ENSNMLP00000031178 protein (Neogobius melanostomus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSNMLP00000031178

Nuclear receptor binding protein 2b. (496 aa)

Predicted Functional Partners:

ENSNMLP00000032621

0.699

ENSNMLP00000003547

0.660

ELOB

0.660

ENSNMLP00000000866

0.623

ENSNMLP00000003961

0.623

ENSNMLP00000003965

0.623

ENSNMLP00000026560

0.623

ENSNMLP00000026564

0.623

ENSNMLP00000030675

0.623

ENSNMLP00000030748

0.623

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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structured XML interaction data, according to the 'PSI-MI' data standard

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ELOB	ENSNMLP00000003547	ENSNMLP00000013174	ENSNMLP00000003547	Elongin B.	annotation not available	0.849
ELOB	ENSNMLP00000031178	ENSNMLP00000013174	ENSNMLP00000031178	Elongin B.	Nuclear receptor binding protein 2b.	0.660
ELOB	ENSNMLP00000032621	ENSNMLP00000013174	ENSNMLP00000032621	Elongin B.	Elongin C paralog a.	0.993
ENSNMLP00000000866	ENSNMLP00000026560	ENSNMLP00000000866	ENSNMLP00000026560	annotation not available	annotation not available	0.400
ENSNMLP00000000866	ENSNMLP00000030748	ENSNMLP00000000866	ENSNMLP00000030748	annotation not available	annotation not available	0.408
ENSNMLP00000000866	ENSNMLP00000031178	ENSNMLP00000000866	ENSNMLP00000031178	annotation not available	Nuclear receptor binding protein 2b.	0.623
ENSNMLP00000003547	ELOB	ENSNMLP00000003547	ENSNMLP00000013174	annotation not available	Elongin B.	0.849
ENSNMLP00000003547	ENSNMLP00000031178	ENSNMLP00000003547	ENSNMLP00000031178	annotation not available	Nuclear receptor binding protein 2b.	0.660
ENSNMLP00000003547	ENSNMLP00000032621	ENSNMLP00000003547	ENSNMLP00000032621	annotation not available	Elongin C paralog a.	0.993
ENSNMLP00000003961	ENSNMLP00000031178	ENSNMLP00000003961	ENSNMLP00000031178	annotation not available	Nuclear receptor binding protein 2b.	0.623
ENSNMLP00000003965	ENSNMLP00000031178	ENSNMLP00000003965	ENSNMLP00000031178	annotation not available	Nuclear receptor binding protein 2b.	0.623
ENSNMLP00000026560	ENSNMLP00000000866	ENSNMLP00000026560	ENSNMLP00000000866	annotation not available	annotation not available	0.400
ENSNMLP00000026560	ENSNMLP00000026564	ENSNMLP00000026560	ENSNMLP00000026564	annotation not available	annotation not available	0.895
ENSNMLP00000026560	ENSNMLP00000031178	ENSNMLP00000026560	ENSNMLP00000031178	annotation not available	Nuclear receptor binding protein 2b.	0.623
ENSNMLP00000026564	ENSNMLP00000026560	ENSNMLP00000026564	ENSNMLP00000026560	annotation not available	annotation not available	0.895
ENSNMLP00000026564	ENSNMLP00000030748	ENSNMLP00000026564	ENSNMLP00000030748	annotation not available	annotation not available	0.801
ENSNMLP00000026564	ENSNMLP00000031178	ENSNMLP00000026564	ENSNMLP00000031178	annotation not available	Nuclear receptor binding protein 2b.	0.623
ENSNMLP00000030675	ENSNMLP00000031178	ENSNMLP00000030675	ENSNMLP00000031178	Si:ch211-220e11.3.	Nuclear receptor binding protein 2b.	0.623
ENSNMLP00000030748	ENSNMLP00000000866	ENSNMLP00000030748	ENSNMLP00000000866	annotation not available	annotation not available	0.408
ENSNMLP00000030748	ENSNMLP00000026564	ENSNMLP00000030748	ENSNMLP00000026564	annotation not available	annotation not available	0.801

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.815

expected number of edges:

11

PPI enrichment p-value:

4.94e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006289

Nucleotide-excision repair

5 of 35

2.34

3.36

2.46e-07

GO:0006354

DNA-templated transcription, elongation

4 of 26

2.37

2.56

1.23e-05

GO:0006283

Transcription-coupled nucleotide-excision repair

3 of 7

2.82

2.25

7.60e-05

GO:0006368

Transcription elongation from RNA polymerase II promoter

3 of 24

2.28

1.74

0.00050

GO:0009411

Response to UV

4 of 84

1.86

1.67

0.00034

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000993

RNA polymerase II complex binding

3 of 32

2.16

1.29

0.0036

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008023

Transcription elongation factor complex

4 of 44

2.14

2.31

2.55e-05

GO:0016593

Cdc73/Paf1 complex

2 of 7

2.64

1.49

0.0019

GO:0000109

Nucleotide-excision repair complex

2 of 6

2.71

1.49

0.0019

GO:0031464

Cul4A-RING E3 ubiquitin ligase complex

2 of 10

2.48

1.36

0.0031

GO:0016591

RNA polymerase II, holoenzyme

3 of 69

1.82

1.34

0.0019

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27507608

(2017) Cockayne syndrome: Clinical features, model systems and pathways.

4 of 8

2.88

2.87

5.56e-06

PMID:30753618

(2019) Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein.

3 of 8

2.76

1.52

0.0017

PMID:32649862

(2020) A Genetic Map of the Response to DNA Damage in Human Cells.

4 of 50

2.09

1.44

0.0017

PMID:33007515

(2020) Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair.

3 of 17

2.43

1.18

0.0067

PMID:36077479

(2022) Genome of Laudakia sacra Provides New Insights into High-Altitude Adaptation of Ectotherms.

3 of 34

2.13

0.78

0.0362

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7860

Nucleotide-excision repair factor 1 complex, and Double-strand break repair via classical nonhomologous end joining

3 of 5

2.96

2.39

4.45e-05

CL:9183

Mixed, incl. BAT3 complex binding, and Zinc finger, SIAH-type

2 of 5

2.79

1.1

0.0104

CL:7139

RNA Polymerase II Pre-transcription Events, and Mediator complex

3 of 121

1.58

0.67

0.0448

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gga03420

Nucleotide excision repair

5 of 35

2.34

4.14

4.50e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

GGA-6781823

Formation of TC-NER Pre-Incision Complex

3 of 38

2.08

1.28

0.0035

GGA-6782210

Gap-filling DNA repair synthesis and ligation in TC-NER

3 of 43

2.03

1.27

0.0035

GGA-6782135

Dual incision in TC-NER

3 of 46

2.0

1.27

0.0035

GGA-353303

Nucleotide Excision Repair

2 of 12

2.41

1.1

0.0094

GGA-73762

RNA Polymerase I Transcription Initiation

2 of 31

1.99

0.74

0.0404

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008023

Transcription elongation factor complex

3 of 37

2.09

1.53

0.0011

GOCC:0016593

Cdc73/Paf1 complex

2 of 8

2.58

1.37

0.0031

GOCC:0016591

RNA polymerase II, holoenzyme

3 of 63

1.86

1.36

0.0018

GOCC:0000109

Nucleotide-excision repair complex

2 of 10

2.48

1.32

0.0037

GOCC:0031464

Cul4A-RING E3 ubiquitin ligase complex

2 of 11

2.44

1.31

0.0039

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0234

DNA repair

3 of 76

1.78

1.08

0.0068

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