ENSNMLP00000014510 protein (Neogobius melanostomus)

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ENSNMLP00000014510

Uridine-cytidine kinase 1-like 1b. (554 aa)

Predicted Functional Partners:

ENSNMLP00000013206

0.978

ENSNMLP00000003100

0.942

ENSNMLP00000010135

0.942

ENSNMLP00000042449

0.942

ENSNMLP00000042450

0.942

ENSNMLP00000038367

0.888

ENSNMLP00000042437

0.887

ENSNMLP00000018317

0.880

ENSNMLP00000033544

0.880

ENSNMLP00000039562

0.880

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000003100	ENSNMLP00000010135	Wu:fi36a10.	annotation not available	0.878
ENSNMLP00000003100	ENSNMLP00000014510	Wu:fi36a10.	Uridine-cytidine kinase 1-like 1b.	0.942
ENSNMLP00000003100	ENSNMLP00000018317	Wu:fi36a10.	MET proto-oncogene, receptor tyrosine kinase.	0.573
ENSNMLP00000003100	ENSNMLP00000033544	Wu:fi36a10.	Macrophage stimulating 1 receptor a.	0.573
ENSNMLP00000003100	ENSNMLP00000039562	Wu:fi36a10.	annotation not available	0.573
ENSNMLP00000003100	ENSNMLP00000042437	Wu:fi36a10.	Uridine monophosphate synthetase.	0.470
ENSNMLP00000003100	ENSNMLP00000042449	Wu:fi36a10.	Membrane associated guanylate kinase, WW and PDZ domain containing 3b.	0.863
ENSNMLP00000003100	ENSNMLP00000042450	Wu:fi36a10.	annotation not available	0.862
ENSNMLP00000010135	ENSNMLP00000003100	annotation not available	Wu:fi36a10.	0.878
ENSNMLP00000010135	ENSNMLP00000014510	annotation not available	Uridine-cytidine kinase 1-like 1b.	0.942
ENSNMLP00000010135	ENSNMLP00000018317	annotation not available	MET proto-oncogene, receptor tyrosine kinase.	0.573
ENSNMLP00000010135	ENSNMLP00000033544	annotation not available	Macrophage stimulating 1 receptor a.	0.573
ENSNMLP00000010135	ENSNMLP00000039562	annotation not available	annotation not available	0.573
ENSNMLP00000010135	ENSNMLP00000042437	annotation not available	Uridine monophosphate synthetase.	0.470
ENSNMLP00000010135	ENSNMLP00000042449	annotation not available	Membrane associated guanylate kinase, WW and PDZ domain containing 3b.	0.884
ENSNMLP00000010135	ENSNMLP00000042450	annotation not available	annotation not available	0.878
ENSNMLP00000013206	ENSNMLP00000014510	Uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae).	Uridine-cytidine kinase 1-like 1b.	0.978
ENSNMLP00000013206	ENSNMLP00000042437	Uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae).	Uridine monophosphate synthetase.	0.944
ENSNMLP00000014510	ENSNMLP00000003100	Uridine-cytidine kinase 1-like 1b.	Wu:fi36a10.	0.942
ENSNMLP00000014510	ENSNMLP00000010135	Uridine-cytidine kinase 1-like 1b.	annotation not available	0.942

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.962

expected number of edges:

10

PPI enrichment p-value:

1.55e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031204

Post-translational protein targeting to membrane, translocation

4 of 6

3.28

4.69

2.97e-09

GO:0045047

Protein targeting to ER

5 of 28

2.7

4.55

2.49e-09

GO:0006612

Protein targeting to membrane

5 of 51

2.44

4.16

6.70e-09

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

4 of 17

2.82

3.98

4.00e-08

GO:0006616

SRP-dependent cotranslational protein targeting to membrane, translocation

3 of 5

3.23

3.36

8.22e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043022

Ribosome binding

4 of 61

2.27

2.52

1.25e-05

GO:0008320

Protein transmembrane transporter activity

2 of 13

2.64

1.13

0.0088

GO:0019838

Growth factor binding

2 of 18

2.5

1.12

0.0088

GO:0042562

Hormone binding

2 of 26

2.34

1.04

0.0119

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140534

Endoplasmic reticulum protein-containing complex

7 of 74

2.43

6.44

3.60e-14

GO:0071256

Translocon complex

4 of 4

3.45

5.6

7.00e-11

GO:0005789

Endoplasmic reticulum membrane

11 of 581

1.73

4.5

1.14e-16

GO:0005784

Sec61 translocon complex

3 of 3

3.45

4.0

5.84e-08

GO:0008250

Oligosaccharyltransferase complex

3 of 10

2.93

3.38

6.25e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31634

Oligosaccharyltransferase complex, and Post-translational protein targeting to membrane, translocation

10 of 24

3.07

13.33

2.63e-26

CL:31636

Oligosaccharyltransferase complex, and Translocon-associated

8 of 18

3.1

10.68

7.22e-21

CL:31661

Mixed, incl. Sec61beta family, and Translocon-associated

5 of 5

3.45

6.95

2.28e-13

CL:31638

Oligosaccharyltransferase complex

3 of 11

2.89

5.12e-06

CL:31641

Oligosaccharyltransferase complex

2 of 5

3.05

1.68

0.00093

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04141

Protein processing in endoplasmic reticulum

10 of 303

1.97

5.9

1.62e-17

map03060

Protein export

4 of 39

2.46

3.66

8.41e-08

map04145

Phagosome

4 of 151

1.87

2.29

1.03e-05

map00510

N-Glycan biosynthesis

2 of 71

1.9

0.99

0.0120

map00513

Various types of N-glycan biosynthesis

2 of 80

1.85

0.98

0.0121

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

6 of 115

2.17

4.09

1.80e-09

MAP-9609523

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

3 of 17

2.7

2.59

1.62e-05

MAP-72766

Translation

6 of 322

1.72

2.56

3.76e-07

MAP-9609507

Protein localization

3 of 210

1.61

0.87

0.0163

MAP-392499

Metabolism of proteins

6 of 2399

0.85

0.54

0.0181

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071256

Translocon complex

5 of 6

3.37

6.9

2.69e-13

GOCC:0005789

Endoplasmic reticulum membrane

9 of 199

2.11

6.09

7.43e-16

GOCC:0005784

Sec61 translocon complex

4 of 5

3.35

5.38

1.69e-10

GOCC:0005783

Endoplasmic reticulum

10 of 354

1.9

5.24

5.63e-16

GOCC:0098796

Membrane protein complex

8 of 516

1.64

3.15

1.69e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0256

Endoplasmic reticulum

4 of 61

2.27

2.93

1.65e-06

KW-0811

Translocation

2 of 13

2.64

1.72

0.00069

KW-1133

Transmembrane helix

10 of 6441

0.64

0.55

0.00019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03911

Sec61beta family

2 of 2

3.45

1.62

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030671

Protein transport Sec61-beta/Sbh

2 of 2

3.45

1.37

0.0035

IPR016482

Protein transport protein SecG/Sec61-beta/Sbh

2 of 2

3.45

1.37

0.0035

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