:0005753

Mitochondrial proton-transporting ATP synthase complex

5 of 8

3.06

6.09

5.40e-12

GOCC:0000276

Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

4 of 4

3.26

5.02

7.24e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

8 of 25

2.77

9.09

1.19e-18

KW-0066

ATP synthesis

3 of 5

3.04

3.41

5.89e-07

KW-0139

CF(1)

2 of 4

2.96

1.96

0.00028

KW-0496

Mitochondrion

3 of 158

1.54

1.07

0.0046

KW-0999

Mitochondrion inner membrane

2 of 51

1.86

0.9

0.0183

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05873

ATP synthase D chain, mitochondrial (ATP5H)

2 of 2

3.26

1.36

0.0036

PF00006

ATP synthase alpha/beta family, nucleotide-binding domain

2 of 4

2.96

1.3

0.0045

PF02874

ATP synthase alpha/beta family, beta-barrel domain

2 of 6

2.78

1.24

0.0056

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