ENSNMLP00000023885 protein (Neogobius melanostomus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSNMLP00000023885

annotation not available (355 aa)

Predicted Functional Partners:

ENSNMLP00000034002

0.841

ENSNMLP00000025171

0.837

ENSNMLP00000042996

0.806

ENSNMLP00000010562

0.796

ENSNMLP00000013779

0.796

ENSNMLP00000018040

0.775

ENSNMLP00000036137

0.758

ENSNMLP00000039709

0.758

ENSNMLP00000012348

0.750

ENSNMLP00000021616

0.747

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000010562	ENSNMLP00000013779	annotation not available	Translocase of outer mitochondrial membrane 20.	0.751
ENSNMLP00000010562	ENSNMLP00000023885	annotation not available	annotation not available	0.796
ENSNMLP00000010562	ENSNMLP00000025171	annotation not available	annotation not available	0.796
ENSNMLP00000010562	ENSNMLP00000039709	annotation not available	annotation not available	0.796
ENSNMLP00000012348	ENSNMLP00000023885	Si:dkey-28b4.7.	annotation not available	0.750
ENSNMLP00000012348	ENSNMLP00000025171	Si:dkey-28b4.7.	annotation not available	0.750
ENSNMLP00000012348	ENSNMLP00000036137	Si:dkey-28b4.7.	Polymerase (DNA directed), delta 1, catalytic subunit.	0.994
ENSNMLP00000012348	ENSNMLP00000039709	Si:dkey-28b4.7.	annotation not available	0.750
ENSNMLP00000012348	ENSNMLP00000042996	Si:dkey-28b4.7.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.994
ENSNMLP00000013779	ENSNMLP00000010562	Translocase of outer mitochondrial membrane 20.	annotation not available	0.751
ENSNMLP00000013779	ENSNMLP00000023885	Translocase of outer mitochondrial membrane 20.	annotation not available	0.796
ENSNMLP00000013779	ENSNMLP00000025171	Translocase of outer mitochondrial membrane 20.	annotation not available	0.796
ENSNMLP00000013779	ENSNMLP00000039709	Translocase of outer mitochondrial membrane 20.	annotation not available	0.796
ENSNMLP00000018040	ENSNMLP00000023885	annotation not available	annotation not available	0.775
ENSNMLP00000018040	ENSNMLP00000025171	annotation not available	annotation not available	0.775
ENSNMLP00000018040	ENSNMLP00000036137	annotation not available	Polymerase (DNA directed), delta 1, catalytic subunit.	0.994
ENSNMLP00000018040	ENSNMLP00000039709	annotation not available	annotation not available	0.775
ENSNMLP00000018040	ENSNMLP00000042996	annotation not available	Polymerase (DNA directed), delta 2, regulatory subunit.	0.422
ENSNMLP00000021616	ENSNMLP00000023885	Small nuclear ribonucleoprotein D2 polypeptide.	annotation not available	0.747
ENSNMLP00000021616	ENSNMLP00000025171	Small nuclear ribonucleoprotein D2 polypeptide.	annotation not available	0.747

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.838

expected number of edges:

12

PPI enrichment p-value:

1.72e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

10 of 148

1.8

4.55

6.70e-15

GO:0008380

RNA splicing

11 of 186

1.74

4.5

3.26e-16

GO:0006397

mRNA processing

11 of 221

1.67

4.06

1.03e-15

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003677

DNA binding

6 of 636

0.94

0.61

0.0149

GO:0003676

Nucleic acid binding

8 of 1224

0.78

0.55

0.0072

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000974

Prp19 complex

8 of 15

2.7

8.39

2.03e-17

GO:0005681

Spliceosomal complex

10 of 127

1.86

5.06

5.39e-16

GO:0071014

post-mRNA release spliceosomal complex

3 of 20

2.14

1.93

0.00017

GO:0005634

Nucleus

11 of 2103

0.69

0.65

4.28e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5935

mRNA Splicing, and U2-type spliceosomal complex

10 of 149

1.8

4.5

1.03e-14

CL:5936

mRNA Splicing

9 of 131

1.81

4.2

5.34e-13

CL:5940

mRNA Splicing

6 of 107

1.72

2.56

3.60e-07

CL:6057

Prp19 complex, and mRNA Splicing - Major Pathway

4 of 33

2.05

2.4

1.21e-05

CL:5944

mRNA Splicing

5 of 102

1.66

2.03

1.21e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

9 of 158

1.72

3.9

5.15e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72163

mRNA Splicing - Major Pathway

8 of 118

1.8

3.72

6.16e-11

MAP-72172

mRNA Splicing

8 of 129

1.76

3.61

6.16e-11

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

8 of 209

1.55

2.71

1.71e-09

MAP-8953854

Metabolism of RNA

8 of 565

1.12

1.3

2.98e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000974

Prp19 complex

7 of 13

2.7

7.15

1.02e-14

GOCC:0032991

Protein-containing complex

10 of 2145

0.64

0.52

0.00070

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00857

Isochorismatase family

5 of 13

2.55

4.37

3.67e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000868

Isochorismatase-like

5 of 12

2.59

4.24

7.63e-09

IPR036380

Isochorismatase-like superfamily

5 of 13

2.55

4.22

7.63e-09

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