CYP46A1-2 protein (Neogobius melanostomus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CYP46A1-2

Cytochrome P450 family 46 subfamily A member 1. (506 aa)

Predicted Functional Partners:

ENSNMLP00000007814

0.837

ENSNMLP00000018258

0.836

ENSNMLP00000041787

0.833

ENSNMLP00000002015

0.805

ENSNMLP00000032917

0.805

ENSNMLP00000003663

0.801

ENSNMLP00000022349

0.779

ENSNMLP00000026437

0.779

HSD17B7

0.779

ENSNMLP00000009951

0.746

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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structured XML interaction data, according to the 'PSI-MI' data standard

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP46A1-2	ENSNMLP00000002015	ENSNMLP00000011497	ENSNMLP00000002015	Cytochrome P450 family 46 subfamily A member 1.	Sulfite oxidase.	0.805
CYP46A1-2	ENSNMLP00000003663	ENSNMLP00000011497	ENSNMLP00000003663	Cytochrome P450 family 46 subfamily A member 1.	Cytochrome b5 reductase 4.	0.801
CYP46A1-2	ENSNMLP00000007814	ENSNMLP00000011497	ENSNMLP00000007814	Cytochrome P450 family 46 subfamily A member 1.	Acetylserotonin O-methyltransferase-like.	0.837
CYP46A1-2	ENSNMLP00000009951	ENSNMLP00000011497	ENSNMLP00000009951	Cytochrome P450 family 46 subfamily A member 1.	annotation not available	0.746
CYP46A1-2	ENSNMLP00000018258	ENSNMLP00000011497	ENSNMLP00000018258	Cytochrome P450 family 46 subfamily A member 1.	Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase).	0.836
CYP46A1-2	ENSNMLP00000022349	ENSNMLP00000011497	ENSNMLP00000022349	Cytochrome P450 family 46 subfamily A member 1.	Hydroxysteroid (17-beta) dehydrogenase 7.	0.779
CYP46A1-2	ENSNMLP00000026437	ENSNMLP00000011497	ENSNMLP00000026437	Cytochrome P450 family 46 subfamily A member 1.	Squalene epoxidase a.	0.779
CYP46A1-2	ENSNMLP00000032917	ENSNMLP00000011497	ENSNMLP00000032917	Cytochrome P450 family 46 subfamily A member 1.	annotation not available	0.805
CYP46A1-2	ENSNMLP00000041787	ENSNMLP00000011497	ENSNMLP00000041787	Cytochrome P450 family 46 subfamily A member 1.	Phospholipase A2, group IVAb (cytosolic, calcium-dependent).	0.833
CYP46A1-2	HSD17B7	ENSNMLP00000011497	ENSNMLP00000030937	Cytochrome P450 family 46 subfamily A member 1.	Hydroxysteroid 17-beta dehydrogenase 7.	0.779
ENSNMLP00000002015	CYP46A1-2	ENSNMLP00000002015	ENSNMLP00000011497	Sulfite oxidase.	Cytochrome P450 family 46 subfamily A member 1.	0.805
ENSNMLP00000002015	ENSNMLP00000003663	ENSNMLP00000002015	ENSNMLP00000003663	Sulfite oxidase.	Cytochrome b5 reductase 4.	0.941
ENSNMLP00000002015	ENSNMLP00000007814	ENSNMLP00000002015	ENSNMLP00000007814	Sulfite oxidase.	Acetylserotonin O-methyltransferase-like.	0.538
ENSNMLP00000002015	ENSNMLP00000032917	ENSNMLP00000002015	ENSNMLP00000032917	Sulfite oxidase.	annotation not available	0.896
ENSNMLP00000003663	CYP46A1-2	ENSNMLP00000003663	ENSNMLP00000011497	Cytochrome b5 reductase 4.	Cytochrome P450 family 46 subfamily A member 1.	0.801
ENSNMLP00000003663	ENSNMLP00000002015	ENSNMLP00000003663	ENSNMLP00000002015	Cytochrome b5 reductase 4.	Sulfite oxidase.	0.941
ENSNMLP00000003663	ENSNMLP00000009951	ENSNMLP00000003663	ENSNMLP00000009951	Cytochrome b5 reductase 4.	annotation not available	0.476
ENSNMLP00000003663	ENSNMLP00000018258	ENSNMLP00000003663	ENSNMLP00000018258	Cytochrome b5 reductase 4.	Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase).	0.574
ENSNMLP00000003663	ENSNMLP00000026437	ENSNMLP00000003663	ENSNMLP00000026437	Cytochrome b5 reductase 4.	Squalene epoxidase a.	0.934
ENSNMLP00000003663	ENSNMLP00000032917	ENSNMLP00000003663	ENSNMLP00000032917	Cytochrome b5 reductase 4.	annotation not available	0.941

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

22

PPI enrichment p-value:

2.95e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 328

1.8

4.86

1.46e-16

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 159

2.07

6.34

2.75e-17

GO:0019843

rRNA binding

3 of 51

2.05

1.36

0.0024

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 184

2.01

5.98

5.37e-17

GO:0044391

Ribosomal subunit

4 of 135

1.75

1.71

0.00019

GO:0015935

Small ribosomal subunit

3 of 46

2.09

1.69

0.00050

GO:0022627

Cytosolic small ribosomal subunit

2 of 18

2.32

1.12

0.0086

GO:1990904

Ribonucleoprotein complex

5 of 555

1.23

1.04

0.0012

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28942070

(2017) Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison.

2 of 9

2.62

0.93

0.0209

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15235