ENSNMLP00000009380 protein (Neogobius melanostomus)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ENSNMLP00000009380

RanBP-type and C3HC4-type zinc finger containing 1. (445 aa)

Predicted Functional Partners:

ENSNMLP00000008443

0.971

ENSNMLP00000023848

0.971

ENSNMLP00000032748

0.971

ENSNMLP00000034807

0.971

ENSNMLP00000032713

0.956

ENSNMLP00000041849

0.952

ENSNMLP00000001704

0.947

ENSNMLP00000042820

0.912

ENSNMLP00000008533

0.887

ENSNMLP00000010067

0.887

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000001704	ENSNMLP00000008443	Ubiquitin B.	annotation not available	0.925
ENSNMLP00000001704	ENSNMLP00000008533	Ubiquitin B.	Tnf receptor-associated factor 2b.	0.789
ENSNMLP00000001704	ENSNMLP00000009380	Ubiquitin B.	RanBP-type and C3HC4-type zinc finger containing 1.	0.947
ENSNMLP00000001704	ENSNMLP00000010067	Ubiquitin B.	annotation not available	0.801
ENSNMLP00000001704	ENSNMLP00000023848	Ubiquitin B.	annotation not available	0.925
ENSNMLP00000001704	ENSNMLP00000032713	Ubiquitin B.	annotation not available	0.963
ENSNMLP00000001704	ENSNMLP00000032748	Ubiquitin B.	annotation not available	0.925
ENSNMLP00000001704	ENSNMLP00000034807	Ubiquitin B.	Tumor necrosis factor receptor superfamily, member 1a.	0.733
ENSNMLP00000001704	ENSNMLP00000041849	Ubiquitin B.	OTU deubiquitinase with linear linkage specificity a.	0.975
ENSNMLP00000001704	ENSNMLP00000042820	Ubiquitin B.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.862
ENSNMLP00000008443	ENSNMLP00000001704	annotation not available	Ubiquitin B.	0.925
ENSNMLP00000008443	ENSNMLP00000008533	annotation not available	Tnf receptor-associated factor 2b.	0.858
ENSNMLP00000008443	ENSNMLP00000009380	annotation not available	RanBP-type and C3HC4-type zinc finger containing 1.	0.971
ENSNMLP00000008443	ENSNMLP00000010067	annotation not available	annotation not available	0.855
ENSNMLP00000008443	ENSNMLP00000032713	annotation not available	annotation not available	0.935
ENSNMLP00000008443	ENSNMLP00000034807	annotation not available	Tumor necrosis factor receptor superfamily, member 1a.	0.959
ENSNMLP00000008443	ENSNMLP00000041849	annotation not available	OTU deubiquitinase with linear linkage specificity a.	0.981
ENSNMLP00000008443	ENSNMLP00000042820	annotation not available	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.895
ENSNMLP00000008533	ENSNMLP00000001704	Tnf receptor-associated factor 2b.	Ubiquitin B.	0.789
ENSNMLP00000008533	ENSNMLP00000008443	Tnf receptor-associated factor 2b.	annotation not available	0.858

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.878

expected number of edges:

13

PPI enrichment p-value:

1.84e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022900

Electron transport chain

6 of 73

2.27

4.09

3.68e-09

GO:0042775

Mitochondrial ATP synthesis coupled electron transport

5 of 35

2.51

4.01

1.80e-08

GO:0032981

Mitochondrial respiratory chain complex I assembly

5 of 44

2.41

3.9

2.08e-08

GO:0045333

Cellular respiration

6 of 110

2.09

3.58

1.80e-08

GO:0019646

Aerobic electron transport chain

4 of 30

2.48

3.22

6.88e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

7 of 38

2.62

6.78

3.66e-14

GO:0009055

Electron transfer activity

7 of 51

2.49

6.34

1.21e-13

GO:0003954

NADH dehydrogenase activity

6 of 26

2.71

6.19

1.20e-12

GO:0008137

NADH dehydrogenase (ubiquinone) activity

5 of 23

2.69

5.02

2.68e-10

GO:0016491

Oxidoreductase activity

9 of 742

1.43

2.47

3.47e-10

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005746

Mitochondrial respirasome

8 of 48

2.57

7.85

9.10e-17

GO:0098803

Respiratory chain complex

8 of 52

2.54

7.77

9.10e-17

GO:1990204

Oxidoreductase complex

8 of 75

2.38

7.02

6.30e-16

GO:0098800

Inner mitochondrial membrane protein complex

8 of 99

2.26

6.37

4.15e-15

GO:0005747

Mitochondrial respiratory chain complex I

6 of 31

2.64

6.2

7.54e-13

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33201259

(2021) Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role.

3 of 21

2.51

1.62

0.0010

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3506

NADH dehydrogenase complex, and Respiratory chain complex III

8 of 38

2.67

8.16

5.40e-17

CL:3510

NADH dehydrogenase complex

5 of 25

2.65

4.96

3.07e-10

CL:3566

Mitochondrial respiratory chain complex III, and Peptidase M16, N-terminal

2 of 5

2.95

1.61

0.0012

CL:3545

Mitochondrial electron transport, NADH to ubiquinone

2 of 6

2.87

1.56

0.0015

CL:4828

Tryptophan catabolism

2 of 11

2.61

1.31

0.0040

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

amj00190

Oxidative phosphorylation

8 of 90

2.3

6.68

1.26e-15

amj01100

Metabolic pathways

10 of 1264

1.25

1.96

1.14e-10

amj00380

Tryptophan metabolism

2 of 40

2.05

1.09

0.0085

amj04260

Cardiac muscle contraction

2 of 62

1.86

0.94

0.0149

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-611105

Respiratory electron transport

8 of 88

2.31

6.37

1.05e-14

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

8 of 110

2.21

5.94

2.89e-14

MAP-6799198

Complex I biogenesis

6 of 44

2.49

5.5

9.59e-12

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

8 of 162

2.04

5.07

3.83e-13

MAP-1430728

Metabolism

11 of 2271

1.04

1.35

1.37e-09

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

10 of 11323

0.3

0.25

0.0241

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

7 of 47

2.52

6.48

8.05e-14

GOCC:0005747

Mitochondrial respiratory chain complex I

4 of 19

2.67

3.65

1.44e-07

GOCC:0005743

Mitochondrial inner membrane

5 of 168

1.82

2.52

1.56e-06

GOCC:0032117

Horsetail-astral microtubule array

2 of 3

3.17

2.12

0.00015

GOCC:1902495

Transmembrane transporter complex

4 of 178

1.7

1.78

9.25e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0830

Ubiquinone

6 of 45

2.48

5.51

8.61e-12

KW-0679

Respiratory chain

3 of 9

2.87

3.07

2.36e-06

KW-0496

Mitochondrion

3 of 116

1.76

1.37

0.0014

KW-0999

Mitochondrion inner membrane

2 of 38

2.07

1.08

0.0091

KW-0349

Heme

2 of 73

1.79

0.81

0.0268

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