ENSNMLP00000011143 protein (Neogobius melanostomus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ENSNMLP00000011143

Si:dkey-183j2.10. (490 aa)

Predicted Functional Partners:

ENSNMLP00000015356

0.771

CACNG2

0.767

ENSNMLP00000009813

0.761

ENSNMLP00000007428

0.618

ENSNMLP00000009347

0.562

ENSNMLP00000025147

0.535

ENSNMLP00000031864

0.530

ENSNMLP00000001224

0.490

ENSNMLP00000001275

0.490

ENSNMLP00000017873

0.447

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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... protein annotations:

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACNG2	ENSNMLP00000001224	ENSNMLP00000039537	ENSNMLP00000001224	Calcium voltage-gated channel auxiliary subunit gamma 2.	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	0.815
CACNG2	ENSNMLP00000001275	ENSNMLP00000039537	ENSNMLP00000001275	Calcium voltage-gated channel auxiliary subunit gamma 2.	annotation not available	0.815
CACNG2	ENSNMLP00000009813	ENSNMLP00000039537	ENSNMLP00000009813	Calcium voltage-gated channel auxiliary subunit gamma 2.	Sodium channel, voltage-gated, type IV, alpha, a.	0.471
CACNG2	ENSNMLP00000011143	ENSNMLP00000039537	ENSNMLP00000011143	Calcium voltage-gated channel auxiliary subunit gamma 2.	Si:dkey-183j2.10.	0.767
CACNG2	ENSNMLP00000025147	ENSNMLP00000039537	ENSNMLP00000025147	Calcium voltage-gated channel auxiliary subunit gamma 2.	annotation not available	0.984
CACNG2	ENSNMLP00000031864	ENSNMLP00000039537	ENSNMLP00000031864	Calcium voltage-gated channel auxiliary subunit gamma 2.	Glutamate receptor, ionotropic, AMPA 2b.	0.984
ENSNMLP00000001224	CACNG2	ENSNMLP00000001224	ENSNMLP00000039537	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	Calcium voltage-gated channel auxiliary subunit gamma 2.	0.815
ENSNMLP00000001224	ENSNMLP00000007428	ENSNMLP00000001224	ENSNMLP00000007428	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	annotation not available	0.693
ENSNMLP00000001224	ENSNMLP00000011143	ENSNMLP00000001224	ENSNMLP00000011143	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	Si:dkey-183j2.10.	0.490
ENSNMLP00000001224	ENSNMLP00000025147	ENSNMLP00000001224	ENSNMLP00000025147	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	annotation not available	0.828
ENSNMLP00000001224	ENSNMLP00000031864	ENSNMLP00000001224	ENSNMLP00000031864	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	Glutamate receptor, ionotropic, AMPA 2b.	0.828
ENSNMLP00000001275	CACNG2	ENSNMLP00000001275	ENSNMLP00000039537	annotation not available	Calcium voltage-gated channel auxiliary subunit gamma 2.	0.815
ENSNMLP00000001275	ENSNMLP00000007428	ENSNMLP00000001275	ENSNMLP00000007428	annotation not available	annotation not available	0.967
ENSNMLP00000001275	ENSNMLP00000011143	ENSNMLP00000001275	ENSNMLP00000011143	annotation not available	Si:dkey-183j2.10.	0.490
ENSNMLP00000001275	ENSNMLP00000025147	ENSNMLP00000001275	ENSNMLP00000025147	annotation not available	annotation not available	0.828
ENSNMLP00000001275	ENSNMLP00000031864	ENSNMLP00000001275	ENSNMLP00000031864	annotation not available	Glutamate receptor, ionotropic, AMPA 2b.	0.828
ENSNMLP00000007428	ENSNMLP00000001224	ENSNMLP00000007428	ENSNMLP00000001224	annotation not available	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	0.693
ENSNMLP00000007428	ENSNMLP00000001275	ENSNMLP00000007428	ENSNMLP00000001275	annotation not available	annotation not available	0.967
ENSNMLP00000007428	ENSNMLP00000011143	ENSNMLP00000007428	ENSNMLP00000011143	annotation not available	Si:dkey-183j2.10.	0.618
ENSNMLP00000007428	ENSNMLP00000025147	ENSNMLP00000007428	ENSNMLP00000025147	annotation not available	annotation not available	0.564

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.881

expected number of edges:

11

PPI enrichment p-value:

0.00205

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000228

Positive regulation of pancreatic A cell differentiation

2 of 2

3.31

1.11

0.0102

GO:2000252

Negative regulation of feeding behavior

2 of 6

2.84

1.0

0.0159

GO:0021952

Central nervous system projection neuron axonogenesis

2 of 8

2.71

0.99

0.0159

GO:0003309

Type B pancreatic cell differentiation

2 of 17

2.38

0.8

0.0349

GO:1900181

Negative regulation of protein localization to nucleus

2 of 21

2.29

0.75

0.0430

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:24336

RFX DNA-binding domain, and Tuberculosis

4 of 5

3.22

4.27

1.72e-08

CL:376

CaMK IV-mediated phosphorylation of CREB, and Tubulin/FtsZ family, GTPase domain

2 of 5

2.91

1.54

0.0016

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05152

Tuberculosis

2 of 12

2.53

1.32

0.0038

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-74749

Signal attenuation

2 of 6

2.84

1.11

0.0100

MAP-442729

CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde

2 of 6

2.84

1.11

0.0100

MAP-111932

CaMK IV-mediated phosphorylation of CREB

2 of 6

2.84

1.11

0.0100

MAP-74713

IRS activation

2 of 8

2.71

1.1

0.0100

MAP-422085

Synthesis, secretion, and deacylation of Ghrelin

2 of 15

2.44

1.09

0.0100

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0313

Glucose metabolism

2 of 4

3.01

1.64

0.0011

KW-0372

Hormone

2 of 30

2.14

0.93

0.0185

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00537

Domain in the Doublecortin (DCX) gene product

2 of 7

2.77

1.25

0.0053

SM00078

Insulin / insulin-like growth factor / relaxin family.

2 of 10

2.61

1.25

0.0053

SM00220

Serine/Threonine protein kinases, catalytic domain

3 of 241

1.41

0.64

0.0441

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