ENSNMLP00000022030 protein (Neogobius melanostomus)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Experiments

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Score

ENSNMLP00000022030

Mitogen-activated protein kinase 3. (394 aa)

Predicted Functional Partners:

ENSNMLP00000011957

0.959

ENSNMLP00000000857

0.950

ENSNMLP00000029997

0.950

ENSNMLP00000040027

0.950

MAP2K6

0.948

ENSNMLP00000019146

0.947

ENSNMLP00000023861

0.937

ENSNMLP00000043284

0.937

ENSNMLP00000013624

0.931

ENSNMLP00000034927

0.929

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSNMLP00000000857	ENSNMLP00000022030	ENSNMLP00000000857	ENSNMLP00000022030	Dual specificity phosphatase 6.	Mitogen-activated protein kinase 3.	0.950
ENSNMLP00000011957	ENSNMLP00000022030	ENSNMLP00000011957	ENSNMLP00000022030	Mitogen-activated protein kinase kinase 2a.	Mitogen-activated protein kinase 3.	0.959
ENSNMLP00000013624	ENSNMLP00000022030	ENSNMLP00000013624	ENSNMLP00000022030	cAMP responsive element binding protein 5b.	Mitogen-activated protein kinase 3.	0.931
ENSNMLP00000013624	ENSNMLP00000034927	ENSNMLP00000013624	ENSNMLP00000034927	cAMP responsive element binding protein 5b.	Ribosomal protein S6 kinase a, polypeptide 1.	0.556
ENSNMLP00000019146	ENSNMLP00000022030	ENSNMLP00000019146	ENSNMLP00000022030	ETS transcription factor ELK1.	Mitogen-activated protein kinase 3.	0.947
ENSNMLP00000022030	ENSNMLP00000000857	ENSNMLP00000022030	ENSNMLP00000000857	Mitogen-activated protein kinase 3.	Dual specificity phosphatase 6.	0.950
ENSNMLP00000022030	ENSNMLP00000011957	ENSNMLP00000022030	ENSNMLP00000011957	Mitogen-activated protein kinase 3.	Mitogen-activated protein kinase kinase 2a.	0.959
ENSNMLP00000022030	ENSNMLP00000013624	ENSNMLP00000022030	ENSNMLP00000013624	Mitogen-activated protein kinase 3.	cAMP responsive element binding protein 5b.	0.931
ENSNMLP00000022030	ENSNMLP00000019146	ENSNMLP00000022030	ENSNMLP00000019146	Mitogen-activated protein kinase 3.	ETS transcription factor ELK1.	0.947
ENSNMLP00000022030	ENSNMLP00000023861	ENSNMLP00000022030	ENSNMLP00000023861	Mitogen-activated protein kinase 3.	MAPK interacting serine/threonine kinase 1.	0.937
ENSNMLP00000022030	ENSNMLP00000029997	ENSNMLP00000022030	ENSNMLP00000029997	Mitogen-activated protein kinase 3.	Dual specificity phosphatase 7.	0.950
ENSNMLP00000022030	ENSNMLP00000034927	ENSNMLP00000022030	ENSNMLP00000034927	Mitogen-activated protein kinase 3.	Ribosomal protein S6 kinase a, polypeptide 1.	0.929
ENSNMLP00000022030	ENSNMLP00000040027	ENSNMLP00000022030	ENSNMLP00000040027	Mitogen-activated protein kinase 3.	annotation not available	0.950
ENSNMLP00000022030	ENSNMLP00000043284	ENSNMLP00000022030	ENSNMLP00000043284	Mitogen-activated protein kinase 3.	MAPK interacting serine/threonine kinase 2b.	0.937
ENSNMLP00000022030	MAP2K6	ENSNMLP00000022030	ENSNMLP00000015970	Mitogen-activated protein kinase 3.	Mitogen-activated protein kinase kinase 6.	0.948
ENSNMLP00000023861	ENSNMLP00000022030	ENSNMLP00000023861	ENSNMLP00000022030	MAPK interacting serine/threonine kinase 1.	Mitogen-activated protein kinase 3.	0.937
ENSNMLP00000023861	ENSNMLP00000043284	ENSNMLP00000023861	ENSNMLP00000043284	MAPK interacting serine/threonine kinase 1.	MAPK interacting serine/threonine kinase 2b.	0.839
ENSNMLP00000029997	ENSNMLP00000022030	ENSNMLP00000029997	ENSNMLP00000022030	Dual specificity phosphatase 7.	Mitogen-activated protein kinase 3.	0.950
ENSNMLP00000034927	ENSNMLP00000013624	ENSNMLP00000034927	ENSNMLP00000013624	Ribosomal protein S6 kinase a, polypeptide 1.	cAMP responsive element binding protein 5b.	0.556
ENSNMLP00000034927	ENSNMLP00000022030	ENSNMLP00000034927	ENSNMLP00000022030	Ribosomal protein S6 kinase a, polypeptide 1.	Mitogen-activated protein kinase 3.	0.929

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.787

expected number of edges:

14

PPI enrichment p-value:

0.0197

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001963

Synaptic transmission, dopaminergic

3 of 14

2.59

1.81

0.00046

GO:0042417

Dopamine metabolic process

3 of 17

2.51

1.78

0.00051

GO:0098810

Neurotransmitter reuptake

3 of 18

2.48

1.77

0.00051

GO:0015844

Monoamine transport

3 of 18

2.48

1.77

0.00051

GO:0007212

Dopamine receptor signaling pathway

3 of 21

2.42

1.76

0.00051

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035240

Dopamine binding

3 of 6

2.96

2.48

3.07e-05

GO:0001591

Dopamine neurotransmitter receptor activity, coupled via Gi/Go

2 of 3

3.08

1.42

0.0027

GO:0015378

Sodium:chloride symporter activity

2 of 9

2.61

1.12

0.0090

GO:0008504

Monoamine transmembrane transporter activity

2 of 9

2.61

1.12

0.0090

GO:0005326

Neurotransmitter transmembrane transporter activity

2 of 14

2.42

1.04

0.0122

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

3 of 29

2.28

1.6

0.00094

GO:0036477

Somatodendritic compartment

5 of 589

1.19

0.87

0.0046

GO:0030425

Dendrite

4 of 436

1.22

0.8

0.0104

GO:0098797

Plasma membrane protein complex

4 of 456

1.2

0.79

0.0104

GO:0030424

Axon

4 of 477

1.18

0.78

0.0105

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:26528222

(2015) Genetic influences on insight problem solving: the role of catechol-O-methyltransferase (COMT) gene polymorphisms.

3 of 5

3.04

2.56

2.23e-05

PMID:34072960

(2021) Understanding Emotions: Origins and Roles of the Amygdala.

3 of 12

2.66

2.19

9.02e-05

PMID:29579395

(2018) Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.

3 of 16

2.53

2.09

0.00013

PMID:33343403

(2020) The Autism Palette: Combinations of Impairments Explain the Heterogeneity in ASD.

2 of 6

2.78

1.22

0.0062

PMID:31616587

(2019) The dopamine receptor D5 gene shows signs of independent erosion in toothed and baleen whales.

2 of 6

2.78

1.22

0.0062

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:35990

Opioid Signalling, and Amine ligand-binding receptors

9 of 86

2.28

6.91

1.90e-16

CL:35991

Opioid Signalling, and Amine ligand-binding receptors

7 of 80

2.2

5.05

7.85e-12

CL:36005

Mixed, incl. Norepinephrine binding, and Mu-type opioid receptor binding

3 of 5

3.04

2.92

4.87e-06

CL:35999

G alpha (z) signalling events, and G-protein beta/gamma-subunit complex binding

4 of 35

2.32

2.81

3.40e-06

CL:36137

Dopamine receptors, and Response to gravity

3 of 7

2.89

2.79

7.83e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lav04726

Serotonergic synapse

4 of 94

1.89

2.01

5.73e-05

lav04728

Dopaminergic synapse

4 of 101

1.86

1.98

5.73e-05

lav04713

Circadian entrainment

3 of 75

1.86

1.48

0.0010

lav05032

Morphine addiction

3 of 79

1.84

1.47

0.0010

lav04727

GABAergic synapse

3 of 77

1.85

1.47

0.0010

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-112311

Neurotransmitter clearance

3 of 9

2.78

2.53

2.30e-05

MAP-112315

Transmission across Chemical Synapses

6 of 261

1.62

2.12

3.93e-06

MAP-451326

Activation of kainate receptors upon glutamate binding

3 of 32

2.23

1.82

0.00034

MAP-4086398

Ca2+ pathway

3 of 41

2.12

1.68

0.00055

MAP-112316

Neuronal System

6 of 412

1.42

1.65

2.30e-05

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0003954

Dopaminergic system

3 of 4

3.14

2.87

6.19e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

3 of 16

2.53

1.99

0.00020

GOCC:0071944

Cell periphery

9 of 4127

0.6

0.44

0.0051

GOCC:0005886

Plasma membrane

8 of 3874

0.58

0.36

0.0304

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0769

Symport

2 of 27

2.13

0.76

0.0383

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016346

Guanine nucleotide-binding protein, beta subunit

2 of 4

2.96

0.86

0.0279

IPR001632

G-protein, beta subunit

2 of 6

2.78

0.86

0.0279

IPR000929

Dopamine receptor family

2 of 5

2.86

0.86

0.0279

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