ENSNMLP00000035528 protein (Neogobius melanostomus)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

ENSNMLP00000035528

Dihydropyrimidinase like 2b. (603 aa)

Predicted Functional Partners:

ENSNMLP00000001409

0.961

ENSNMLP00000042437

0.921

ENSNMLP00000021697

0.903

ENSNMLP00000028536

0.903

ENSNMLP00000037770

0.903

ENSNMLP00000003663

0.835

ENSNMLP00000005044

0.823

ENSNMLP00000016612

0.823

ENSNMLP00000044228

0.823

ENSNMLP00000022162

0.819

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000001409	ENSNMLP00000003663	Dihydroorotate dehydrogenase.	Cytochrome b5 reductase 4.	0.997
ENSNMLP00000001409	ENSNMLP00000005044	Dihydroorotate dehydrogenase.	Cytochrome b5 reductase 2.	0.995
ENSNMLP00000001409	ENSNMLP00000016612	Dihydroorotate dehydrogenase.	Oxidoreductase NAD-binding domain containing 1.	0.995
ENSNMLP00000001409	ENSNMLP00000021697	Dihydroorotate dehydrogenase.	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	0.992
ENSNMLP00000001409	ENSNMLP00000028536	Dihydroorotate dehydrogenase.	G protein-coupled receptor 143.	0.988
ENSNMLP00000001409	ENSNMLP00000035528	Dihydroorotate dehydrogenase.	Dihydropyrimidinase like 2b.	0.961
ENSNMLP00000001409	ENSNMLP00000037770	Dihydroorotate dehydrogenase.	annotation not available	0.988
ENSNMLP00000001409	ENSNMLP00000042437	Dihydroorotate dehydrogenase.	Uridine monophosphate synthetase.	0.999
ENSNMLP00000001409	ENSNMLP00000044228	Dihydroorotate dehydrogenase.	Cytochrome b5 reductase 3.	0.995
ENSNMLP00000003663	ENSNMLP00000001409	Cytochrome b5 reductase 4.	Dihydroorotate dehydrogenase.	0.997
ENSNMLP00000003663	ENSNMLP00000005044	Cytochrome b5 reductase 4.	Cytochrome b5 reductase 2.	0.909
ENSNMLP00000003663	ENSNMLP00000016612	Cytochrome b5 reductase 4.	Oxidoreductase NAD-binding domain containing 1.	0.837
ENSNMLP00000003663	ENSNMLP00000021697	Cytochrome b5 reductase 4.	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	0.958
ENSNMLP00000003663	ENSNMLP00000028536	Cytochrome b5 reductase 4.	G protein-coupled receptor 143.	0.958
ENSNMLP00000003663	ENSNMLP00000035528	Cytochrome b5 reductase 4.	Dihydropyrimidinase like 2b.	0.835
ENSNMLP00000003663	ENSNMLP00000037770	Cytochrome b5 reductase 4.	annotation not available	0.958
ENSNMLP00000003663	ENSNMLP00000042437	Cytochrome b5 reductase 4.	Uridine monophosphate synthetase.	0.985
ENSNMLP00000003663	ENSNMLP00000044228	Cytochrome b5 reductase 4.	Cytochrome b5 reductase 3.	0.909
ENSNMLP00000005044	ENSNMLP00000001409	Cytochrome b5 reductase 2.	Dihydroorotate dehydrogenase.	0.995
ENSNMLP00000005044	ENSNMLP00000003663	Cytochrome b5 reductase 2.	Cytochrome b5 reductase 4.	0.909

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.815

expected number of edges:

14

PPI enrichment p-value:

4.8e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007259

Receptor signaling pathway via JAK-STAT

6 of 20

2.79

5.97

4.53e-12

GO:0019221

Cytokine-mediated signaling pathway

7 of 212

1.83

3.28

6.13e-09

GO:0007260

Tyrosine phosphorylation of STAT protein

3 of 4

3.19

2.98

3.96e-06

GO:0060397

Growth hormone receptor signaling pathway via JAK-STAT

3 of 5

3.09

2.9

5.43e-06

GO:0043434

Response to peptide hormone

5 of 167

1.79

2.19

1.06e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005131

Growth hormone receptor binding

3 of 5

3.09

2.7

1.24e-05

GO:0004715

Non-membrane spanning protein tyrosine kinase activity

3 of 47

2.12

1.49

0.0014

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22435

Receptor signaling pathway via JAK-STAT, and 1-phosphatidylinositol-3-kinase regulator activity

8 of 27

2.78

8.91

3.45e-18

CL:22438

Receptor signaling pathway via JAK-STAT

7 of 14

3.01

8.69

4.13e-17

CL:22431

Cytokine-mediated signaling pathway, and 1-phosphatidylinositol-3-kinase regulator activity

10 of 101

2.31

7.98

2.66e-19

CL:22456

STAT protein, all-alpha domain, and Protein kinase

4 of 5

3.22

4.83

1.57e-09

CL:22440

Growth hormone receptor signaling pathway via JAK-STAT, and Suppressor of cytokine signalling

2 of 6

2.84

1.45

0.0023

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04217

Necroptosis

8 of 255

1.81

3.94

9.40e-12

map05168

Herpes simplex virus 1 infection

8 of 445

1.57

2.86

3.73e-10

map04625

C-type lectin receptor signaling pathway

5 of 194

1.72

2.43

1.08e-06

map04621

NOD-like receptor signaling pathway

7 of 445

1.51

2.4

2.44e-08

map04620

Toll-like receptor signaling pathway

3 of 120

1.71

1.41

0.00098

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-909733

Interferon alpha/beta signaling

7 of 48

2.48

6.24

1.84e-13

MAP-877312

Regulation of IFNG signaling

5 of 10

3.01

5.9

1.16e-11

MAP-8854691

Interleukin-20 family signaling

6 of 33

2.57

5.76

4.46e-12

MAP-913531

Interferon Signaling

8 of 177

1.97

4.6

2.31e-12

MAP-877300

Interferon gamma signaling

5 of 48

2.33

4.04

7.36e-09

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0727

SH2 domain

5 of 121

1.93

2.76

7.79e-07

KW-0829

Tyrosine-protein kinase

3 of 81

1.88

1.42

0.0014

KW-0010

Activator

2 of 56

1.87

0.73

0.0408

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09294

Interferon-alpha/beta receptor, fibronectin type III

2 of 7

2.77

1.05

0.0125

PF02864

STAT protein, DNA binding domain

2 of 6

2.84

1.05

0.0125

PF01108

Tissue factor

2 of 6

2.84

1.05

0.0125

PF01017

STAT protein, all-alpha domain

2 of 8

2.71

1.05

0.0125

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00252

Src homology 2 domains

6 of 110

2.05

3.73

4.98e-09

SM00221

Protein kinase

3 of 3

3.31

3.44

5.89e-07

SM00295

Band 4.1 homologues

3 of 38

2.21

1.91

0.00021

SM00964

STAT protein, protein interaction domain

2 of 6

2.84

1.65

0.0010

SM01243

Interferon-regulatory factor 3

2 of 10

2.61

1.53

0.0016

(more ...)

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