ENSNMLP00000010493 protein (Neogobius melanostomus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSNMLP00000010493

Ring finger protein 2. (342 aa)

Predicted Functional Partners:

ENSNMLP00000014626

0.990

ENSNMLP00000017381

0.990

ENSNMLP00000023617

0.990

ENSNMLP00000027615

0.990

ENSNMLP00000043413

0.990

ENSNMLP00000001942

0.963

ENSNMLP00000009247

0.963

PCGF3

0.959

ENSNMLP00000000904

0.952

ENSNMLP00000008657

0.952

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSNMLP00000000904	ENSNMLP00000001942	ENSNMLP00000000904	ENSNMLP00000001942	Polycomb group ring finger 6.	Bmi1 polycomb ring finger oncogene 1a.	0.859
ENSNMLP00000000904	ENSNMLP00000008657	ENSNMLP00000000904	ENSNMLP00000008657	Polycomb group ring finger 6.	annotation not available	0.880
ENSNMLP00000000904	ENSNMLP00000009247	ENSNMLP00000000904	ENSNMLP00000009247	Polycomb group ring finger 6.	Polycomb group ring finger 5a.	0.879
ENSNMLP00000000904	ENSNMLP00000010493	ENSNMLP00000000904	ENSNMLP00000010493	Polycomb group ring finger 6.	Ring finger protein 2.	0.952
ENSNMLP00000000904	ENSNMLP00000014626	ENSNMLP00000000904	ENSNMLP00000014626	Polycomb group ring finger 6.	annotation not available	0.953
ENSNMLP00000000904	ENSNMLP00000017381	ENSNMLP00000000904	ENSNMLP00000017381	Polycomb group ring finger 6.	Lysine (K)-specific demethylase 2Bb.	0.955
ENSNMLP00000000904	ENSNMLP00000023617	ENSNMLP00000000904	ENSNMLP00000023617	Polycomb group ring finger 6.	annotation not available	0.955
ENSNMLP00000000904	ENSNMLP00000027615	ENSNMLP00000000904	ENSNMLP00000027615	Polycomb group ring finger 6.	Lysine (K)-specific demethylase 2Ab.	0.955
ENSNMLP00000000904	ENSNMLP00000043413	ENSNMLP00000000904	ENSNMLP00000043413	Polycomb group ring finger 6.	Lysine (K)-specific demethylase 2Ba.	0.955
ENSNMLP00000000904	PCGF3	ENSNMLP00000000904	ENSNMLP00000044438	Polycomb group ring finger 6.	Polycomb group ring finger 3.	0.890
ENSNMLP00000001942	ENSNMLP00000000904	ENSNMLP00000001942	ENSNMLP00000000904	Bmi1 polycomb ring finger oncogene 1a.	Polycomb group ring finger 6.	0.859
ENSNMLP00000001942	ENSNMLP00000009247	ENSNMLP00000001942	ENSNMLP00000009247	Bmi1 polycomb ring finger oncogene 1a.	Polycomb group ring finger 5a.	0.870
ENSNMLP00000001942	ENSNMLP00000010493	ENSNMLP00000001942	ENSNMLP00000010493	Bmi1 polycomb ring finger oncogene 1a.	Ring finger protein 2.	0.963
ENSNMLP00000001942	ENSNMLP00000014626	ENSNMLP00000001942	ENSNMLP00000014626	Bmi1 polycomb ring finger oncogene 1a.	annotation not available	0.954
ENSNMLP00000001942	ENSNMLP00000017381	ENSNMLP00000001942	ENSNMLP00000017381	Bmi1 polycomb ring finger oncogene 1a.	Lysine (K)-specific demethylase 2Bb.	0.954
ENSNMLP00000001942	ENSNMLP00000023617	ENSNMLP00000001942	ENSNMLP00000023617	Bmi1 polycomb ring finger oncogene 1a.	annotation not available	0.954
ENSNMLP00000001942	ENSNMLP00000027615	ENSNMLP00000001942	ENSNMLP00000027615	Bmi1 polycomb ring finger oncogene 1a.	Lysine (K)-specific demethylase 2Ab.	0.954
ENSNMLP00000001942	ENSNMLP00000043413	ENSNMLP00000001942	ENSNMLP00000043413	Bmi1 polycomb ring finger oncogene 1a.	Lysine (K)-specific demethylase 2Ba.	0.954
ENSNMLP00000001942	PCGF3	ENSNMLP00000001942	ENSNMLP00000044438	Bmi1 polycomb ring finger oncogene 1a.	Polycomb group ring finger 3.	0.884
ENSNMLP00000008657	ENSNMLP00000000904	ENSNMLP00000008657	ENSNMLP00000000904	annotation not available	Polycomb group ring finger 6.	0.880

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

22

PPI enrichment p-value:

2.95e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 328

1.8

4.86

1.46e-16

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 159

2.07

6.34

2.75e-17

GO:0019843

rRNA binding

3 of 51

2.05

1.36

0.0024

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 184

2.01

5.98

5.37e-17

GO:0044391

Ribosomal subunit

4 of 135

1.75

1.71

0.00019

GO:0015935

Small ribosomal subunit

3 of 46

2.09

1.69

0.00050

GO:0022627

Cytosolic small ribosomal subunit

2 of 18

2.32

1.12

0.0086

GO:1990904

Ribonucleoprotein complex

5 of 555

1.23

1.04

0.0012

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28942070

(2017) Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison.

2 of 9

2.62

0.93

0.0209

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15235