ENSNMLP00000019809 protein (Neogobius melanostomus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSNMLP00000019809

Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba. (748 aa)

Predicted Functional Partners:

ENSNMLP00000018317

0.755

ENSNMLP00000033544

0.755

ENSNMLP00000039562

0.755

ENSNMLP00000005603

0.753

ENSNMLP00000015226

0.610

PLXND1

0.610

ENSNMLP00000023007

0.610

ENSNMLP00000030186

0.610

ENSNMLP00000033620

0.610

ENSNMLP00000035114

0.610

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSNMLP00000005603	ENSNMLP00000015226	ENSNMLP00000005603	ENSNMLP00000015226	Neuropilin 1a.	Plexin A2.	0.871
ENSNMLP00000005603	ENSNMLP00000018317	ENSNMLP00000005603	ENSNMLP00000018317	Neuropilin 1a.	MET proto-oncogene, receptor tyrosine kinase.	0.684
ENSNMLP00000005603	ENSNMLP00000019809	ENSNMLP00000005603	ENSNMLP00000019809	Neuropilin 1a.	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba.	0.753
ENSNMLP00000005603	ENSNMLP00000023007	ENSNMLP00000005603	ENSNMLP00000023007	Neuropilin 1a.	Plexin b2b.	0.849
ENSNMLP00000005603	ENSNMLP00000030186	ENSNMLP00000005603	ENSNMLP00000030186	Neuropilin 1a.	Plexin b2a.	0.849
ENSNMLP00000005603	ENSNMLP00000033544	ENSNMLP00000005603	ENSNMLP00000033544	Neuropilin 1a.	Macrophage stimulating 1 receptor a.	0.684
ENSNMLP00000005603	ENSNMLP00000033620	ENSNMLP00000005603	ENSNMLP00000033620	Neuropilin 1a.	annotation not available	0.871
ENSNMLP00000005603	ENSNMLP00000035114	ENSNMLP00000005603	ENSNMLP00000035114	Neuropilin 1a.	annotation not available	0.871
ENSNMLP00000005603	ENSNMLP00000039562	ENSNMLP00000005603	ENSNMLP00000039562	Neuropilin 1a.	annotation not available	0.684
ENSNMLP00000005603	PLXND1	ENSNMLP00000005603	ENSNMLP00000022918	Neuropilin 1a.	Plexin D1.	0.871
ENSNMLP00000015226	ENSNMLP00000005603	ENSNMLP00000015226	ENSNMLP00000005603	Plexin A2.	Neuropilin 1a.	0.871
ENSNMLP00000015226	ENSNMLP00000018317	ENSNMLP00000015226	ENSNMLP00000018317	Plexin A2.	MET proto-oncogene, receptor tyrosine kinase.	0.589
ENSNMLP00000015226	ENSNMLP00000019809	ENSNMLP00000015226	ENSNMLP00000019809	Plexin A2.	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba.	0.610
ENSNMLP00000015226	ENSNMLP00000033544	ENSNMLP00000015226	ENSNMLP00000033544	Plexin A2.	Macrophage stimulating 1 receptor a.	0.589
ENSNMLP00000015226	ENSNMLP00000039562	ENSNMLP00000015226	ENSNMLP00000039562	Plexin A2.	annotation not available	0.589
ENSNMLP00000018317	ENSNMLP00000005603	ENSNMLP00000018317	ENSNMLP00000005603	MET proto-oncogene, receptor tyrosine kinase.	Neuropilin 1a.	0.684
ENSNMLP00000018317	ENSNMLP00000015226	ENSNMLP00000018317	ENSNMLP00000015226	MET proto-oncogene, receptor tyrosine kinase.	Plexin A2.	0.589
ENSNMLP00000018317	ENSNMLP00000019809	ENSNMLP00000018317	ENSNMLP00000019809	MET proto-oncogene, receptor tyrosine kinase.	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba.	0.755
ENSNMLP00000018317	ENSNMLP00000023007	ENSNMLP00000018317	ENSNMLP00000023007	MET proto-oncogene, receptor tyrosine kinase.	Plexin b2b.	0.756
ENSNMLP00000018317	ENSNMLP00000030186	ENSNMLP00000018317	ENSNMLP00000030186	MET proto-oncogene, receptor tyrosine kinase.	Plexin b2a.	0.756

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

13

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

7 of 14

2.2

4.77

4.05e-11

GO:0000162

Tryptophan biosynthetic process

4 of 4

2.5

3.23

7.12e-07

GO:0046417

Chorismate metabolic process

3 of 9

2.02

1.85

0.00020

GO:0008652

Cellular amino acid biosynthetic process

7 of 99

1.35

1.81

7.12e-07

GO:0019438

Aromatic compound biosynthetic process

10 of 203

1.19

1.71

2.70e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016829

Lyase activity

6 of 121

1.2

1.08

0.00060

GO:0016835

Carbon-oxygen lyase activity

4 of 46

1.44

1.03

0.0042

GO:0004834

Tryptophan synthase activity

2 of 2

2.5

1.03

0.0133

GO:0004106

Chorismate mutase activity

2 of 2

2.5

1.03

0.0133

GO:0016836

Hydro-lyase activity

3 of 37

1.41

0.7

0.0319

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1270

0.4

0.28

0.0388

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30808357

(2019) Metabolic engineering of microorganisms for production of aromatic compounds.

4 of 8

2.2

2.52

1.05e-05

PMID:34584039

(2021) Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production.

2 of 2

2.5

1.07

0.0109

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1391

Aromatic amino acid biosynthesis, and Anthranilate synthase/para-aminobenzoate synthase like domain

10 of 15

2.32

7.99

3.90e-19

CL:1393

Tryptophan biosynthesis

5 of 6

2.42

4.23

4.38e-09

CL:1407

Chorismate metabolic process

3 of 7

2.13

1.88

0.00022

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pha00400

Phenylalanine, tyrosine and tryptophan biosynthesis

8 of 18

2.15

5.67

5.08e-14

pha01230

Biosynthesis of amino acids

8 of 113

1.35

2.04

1.36e-08

pha00790

Folate biosynthesis

3 of 24

1.6

1.25

0.0018

pha01110

Biosynthesis of secondary metabolites

8 of 287

0.95

0.97

1.13e-05

pha01100

Metabolic pathways

8 of 632

0.6

0.46

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

7 of 12

2.27

5.34

3.03e-12

KW-0822

Tryptophan biosynthesis

5 of 5

2.5

4.45

2.07e-09

KW-0456

Lyase

9 of 133

1.33

2.1

1.40e-09

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04715

Anthranilate synthase component I, N terminal region

2 of 2

2.5

0.84

0.0299

PF00425

Chorismate binding enzyme

2 of 2

2.5

0.84

0.0299

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00830

Chorismate mutase type II

2 of 2

2.5

1.18

0.0068

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Cooccurrence

Experiments

Neighborhood

Databases

Fusion

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About