ENSNMLP00000033948 protein (Neogobius melanostomus)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

ENSNMLP00000033948

K(lysine) acetyltransferase 8. (498 aa)

Predicted Functional Partners:

ENSNMLP00000029175

0.967

ENSNMLP00000022009

0.966

ENSNMLP00000029148

0.966

ENSNMLP00000012982

0.963

MSL3

0.960

ENSNMLP00000014406

0.954

ENSNMLP00000031101

0.954

ENSNMLP00000036843

0.954

ENSNMLP00000016356

0.953

ENSNMLP00000024854

0.952

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSNMLP00000012982	ENSNMLP00000014406	ENSNMLP00000012982	ENSNMLP00000014406	Mortality factor 4 like 1.	MRG/MORF4L binding protein.	0.994
ENSNMLP00000012982	ENSNMLP00000016356	ENSNMLP00000012982	ENSNMLP00000016356	Mortality factor 4 like 1.	Enhancer of polycomb homolog 1 (Drosophila) a.	0.981
ENSNMLP00000012982	ENSNMLP00000022009	ENSNMLP00000012982	ENSNMLP00000022009	Mortality factor 4 like 1.	MYST/Esa1-associated factor 6.	0.994
ENSNMLP00000012982	ENSNMLP00000024854	ENSNMLP00000012982	ENSNMLP00000024854	Mortality factor 4 like 1.	annotation not available	0.921
ENSNMLP00000012982	ENSNMLP00000029148	ENSNMLP00000012982	ENSNMLP00000029148	Mortality factor 4 like 1.	RuvB-like AAA ATPase 1.	0.980
ENSNMLP00000012982	ENSNMLP00000029175	ENSNMLP00000012982	ENSNMLP00000029175	Mortality factor 4 like 1.	DNA methyltransferase 1 associated protein 1.	0.994
ENSNMLP00000012982	ENSNMLP00000031101	ENSNMLP00000012982	ENSNMLP00000031101	Mortality factor 4 like 1.	annotation not available	0.962
ENSNMLP00000012982	ENSNMLP00000033948	ENSNMLP00000012982	ENSNMLP00000033948	Mortality factor 4 like 1.	K(lysine) acetyltransferase 8.	0.963
ENSNMLP00000012982	ENSNMLP00000036843	ENSNMLP00000012982	ENSNMLP00000036843	Mortality factor 4 like 1.	annotation not available	0.962
ENSNMLP00000012982	MSL3	ENSNMLP00000012982	ENSNMLP00000000835	Mortality factor 4 like 1.	MSL complex subunit 3.	0.898
ENSNMLP00000014406	ENSNMLP00000012982	ENSNMLP00000014406	ENSNMLP00000012982	MRG/MORF4L binding protein.	Mortality factor 4 like 1.	0.994
ENSNMLP00000014406	ENSNMLP00000016356	ENSNMLP00000014406	ENSNMLP00000016356	MRG/MORF4L binding protein.	Enhancer of polycomb homolog 1 (Drosophila) a.	0.963
ENSNMLP00000014406	ENSNMLP00000022009	ENSNMLP00000014406	ENSNMLP00000022009	MRG/MORF4L binding protein.	MYST/Esa1-associated factor 6.	0.991
ENSNMLP00000014406	ENSNMLP00000029148	ENSNMLP00000014406	ENSNMLP00000029148	MRG/MORF4L binding protein.	RuvB-like AAA ATPase 1.	0.989
ENSNMLP00000014406	ENSNMLP00000029175	ENSNMLP00000014406	ENSNMLP00000029175	MRG/MORF4L binding protein.	DNA methyltransferase 1 associated protein 1.	0.994
ENSNMLP00000014406	ENSNMLP00000031101	ENSNMLP00000014406	ENSNMLP00000031101	MRG/MORF4L binding protein.	annotation not available	0.934
ENSNMLP00000014406	ENSNMLP00000033948	ENSNMLP00000014406	ENSNMLP00000033948	MRG/MORF4L binding protein.	K(lysine) acetyltransferase 8.	0.954
ENSNMLP00000014406	ENSNMLP00000036843	ENSNMLP00000014406	ENSNMLP00000036843	MRG/MORF4L binding protein.	annotation not available	0.934
ENSNMLP00000014406	MSL3	ENSNMLP00000014406	ENSNMLP00000000835	MRG/MORF4L binding protein.	MSL complex subunit 3.	0.967
ENSNMLP00000016356	ENSNMLP00000012982	ENSNMLP00000016356	ENSNMLP00000012982	Enhancer of polycomb homolog 1 (Drosophila) a.	Mortality factor 4 like 1.	0.981

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.893

expected number of edges:

10

PPI enrichment p-value:

0.0337

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005223

Intracellular cGMP-activated cation channel activity

2 of 7

2.68

1.1

0.0101

GO:0005222

Intracellular cAMP-activated cation channel activity

2 of 9

2.57

1.09

0.0101

GO:0030553

cGMP binding

2 of 16

2.32

1.05

0.0117

GO:0015106

Bicarbonate transmembrane transporter activity

2 of 19

2.25

0.99

0.0146

GO:0099094

Ligand-gated cation channel activity

3 of 109

1.67

0.96

0.0109

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017071

Intracellular cyclic nucleotide activated cation channel complex

2 of 5

2.83

1.14

0.0088

GO:0036126

Sperm flagellum

3 of 98

1.71

0.9

0.0164

GO:0097225

Sperm midpiece

2 of 29

2.07

0.72

0.0459

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:24164424

(2013) Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating.

5 of 14

2.78

4.63

2.08e-09

PMID:33362798

(2020) Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System.

4 of 13

2.72

3.35

5.66e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19067

Mixed, incl. Bicarbonate transporters, and Ral GTPase-activating protein subunit alpha/beta, N-terminal domain

3 of 17

2.47

1.71

0.00069

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 11007

0.23

0.22

0.0282

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017071

Intracellular cyclic nucleotide activated cation channel complex

2 of 5

2.83

1.09

0.0106

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0406

Ion transport

4 of 286

1.37

0.97

0.0051

KW-0813

Transport

5 of 615

1.14

0.83

0.0051

KW-0407

Ion channel

3 of 198

1.41

0.77

0.0207

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000595

Cyclic nucleotide-binding domain

3 of 26

2.29

1.34

0.0032

IPR018490

Cyclic nucleotide-binding domain superfamily

3 of 29

2.24

1.33

0.0032

IPR014710

RmlC-like jelly roll fold

3 of 37

2.14

1.31

0.0032

IPR032406

Cyclic nucleotide-gated channel, C-terminal leucine zipper domain

2 of 4

2.93

1.2

0.0069

IPR018488

Cyclic nucleotide-binding, conserved site

2 of 13

2.42

0.82

0.0319

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00100

Cyclic nucleotide-monophosphate binding domain

3 of 26

2.29

1.78

0.00042

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