ENSNMLP00000012321 protein (Neogobius melanostomus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSNMLP00000012321

annotation not available (247 aa)

Predicted Functional Partners:

GRIN3A

0.787

ENSNMLP00000039707

0.776

ENSNMLP00000005958

0.758

ENSNMLP00000024275

0.749

ENSNMLP00000017026

0.732

ENSNMLP00000025147

0.543

ENSNMLP00000031864

0.543

ENSNMLP00000016799

0.527

ENSNMLP00000001224

0.499

ENSNMLP00000001275

0.499

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSNMLP00000001224	ENSNMLP00000005958	ENSNMLP00000001224	ENSNMLP00000005958	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	Calcium channel, voltage-dependent, gamma subunit 7b.	0.819
ENSNMLP00000001224	ENSNMLP00000012321	ENSNMLP00000001224	ENSNMLP00000012321	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	annotation not available	0.499
ENSNMLP00000001224	ENSNMLP00000017026	ENSNMLP00000001224	ENSNMLP00000017026	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	annotation not available	0.802
ENSNMLP00000001224	ENSNMLP00000024275	ENSNMLP00000001224	ENSNMLP00000024275	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	Glutamate receptor, ionotropic, N-methyl-D-aspartate 3Ba.	0.966
ENSNMLP00000001224	ENSNMLP00000025147	ENSNMLP00000001224	ENSNMLP00000025147	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	annotation not available	0.828
ENSNMLP00000001224	ENSNMLP00000031864	ENSNMLP00000001224	ENSNMLP00000031864	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	Glutamate receptor, ionotropic, AMPA 2b.	0.828
ENSNMLP00000001224	GRIN3A	ENSNMLP00000001224	ENSNMLP00000008262	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	Glutamate ionotropic receptor NMDA type subunit 3A.	0.966
ENSNMLP00000001275	ENSNMLP00000005958	ENSNMLP00000001275	ENSNMLP00000005958	annotation not available	Calcium channel, voltage-dependent, gamma subunit 7b.	0.819
ENSNMLP00000001275	ENSNMLP00000012321	ENSNMLP00000001275	ENSNMLP00000012321	annotation not available	annotation not available	0.499
ENSNMLP00000001275	ENSNMLP00000017026	ENSNMLP00000001275	ENSNMLP00000017026	annotation not available	annotation not available	0.802
ENSNMLP00000001275	ENSNMLP00000024275	ENSNMLP00000001275	ENSNMLP00000024275	annotation not available	Glutamate receptor, ionotropic, N-methyl-D-aspartate 3Ba.	0.966
ENSNMLP00000001275	ENSNMLP00000025147	ENSNMLP00000001275	ENSNMLP00000025147	annotation not available	annotation not available	0.828
ENSNMLP00000001275	ENSNMLP00000031864	ENSNMLP00000001275	ENSNMLP00000031864	annotation not available	Glutamate receptor, ionotropic, AMPA 2b.	0.828
ENSNMLP00000001275	GRIN3A	ENSNMLP00000001275	ENSNMLP00000008262	annotation not available	Glutamate ionotropic receptor NMDA type subunit 3A.	0.966
ENSNMLP00000005958	ENSNMLP00000001224	ENSNMLP00000005958	ENSNMLP00000001224	Calcium channel, voltage-dependent, gamma subunit 7b.	Glutamate receptor, ionotropic, N-methyl D-aspartate 1a.	0.819
ENSNMLP00000005958	ENSNMLP00000001275	ENSNMLP00000005958	ENSNMLP00000001275	Calcium channel, voltage-dependent, gamma subunit 7b.	annotation not available	0.819
ENSNMLP00000005958	ENSNMLP00000012321	ENSNMLP00000005958	ENSNMLP00000012321	Calcium channel, voltage-dependent, gamma subunit 7b.	annotation not available	0.758
ENSNMLP00000005958	ENSNMLP00000024275	ENSNMLP00000005958	ENSNMLP00000024275	Calcium channel, voltage-dependent, gamma subunit 7b.	Glutamate receptor, ionotropic, N-methyl-D-aspartate 3Ba.	0.836
ENSNMLP00000005958	ENSNMLP00000025147	ENSNMLP00000005958	ENSNMLP00000025147	Calcium channel, voltage-dependent, gamma subunit 7b.	annotation not available	0.892
ENSNMLP00000005958	ENSNMLP00000031864	ENSNMLP00000005958	ENSNMLP00000031864	Calcium channel, voltage-dependent, gamma subunit 7b.	Glutamate receptor, ionotropic, AMPA 2b.	0.892

page 1 of 4

Network Stats

number of nodes:

10

number of edges:

45

average node degree:

9

avg. local clustering coefficient:

1

expected number of edges:

9

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007399

Nervous system development

7 of 1365

0.9

0.49

0.0416

GO:0007275

Multicellular organism development

9 of 2894

0.68

0.4

0.0416

GO:0032502

Developmental process

10 of 3929

0.59

0.36

0.0416

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0047179

Platelet-activating factor acetyltransferase activity

2 of 4

2.89

0.99

0.0166

GO:0003847

1-alkyl-2-acetylglycerophosphocholine esterase activity

2 of 6

2.71

0.98

0.0166

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008247

1-alkyl-2-acetylglycerophosphocholine esterase complex

2 of 3

3.01

1.24

0.0058

GO:0016580

Sin3 complex

2 of 9

2.54

0.99

0.0159

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31382

Mixed, incl. Secretory granule maturation, and Geranylgeranyl diphosphate metabolic process

3 of 6

2.89

2.3

6.31e-05

CL:6840

Sin3-type complex, and SAP30 zinc-finger

2 of 10

2.49

0.83

0.0312

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008247

1-alkyl-2-acetylglycerophosphocholine esterase complex

2 of 4

2.89

1.11

0.0100

GOCC:0016580

Sin3 complex

2 of 9

2.54

0.95

0.0183

GOCC:0005634

Nucleus

8 of 2999

0.61

0.37

0.0414

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0539

Nucleus

7 of 1483

0.86

0.65

0.0037

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16879

C-terminal domain of Sin3a protein

2 of 2

3.19

1.29

0.0048

PF02671

Paired amphipathic helix repeat

2 of 2

3.19

1.29

0.0048

PF13472

GDSL-like Lipase/Acylhydrolase family

2 of 3

3.01

1.28

0.0048

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00761

Histone deacetylase (HDAC) interacting

2 of 2

3.19

1.54

0.0017

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