ENSNMLP00000019856 protein (Neogobius melanostomus)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Coexpression

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[Homology]

Score

ENSNMLP00000019856

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (154 aa)

Predicted Functional Partners:

ENSNMLP00000005217

0.999

ENSNMLP00000012095

0.999

ENSNMLP00000017362

0.999

ENSNMLP00000021513

0.999

ENSNMLP00000033281

0.999

ENSNMLP00000040820

0.999

ENSNMLP00000008245

0.998

TADA1

0.998

ENSNMLP00000032351

0.998

ENSNMLP00000037813

0.998

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSNMLP00000005217	ENSNMLP00000008245	ENSNMLP00000005217	ENSNMLP00000008245	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	SPT20 homolog, SAGA complex component.	0.976
ENSNMLP00000005217	ENSNMLP00000012095	ENSNMLP00000005217	ENSNMLP00000012095	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.999
ENSNMLP00000005217	ENSNMLP00000017362	ENSNMLP00000005217	ENSNMLP00000017362	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	annotation not available	0.999
ENSNMLP00000005217	ENSNMLP00000019856	ENSNMLP00000005217	ENSNMLP00000019856	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.999
ENSNMLP00000005217	ENSNMLP00000021513	ENSNMLP00000005217	ENSNMLP00000021513	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor.	0.999
ENSNMLP00000005217	ENSNMLP00000032351	ENSNMLP00000005217	ENSNMLP00000032351	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.999
ENSNMLP00000005217	ENSNMLP00000033281	ENSNMLP00000005217	ENSNMLP00000033281	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.999
ENSNMLP00000005217	ENSNMLP00000037813	ENSNMLP00000005217	ENSNMLP00000037813	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	SAGA complex associated factor 29.	0.994
ENSNMLP00000005217	ENSNMLP00000040820	ENSNMLP00000005217	ENSNMLP00000040820	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.999
ENSNMLP00000005217	TADA1	ENSNMLP00000005217	ENSNMLP00000024929	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Transcriptional adaptor 1.	0.995
ENSNMLP00000008245	ENSNMLP00000005217	ENSNMLP00000008245	ENSNMLP00000005217	SPT20 homolog, SAGA complex component.	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.976
ENSNMLP00000008245	ENSNMLP00000012095	ENSNMLP00000008245	ENSNMLP00000012095	SPT20 homolog, SAGA complex component.	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.894
ENSNMLP00000008245	ENSNMLP00000019856	ENSNMLP00000008245	ENSNMLP00000019856	SPT20 homolog, SAGA complex component.	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.998
ENSNMLP00000008245	ENSNMLP00000021513	ENSNMLP00000008245	ENSNMLP00000021513	SPT20 homolog, SAGA complex component.	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor.	0.994
ENSNMLP00000008245	ENSNMLP00000033281	ENSNMLP00000008245	ENSNMLP00000033281	SPT20 homolog, SAGA complex component.	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.996
ENSNMLP00000008245	ENSNMLP00000037813	ENSNMLP00000008245	ENSNMLP00000037813	SPT20 homolog, SAGA complex component.	SAGA complex associated factor 29.	0.998
ENSNMLP00000008245	TADA1	ENSNMLP00000008245	ENSNMLP00000024929	SPT20 homolog, SAGA complex component.	Transcriptional adaptor 1.	0.992
ENSNMLP00000012095	ENSNMLP00000005217	ENSNMLP00000012095	ENSNMLP00000005217	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.999
ENSNMLP00000012095	ENSNMLP00000008245	ENSNMLP00000012095	ENSNMLP00000008245	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	SPT20 homolog, SAGA complex component.	0.894
ENSNMLP00000012095	ENSNMLP00000017362	ENSNMLP00000012095	ENSNMLP00000017362	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	annotation not available	0.999

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.927

expected number of edges:

11

PPI enrichment p-value:

1.65e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006032

Chitin catabolic process

3 of 46

2.17

1.91

0.0013

GO:0005975

Carbohydrate metabolic process

5 of 391

1.47

1.67

0.00017

GO:0000272

Polysaccharide catabolic process

3 of 132

1.72

1.37

0.0051

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004553

Hydrolase activity, hydrolyzing O-glycosyl compounds

5 of 189

1.78

2.82

2.09e-06

GO:0004568

Chitinase activity

3 of 38

2.26

2.41

0.00022

GO:0008061

Chitin binding

3 of 49

2.15

2.24

0.00034

GO:0102148

N-acetyl-beta-D-galactosaminidase activity

2 of 8

2.76

1.89

0.0022

GO:0004563

beta-N-acetylhexosaminidase activity

2 of 8

2.76

1.89

0.0022

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005576

Extracellular region

5 of 432

1.42

1.7

6.50e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:21184821

(2011) Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical application of the butanol extract of Cordyceps bassiana in NCNga mice.

2 of 7

2.82

2.05

0.0013

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16527

Glycosyl hydrolases family 18, and beta-Lactam resistance

5 of 15

2.88

7.31

1.73e-11

CL:16544

Glycosyl hydrolases family 18

3 of 6

3.06

4.43

5.55e-07

CL:16530

beta-Lactam resistance, and Beta-acetyl hexosaminidase like

2 of 5

2.96

2.36

0.00049

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00520

Amino sugar and nucleotide sugar metabolism

5 of 177

1.81

3.25

1.49e-07

map00604

Glycosphingolipid biosynthesis - ganglio series

2 of 13

2.55

2.04

0.0012

map00603

Glycosphingolipid biosynthesis - globo and isoglobo series

2 of 19

2.38

1.92

0.0016

map00511

Other glycan degradation

2 of 22

2.32

1.9

0.0016

map00531

Glycosaminoglycan degradation

2 of 29

2.2

1.78

0.0022

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2160916

Hyaluronan uptake and degradation

2 of 9

2.71

1.56

0.0065

MAP-2024101

CS/DS degradation

2 of 8

2.76

1.56

0.0065

MAP-1793185

Chondroitin sulfate/dermatan sulfate metabolism

2 of 8

2.76

1.56

0.0065

MAP-2022857

Keratan sulfate degradation

2 of 13

2.55

1.54

0.0065

MAP-1638074

Keratan sulfate/keratin metabolism

2 of 13

2.55

1.54

0.0065

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009277

Fungal-type cell wall

3 of 48

2.16

2.03

0.00081

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0326

Glycosidase

4 of 72

2.1

3.37

2.15e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00704

Glycosyl hydrolases family 18

3 of 13

2.72

3.23

2.32e-05

PF14845

Beta-acetyl hexosaminidase like

2 of 3

3.18

2.23

0.00079

PF00728

Glycosyl hydrolase family 20, catalytic domain

2 of 9

2.71

1.8

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017853

Glycoside hydrolase superfamily

5 of 117

1.99

3.53

3.60e-07

IPR001223

Glycoside hydrolase family 18, catalytic domain

3 of 29

2.37

2.4

0.00028

IPR029019

Beta-hexosaminidase, eukaryotic type, N-terminal

2 of 3

3.18

2.05

0.0014

IPR025705

Beta-hexosaminidase

2 of 9

2.71

1.58

0.0060

IPR015883

Glycoside hydrolase family 20, catalytic domain

2 of 9

2.71

1.58

0.0060

(more ...)

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