ENSNMLP00000032117 protein (Neogobius melanostomus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Coexpression

Experiments

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Score

ENSNMLP00000032117

Centrosomal protein 97. (657 aa)

Predicted Functional Partners:

ENSNMLP00000001005

0.968

ENSNMLP00000036294

0.962

ENSNMLP00000032096

0.960

ENSNMLP00000034861

0.959

ENSNMLP00000026548

0.958

ENSNMLP00000016729

0.954

ENSNMLP00000002177

0.953

ENSNMLP00000021924

0.947

ENSNMLP00000021740

0.945

ENSNMLP00000004187

0.944

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000001005	ENSNMLP00000002177	NADH:ubiquinone oxidoreductase core subunit V1.	NADH:ubiquinone oxidoreductase subunit B5.	0.996
ENSNMLP00000001005	ENSNMLP00000004187	NADH:ubiquinone oxidoreductase core subunit V1.	NADH:ubiquinone oxidoreductase subunit A6.	0.999
ENSNMLP00000001005	ENSNMLP00000016729	NADH:ubiquinone oxidoreductase core subunit V1.	NADH:ubiquinone oxidoreductase subunit B8.	0.999
ENSNMLP00000001005	ENSNMLP00000021740	NADH:ubiquinone oxidoreductase core subunit V1.	INO80 complex subunit Da.	0.999
ENSNMLP00000001005	ENSNMLP00000021924	NADH:ubiquinone oxidoreductase core subunit V1.	NADH:ubiquinone oxidoreductase subunit B10.	0.999
ENSNMLP00000001005	ENSNMLP00000026548	NADH:ubiquinone oxidoreductase core subunit V1.	NADH:ubiquinone oxidoreductase subunit AB1b.	0.998
ENSNMLP00000001005	ENSNMLP00000032096	NADH:ubiquinone oxidoreductase core subunit V1.	annotation not available	0.999
ENSNMLP00000001005	ENSNMLP00000032117	NADH:ubiquinone oxidoreductase core subunit V1.	Centrosomal protein 97.	0.968
ENSNMLP00000001005	ENSNMLP00000034861	NADH:ubiquinone oxidoreductase core subunit V1.	NADH:ubiquinone oxidoreductase core subunit S3.	0.999
ENSNMLP00000001005	ENSNMLP00000036294	NADH:ubiquinone oxidoreductase core subunit V1.	NADH:ubiquinone oxidoreductase core subunit S2.	0.999
ENSNMLP00000002177	ENSNMLP00000001005	NADH:ubiquinone oxidoreductase subunit B5.	NADH:ubiquinone oxidoreductase core subunit V1.	0.996
ENSNMLP00000002177	ENSNMLP00000004187	NADH:ubiquinone oxidoreductase subunit B5.	NADH:ubiquinone oxidoreductase subunit A6.	0.999
ENSNMLP00000002177	ENSNMLP00000016729	NADH:ubiquinone oxidoreductase subunit B5.	NADH:ubiquinone oxidoreductase subunit B8.	0.999
ENSNMLP00000002177	ENSNMLP00000021740	NADH:ubiquinone oxidoreductase subunit B5.	INO80 complex subunit Da.	0.995
ENSNMLP00000002177	ENSNMLP00000021924	NADH:ubiquinone oxidoreductase subunit B5.	NADH:ubiquinone oxidoreductase subunit B10.	0.999
ENSNMLP00000002177	ENSNMLP00000026548	NADH:ubiquinone oxidoreductase subunit B5.	NADH:ubiquinone oxidoreductase subunit AB1b.	0.999
ENSNMLP00000002177	ENSNMLP00000032096	NADH:ubiquinone oxidoreductase subunit B5.	annotation not available	0.999
ENSNMLP00000002177	ENSNMLP00000032117	NADH:ubiquinone oxidoreductase subunit B5.	Centrosomal protein 97.	0.953
ENSNMLP00000002177	ENSNMLP00000034861	NADH:ubiquinone oxidoreductase subunit B5.	NADH:ubiquinone oxidoreductase core subunit S3.	0.999
ENSNMLP00000002177	ENSNMLP00000036294	NADH:ubiquinone oxidoreductase subunit B5.	NADH:ubiquinone oxidoreductase core subunit S2.	0.996

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.927

expected number of edges:

12

PPI enrichment p-value:

4.11e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015813

L-glutamate transmembrane transport

8 of 34

2.68

8.21

4.55e-17

GO:0015804

Neutral amino acid transport

8 of 64

2.41

7.02

1.02e-15

GO:0098657

Import into cell

10 of 158

2.11

6.5

3.39e-17

GO:0140009

L-aspartate import across plasma membrane

5 of 8

3.11

6.13

5.03e-12

GO:0098712

L-glutamate import across plasma membrane

5 of 12

2.93

5.77

1.70e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015501

Glutamate:sodium symporter activity

7 of 14

3.01

8.7

3.97e-17

GO:0015370

Solute:sodium symporter activity

10 of 102

2.3

8.03

1.67e-19

GO:0005313

L-glutamate transmembrane transporter activity

7 of 25

2.76

7.79

6.81e-16

GO:0015175

Neutral amino acid transmembrane transporter activity

7 of 62

2.37

6.14

9.50e-14

GO:0008509

Anion transmembrane transporter activity

10 of 358

1.76

4.43

2.94e-15

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045202

Synapse

10 of 1052

1.29

2.02

6.44e-10

GO:0098793

Presynapse

5 of 385

1.43

1.51

8.55e-05

GO:0005887

Integral component of plasma membrane

9 of 1342

1.14

1.44

1.90e-07

GO:0032809

Neuronal cell body membrane

2 of 23

2.25

1.19

0.0060

GO:0045121

Membrane raft

3 of 138

1.65

1.13

0.0042

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:39553

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

10 of 20

3.01

12.83

1.55e-25

CL:39555

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

8 of 15

3.04

10.29

3.08e-20

CL:39557

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

7 of 10

3.16

9.3

4.84e-18

CL:39559

D-amino acid transport, and Dopamine:sodium symporter activity

3 of 5

3.09

3.14

1.97e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

7 of 47

2.49

6.68

1.89e-14

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-210500

Glutamate Neurotransmitter Release Cycle

7 of 52

2.44

6.21

1.54e-13

MAP-112310

Neurotransmitter release cycle

7 of 110

2.12

4.8

1.11e-11

MAP-425393

Transport of inorganic cations/anions and amino acids/oligopeptides

8 of 188

1.94

4.51

2.46e-12

MAP-425407

SLC-mediated transmembrane transport

10 of 424

1.69

3.85

1.10e-13

MAP-112315

Transmission across Chemical Synapses

8 of 444

1.57

2.79

1.04e-09

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 11939

0.28

0.25

0.0081

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005887

Integral component of plasma membrane

5 of 403

1.41

1.19

0.0012

GOCC:0032809

Neuronal cell body membrane

2 of 17

2.38

1.15

0.0077

GOCC:0005886

Plasma membrane

8 of 2464

0.82

0.67

0.0012

GOCC:0016020

Membrane

10 of 4744

0.64

0.51

0.0012

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0769

Symport

10 of 60

2.53

10.07

1.58e-22

KW-1133

Transmembrane helix

11 of 6003

0.58

0.5

5.45e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00375

Sodium:dicarboxylate symporter family

7 of 17

2.93

8.11

3.96e-16

PF00209

Sodium:neurotransmitter symporter family

3 of 44

2.15

1.49

0.0014

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