ENSNMLP00000031205 protein (Neogobius melanostomus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSNMLP00000031205

annotation not available (269 aa)

Predicted Functional Partners:

ENSNMLP00000021444

0.634

ENSNMLP00000004133

0.624

ENSNMLP00000013801

0.616

ENSNMLP00000001076

0.513

ENSNMLP00000039157

0.513

ENSNMLP00000030607

0.463

ENSNMLP00000018461

0.415

ENSNMLP00000024284

0.415

ENSNMLP00000025512

0.415

ENSNMLP00000044784

0.415

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000001076	ENSNMLP00000013801	MYC binding protein.	annotation not available	0.696
ENSNMLP00000001076	ENSNMLP00000031205	MYC binding protein.	annotation not available	0.513
ENSNMLP00000004133	ENSNMLP00000013801	annotation not available	annotation not available	0.711
ENSNMLP00000004133	ENSNMLP00000018461	annotation not available	Excision repair cross-complementation group 6-like.	0.662
ENSNMLP00000004133	ENSNMLP00000021444	annotation not available	Dpy-30 histone methyltransferase complex regulatory subunit.	0.714
ENSNMLP00000004133	ENSNMLP00000024284	annotation not available	Excision repair cross-complementation group 6-like 2.	0.662
ENSNMLP00000004133	ENSNMLP00000025512	annotation not available	annotation not available	0.686
ENSNMLP00000004133	ENSNMLP00000030607	annotation not available	Protein phosphatase 4, catalytic subunit b.	0.448
ENSNMLP00000004133	ENSNMLP00000031205	annotation not available	annotation not available	0.624
ENSNMLP00000004133	ENSNMLP00000044784	annotation not available	Helicase-like transcription factor.	0.662
ENSNMLP00000013801	ENSNMLP00000001076	annotation not available	MYC binding protein.	0.696
ENSNMLP00000013801	ENSNMLP00000004133	annotation not available	annotation not available	0.711
ENSNMLP00000013801	ENSNMLP00000018461	annotation not available	Excision repair cross-complementation group 6-like.	0.659
ENSNMLP00000013801	ENSNMLP00000021444	annotation not available	Dpy-30 histone methyltransferase complex regulatory subunit.	0.711
ENSNMLP00000013801	ENSNMLP00000024284	annotation not available	Excision repair cross-complementation group 6-like 2.	0.659
ENSNMLP00000013801	ENSNMLP00000025512	annotation not available	annotation not available	0.659
ENSNMLP00000013801	ENSNMLP00000030607	annotation not available	Protein phosphatase 4, catalytic subunit b.	0.448
ENSNMLP00000013801	ENSNMLP00000031205	annotation not available	annotation not available	0.616
ENSNMLP00000013801	ENSNMLP00000039157	annotation not available	annotation not available	0.696
ENSNMLP00000013801	ENSNMLP00000044784	annotation not available	Helicase-like transcription factor.	0.659

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.854

expected number of edges:

11

PPI enrichment p-value:

0.000859

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060382

Regulation of DNA strand elongation

5 of 15

2.71

4.34

6.54e-09

GO:0006275

Regulation of DNA replication

5 of 98

1.9

2.28

1.20e-05

GO:0043967

Histone H4 acetylation

4 of 46

2.13

2.14

5.83e-05

GO:1904507

Positive regulation of telomere maintenance in response to DNA damage

3 of 10

2.67

2.13

0.00012

GO:0006325

Chromatin organization

7 of 430

1.4

1.68

1.16e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031011

Ino80 complex

5 of 13

2.77

5.18

1.69e-10

GO:0070603

SWI/SNF superfamily-type complex

7 of 79

2.14

4.68

3.26e-11

GO:0035267

NuA4 histone acetyltransferase complex

4 of 20

2.49

3.4

3.05e-07

GO:0045095

Keratin filament

4 of 52

2.07

2.55

5.79e-06

GO:0071339

MLL1 complex

3 of 26

2.25

2.17

6.53e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:32306

Keratin, high sulfur B2 protein

4 of 5

3.09

4.02

4.46e-08

CL:6969

Ino80 complex

3 of 6

2.89

2.6

1.74e-05

CL:10875

R2TP complex

2 of 5

2.79

1.47

0.0021

CL:7099

SWI/SNF complex, and Mesenchyme migration

2 of 27

2.06

0.8

0.0318

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5689603

UCH proteinases

4 of 95

1.81

1.55

0.00058

MAP-6805567

Keratinization

4 of 148

1.62

1.28

0.0016

MAP-5688426

Deubiquitination

4 of 304

1.31

0.76

0.0177

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031011

Ino80 complex

7 of 32

2.53

6.64

3.63e-14

GOCC:0070603

SWI/SNF superfamily-type complex

9 of 102

2.13

6.1

1.48e-15

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0233

DNA recombination

4 of 19

2.51

3.4

3.28e-07

KW-0416

Keratin

4 of 34

2.26

2.96

1.36e-06

KW-0234

DNA repair

4 of 80

1.89

2.16

2.34e-05

KW-0805

Transcription regulation

4 of 437

1.15

0.76

0.0100

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13885

Keratin, high sulfur B2 protein

4 of 18

2.54

3.09

1.44e-06

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00268

Actin

3 of 22

2.32

1.83

0.00035

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