ENSNMLP00000013809 protein (Neogobius melanostomus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSNMLP00000013809

Bone morphogenetic protein 1b. (953 aa)

Predicted Functional Partners:

ENSNMLP00000042080

0.840

ENSNMLP00000036111

0.702

ENSNMLP00000041701

0.702

ENSNMLP00000019793

0.509

ENSNMLP00000019797

0.509

ENSNMLP00000021966

0.470

ENSNMLP00000026350

0.470

ENSNMLP00000013768

0.456

ENSNMLP00000036883

0.456

ENSNMLP00000036884

0.456

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000013768	ENSNMLP00000013809	Collagen, type XI, alpha 1a.	Bone morphogenetic protein 1b.	0.456
ENSNMLP00000013768	ENSNMLP00000036111	Collagen, type XI, alpha 1a.	Procollagen C-endopeptidase enhancer a.	0.485
ENSNMLP00000013768	ENSNMLP00000041701	Collagen, type XI, alpha 1a.	Procollagen C-endopeptidase enhancer 2b.	0.485
ENSNMLP00000013809	ENSNMLP00000013768	Bone morphogenetic protein 1b.	Collagen, type XI, alpha 1a.	0.456
ENSNMLP00000013809	ENSNMLP00000019793	Bone morphogenetic protein 1b.	annotation not available	0.509
ENSNMLP00000013809	ENSNMLP00000019797	Bone morphogenetic protein 1b.	annotation not available	0.509
ENSNMLP00000013809	ENSNMLP00000021966	Bone morphogenetic protein 1b.	Prolylcarboxypeptidase (angiotensinase C).	0.470
ENSNMLP00000013809	ENSNMLP00000026350	Bone morphogenetic protein 1b.	Dipeptidyl-peptidase 7.	0.470
ENSNMLP00000013809	ENSNMLP00000036111	Bone morphogenetic protein 1b.	Procollagen C-endopeptidase enhancer a.	0.702
ENSNMLP00000013809	ENSNMLP00000036883	Bone morphogenetic protein 1b.	annotation not available	0.456
ENSNMLP00000013809	ENSNMLP00000036884	Bone morphogenetic protein 1b.	annotation not available	0.456
ENSNMLP00000013809	ENSNMLP00000041701	Bone morphogenetic protein 1b.	Procollagen C-endopeptidase enhancer 2b.	0.702
ENSNMLP00000013809	ENSNMLP00000042080	Bone morphogenetic protein 1b.	Chordin.	0.840
ENSNMLP00000019793	ENSNMLP00000013809	annotation not available	Bone morphogenetic protein 1b.	0.509
ENSNMLP00000019797	ENSNMLP00000013809	annotation not available	Bone morphogenetic protein 1b.	0.509
ENSNMLP00000021966	ENSNMLP00000013809	Prolylcarboxypeptidase (angiotensinase C).	Bone morphogenetic protein 1b.	0.470
ENSNMLP00000026350	ENSNMLP00000013809	Dipeptidyl-peptidase 7.	Bone morphogenetic protein 1b.	0.470
ENSNMLP00000036111	ENSNMLP00000013768	Procollagen C-endopeptidase enhancer a.	Collagen, type XI, alpha 1a.	0.485
ENSNMLP00000036111	ENSNMLP00000013809	Procollagen C-endopeptidase enhancer a.	Bone morphogenetic protein 1b.	0.702
ENSNMLP00000036111	ENSNMLP00000036883	Procollagen C-endopeptidase enhancer a.	annotation not available	0.485

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.676

expected number of edges:

12

PPI enrichment p-value:

0.00143

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007605

Sensory perception of sound

8 of 73

2.35

6.34

2.47e-14

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050811

GABA receptor binding

5 of 9

3.06

5.59

4.84e-11

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042383

Sarcolemma

3 of 75

1.91

1.23

0.0039

GO:0098858

Actin-based cell projection

3 of 127

1.69

1.0

0.0090

GO:0005886

Plasma membrane

10 of 5087

0.61

0.46

0.0036

GO:0016020

Membrane

11 of 8862

0.41

0.31

0.0090

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1044

Mixed, incl. Vestibular reflex, and GABA receptor binding

6 of 11

3.05

6.92

1.39e-13

CL:1047

Mixed, incl. TMC domain, and GABA receptor binding

5 of 6

3.23

6.02

9.79e-12

CL:32823

Mixed, incl. Catenin complex, and GABA receptor binding

4 of 55

2.17

2.37

2.05e-05

CL:32915

GABA receptor binding, and Cluster of actin-based cell projections

2 of 6

2.84

1.61

0.0012

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9709957

Sensory Perception

10 of 289

1.85

4.87

2.53e-15

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000042

Animal

11 of 13707

0.22

0.21

0.0368

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0060077

Inhibitory synapse

5 of 17

2.78

5.01

3.60e-10

GOCC:0032421

Stereocilium bundle

4 of 46

2.25

2.69

5.05e-06

GOCC:0032420

Stereocilium

3 of 34

2.26

1.9

0.00024

GOCC:0030054

Cell junction

6 of 905

1.13

1.03

0.00048

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10242

Lipoma HMGIC fusion partner-like protein

5 of 10

3.01

5.53

5.85e-11

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00054

EF-hand, calcium binding motif

3 of 149

1.62

0.74

0.0325

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