ENSNMLP00000019727 protein (Neogobius melanostomus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSNMLP00000019727

Connexin 31.7. (257 aa)

Predicted Functional Partners:

ENSNMLP00000005313

0.890

ENSNMLP00000023868

0.883

ENSNMLP00000019969

0.849

ENSNMLP00000038203

0.839

ENSNMLP00000038198

0.838

ENSNMLP00000038201

0.836

ENSNMLP00000030633

0.835

ENSNMLP00000027840

0.824

ENSNMLP00000039170

0.824

ENSNMLP00000000610

0.819

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000000610	ENSNMLP00000005313	annotation not available	Connexin 43.	0.880
ENSNMLP00000000610	ENSNMLP00000019727	annotation not available	Connexin 31.7.	0.819
ENSNMLP00000000610	ENSNMLP00000019969	annotation not available	annotation not available	0.860
ENSNMLP00000000610	ENSNMLP00000023868	annotation not available	annotation not available	0.861
ENSNMLP00000000610	ENSNMLP00000027840	annotation not available	Gap junction protein, alpha 5a.	0.808
ENSNMLP00000000610	ENSNMLP00000030633	annotation not available	Connexin 47.1.	0.863
ENSNMLP00000000610	ENSNMLP00000038198	annotation not available	Connexin 34.5.	0.871
ENSNMLP00000000610	ENSNMLP00000038201	annotation not available	Connexin 32.3.	0.867
ENSNMLP00000000610	ENSNMLP00000038203	annotation not available	Connexin 28.9.	0.869
ENSNMLP00000000610	ENSNMLP00000039170	annotation not available	annotation not available	0.808
ENSNMLP00000005313	ENSNMLP00000000610	Connexin 43.	annotation not available	0.880
ENSNMLP00000005313	ENSNMLP00000019727	Connexin 43.	Connexin 31.7.	0.890
ENSNMLP00000005313	ENSNMLP00000019969	Connexin 43.	annotation not available	0.889
ENSNMLP00000005313	ENSNMLP00000023868	Connexin 43.	annotation not available	0.932
ENSNMLP00000005313	ENSNMLP00000027840	Connexin 43.	Gap junction protein, alpha 5a.	0.912
ENSNMLP00000005313	ENSNMLP00000030633	Connexin 43.	Connexin 47.1.	0.936
ENSNMLP00000005313	ENSNMLP00000038198	Connexin 43.	Connexin 34.5.	0.852
ENSNMLP00000005313	ENSNMLP00000038201	Connexin 43.	Connexin 32.3.	0.848
ENSNMLP00000005313	ENSNMLP00000038203	Connexin 43.	Connexin 28.9.	0.850
ENSNMLP00000005313	ENSNMLP00000039170	Connexin 43.	annotation not available	0.911

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.895

expected number of edges:

11

PPI enrichment p-value:

1.9e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 100

1.34

2.22

1.96e-10

GO:0009059

Macromolecule biosynthetic process

11 of 164

1.17

1.72

1.96e-10

GO:0010467

Gene expression

11 of 187

1.11

1.57

1.96e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 244

1.0

1.26

1.51e-09

GO:0044238

Primary metabolic process

11 of 736

0.52

0.45

0.00011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 55

1.6

3.41

7.00e-13

GO:0019843

rRNA binding

8 of 41

1.64

3.03

5.68e-10

GO:0003723

RNA binding

9 of 99

1.3

1.97

4.42e-09

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.34

1.08

0.0103

GO:0000049

tRNA binding

3 of 24

1.44

0.83

0.0156

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 57

1.59

3.45

1.16e-13

GO:0044391

Ribosomal subunit

4 of 14

1.8

2.22

9.87e-06

GO:0015934

Large ribosomal subunit

3 of 8

1.92

1.89

0.00012

GO:0032991

Protein-containing complex

5 of 143

0.89

0.69

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27330141

(2016) Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity.

7 of 26

1.78

2.96

3.35e-08

PMID:28977619

(2017) The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression.

8 of 51

1.54

2.45

3.35e-08

PMID:22043294

(2011) Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

4 of 8

2.04

1.98

0.00011

PMID:20019804

(2009) Transcriptome and proteome exploration to model translation efficiency and protein stability in Lactococcus lactis.

6 of 65

1.31

1.32

0.00015

PMID:30779773

(2019) Multiplexing polysome profiling experiments to study translation in Escherichia coli.

3 of 7

1.98

1.24

0.0040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:95

rRNA-binding

8 of 31

1.76

3.73

1.37e-11

CL:86

Ribosome, and Translational elongation

11 of 69

1.55

3.38

1.30e-14

CL:89

Ribosome

10 of 59

1.57

3.36

2.01e-13

CL:91

Ribosome

9 of 50

1.6

3.28

4.05e-12

CL:147

Large ribosomal subunit rRNA binding, and Translation regulation

4 of 5

2.25

3.03

9.25e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

llm03010

Ribosome

10 of 55

1.6

3.53

9.24e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015934

Large ribosomal subunit

5 of 10

2.04

3.23

1.01e-07

GOCC:0005840

Ribosome

8 of 45

1.59

2.87

9.60e-10

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 6

2.04

1.94

0.00013

GOCC:0043229

Intracellular organelle

10 of 224

0.99

1.19

5.88e-08

GOCC:0032991

Protein-containing complex

6 of 331

0.6

0.38

0.0297

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 56

1.6

3.45

2.01e-13

KW-0699

rRNA-binding

8 of 39

1.66

3.24

9.68e-11

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