ENSNMLP00000025736 protein (Neogobius melanostomus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSNMLP00000025736

annotation not available (115 aa)

Predicted Functional Partners:

CAPZA2

0.883

ENSNMLP00000035475

0.883

ENSNMLP00000032172

0.694

STK38

0.694

ENSNMLP00000004700

0.666

ENSNMLP00000033427

0.571

ENSNMLP00000038941

0.499

ENSNMLP00000035966

0.407

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAPZA2	ENSNMLP00000004700	ENSNMLP00000014953	ENSNMLP00000004700	Capping actin protein of muscle Z-line subunit alpha 2.	S100 calcium binding protein U.	0.435
CAPZA2	ENSNMLP00000025736	ENSNMLP00000014953	ENSNMLP00000025736	Capping actin protein of muscle Z-line subunit alpha 2.	annotation not available	0.883
ENSNMLP00000004700	CAPZA2	ENSNMLP00000004700	ENSNMLP00000014953	S100 calcium binding protein U.	Capping actin protein of muscle Z-line subunit alpha 2.	0.435
ENSNMLP00000004700	ENSNMLP00000025736	ENSNMLP00000004700	ENSNMLP00000025736	S100 calcium binding protein U.	annotation not available	0.666
ENSNMLP00000004700	ENSNMLP00000033427	ENSNMLP00000004700	ENSNMLP00000033427	S100 calcium binding protein U.	annotation not available	0.573
ENSNMLP00000004700	ENSNMLP00000035475	ENSNMLP00000004700	ENSNMLP00000035475	S100 calcium binding protein U.	Zgc:112496.	0.435
ENSNMLP00000004700	ENSNMLP00000038941	ENSNMLP00000004700	ENSNMLP00000038941	S100 calcium binding protein U.	annotation not available	0.499
ENSNMLP00000025736	CAPZA2	ENSNMLP00000025736	ENSNMLP00000014953	annotation not available	Capping actin protein of muscle Z-line subunit alpha 2.	0.883
ENSNMLP00000025736	ENSNMLP00000004700	ENSNMLP00000025736	ENSNMLP00000004700	annotation not available	S100 calcium binding protein U.	0.666
ENSNMLP00000025736	ENSNMLP00000032172	ENSNMLP00000025736	ENSNMLP00000032172	annotation not available	Serine/threonine kinase 38 like.	0.694
ENSNMLP00000025736	ENSNMLP00000033427	ENSNMLP00000025736	ENSNMLP00000033427	annotation not available	annotation not available	0.571
ENSNMLP00000025736	ENSNMLP00000035475	ENSNMLP00000025736	ENSNMLP00000035475	annotation not available	Zgc:112496.	0.883
ENSNMLP00000025736	ENSNMLP00000035966	ENSNMLP00000025736	ENSNMLP00000035966	annotation not available	Si:dkey-29p10.4.	0.407
ENSNMLP00000025736	ENSNMLP00000038941	ENSNMLP00000025736	ENSNMLP00000038941	annotation not available	annotation not available	0.499
ENSNMLP00000025736	STK38	ENSNMLP00000025736	ENSNMLP00000041328	annotation not available	Serine/threonine kinase 38.	0.694
ENSNMLP00000032172	ENSNMLP00000025736	ENSNMLP00000032172	ENSNMLP00000025736	Serine/threonine kinase 38 like.	annotation not available	0.694
ENSNMLP00000033427	ENSNMLP00000004700	ENSNMLP00000033427	ENSNMLP00000004700	annotation not available	S100 calcium binding protein U.	0.573
ENSNMLP00000033427	ENSNMLP00000025736	ENSNMLP00000033427	ENSNMLP00000025736	annotation not available	annotation not available	0.571
ENSNMLP00000035475	ENSNMLP00000004700	ENSNMLP00000035475	ENSNMLP00000004700	Zgc:112496.	S100 calcium binding protein U.	0.435
ENSNMLP00000035475	ENSNMLP00000025736	ENSNMLP00000035475	ENSNMLP00000025736	Zgc:112496.	annotation not available	0.883

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.911

expected number of edges:

11

PPI enrichment p-value:

2.24e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007035

Vacuolar acidification

4 of 11

2.23

2.14

7.25e-05

GO:0070072

Vacuolar proton-transporting V-type ATPase complex assembly

2 of 5

2.27

0.88

0.0243

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

4 of 15

2.1

2.0

0.00011

GO:0015075

Ion transmembrane transporter activity

5 of 184

1.1

0.79

0.0061

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016471

Vacuolar proton-transporting V-type ATPase complex

4 of 14

2.13

2.23

3.64e-05

GO:0000220

Vacuolar proton-transporting V-type ATPase, V0 domain

3 of 6

2.37

1.94

0.00022

GO:0000329

Fungal-type vacuole membrane

5 of 120

1.29

1.17

0.00057

GO:0098588

Bounding membrane of organelle

6 of 450

0.79

0.54

0.0104

GO:0031090

Organelle membrane

9 of 997

0.63

0.49

0.0018

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:26791325

(2016) Predicting chemotherapeutic drug combinations through gene network profiling.

5 of 27

1.94

2.06

5.26e-05

PMID:36422040

(2022) Subunit C of V-ATPase-VmaC Is Required for Hyphal Growth and Conidiation in A. fumigatus by Affecting Vacuolar Calcium Homeostasis and Cell Wall Integration.

4 of 15

2.1

1.75

0.00038

PMID:24708151

(2014) A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system.

4 of 18

2.02

1.68

0.00047

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2344

Vacuolar proton-transporting V-type ATPase complex

4 of 13

2.16

2.29

2.95e-05

CL:7052

Mixed, incl. Vacuolar proton-transporting V-type ATPase complex assembly, and Exopolyphosphatase activity

4 of 19

1.99

2.08

5.45e-05

CL:7055

Mixed, incl. Glycine transport, and Cactus-binding C-terminus of cactin protein

3 of 6

2.37

2.0

0.00017

CL:2348

Insulin receptor recycling

3 of 8

2.24

1.91

0.00022

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

spo04145

Phagosome

4 of 33

1.75

1.85

7.82e-05

spo00190

Oxidative phosphorylation

4 of 65

1.46

1.34

0.00049

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

SPO-917977

Transferrin endocytosis and recycling

4 of 13

2.16

2.38

1.85e-05

SPO-77387

Insulin receptor recycling

4 of 13

2.16

2.38

1.85e-05

SPO-1222556

ROS and RNS production in phagocytes

4 of 14

2.13

2.37

1.85e-05

SPO-9639288

Amino acids regulate mTORC1

4 of 20

1.97

2.27

1.85e-05

SPO-168249

Innate Immune System

5 of 191

1.09

0.89

0.0017

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016471

Vacuolar proton-transporting V-type ATPase complex

4 of 14

2.13

2.26

3.15e-05

GOCC:0000220

Vacuolar proton-transporting V-type ATPase, V0 domain

3 of 6

2.37

2.04

0.00014

GOCC:0005774

Vacuolar membrane

5 of 133

1.24

1.12

0.00060

GOCC:0031090

Organelle membrane

9 of 616

0.83

0.77

7.33e-05

GOCC:0098588

Bounding membrane of organelle

6 of 313

0.95

0.77

0.0016

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

4 of 33

1.75

1.68

0.00023

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