ENSNMLP00000036552 protein (Neogobius melanostomus)

Nodes:

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ENSNMLP00000036552

annotation not available (92 aa)

Predicted Functional Partners:

ENSNMLP00000010912

0.713

ENSNMLP00000016890

0.673

ENSNMLP00000025394

0.670

ENSNMLP00000012174

0.663

ENSNMLP00000030894

0.662

ENSNMLP00000027455

0.642

ENSNMLP00000038102

0.639

ENSNMLP00000022224

0.638

ENSNMLP00000024375

0.628

ENSNMLP00000005408

0.627

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000005408	ENSNMLP00000010912	Claudin 15-like a.	Peroxisomal biogenesis factor 19.	0.787
ENSNMLP00000005408	ENSNMLP00000012174	Claudin 15-like a.	Peroxisomal biogenesis factor 13.	0.722
ENSNMLP00000005408	ENSNMLP00000016890	Claudin 15-like a.	annotation not available	0.865
ENSNMLP00000005408	ENSNMLP00000022224	Claudin 15-like a.	Claudin c.	0.838
ENSNMLP00000005408	ENSNMLP00000025394	Claudin 15-like a.	Peroxisomal biogenesis factor 3.	0.750
ENSNMLP00000005408	ENSNMLP00000027455	Claudin 15-like a.	annotation not available	0.845
ENSNMLP00000005408	ENSNMLP00000030894	Claudin 15-like a.	Peroxisomal biogenesis factor 12.	0.698
ENSNMLP00000005408	ENSNMLP00000036552	Claudin 15-like a.	annotation not available	0.627
ENSNMLP00000005408	ENSNMLP00000038102	Claudin 15-like a.	Claudin 18.	0.846
ENSNMLP00000010912	ENSNMLP00000005408	Peroxisomal biogenesis factor 19.	Claudin 15-like a.	0.787
ENSNMLP00000010912	ENSNMLP00000012174	Peroxisomal biogenesis factor 19.	Peroxisomal biogenesis factor 13.	0.998
ENSNMLP00000010912	ENSNMLP00000022224	Peroxisomal biogenesis factor 19.	Claudin c.	0.463
ENSNMLP00000010912	ENSNMLP00000025394	Peroxisomal biogenesis factor 19.	Peroxisomal biogenesis factor 3.	0.999
ENSNMLP00000010912	ENSNMLP00000030894	Peroxisomal biogenesis factor 19.	Peroxisomal biogenesis factor 12.	0.990
ENSNMLP00000010912	ENSNMLP00000036552	Peroxisomal biogenesis factor 19.	annotation not available	0.713
ENSNMLP00000010912	ENSNMLP00000038102	Peroxisomal biogenesis factor 19.	Claudin 18.	0.463
ENSNMLP00000012174	ENSNMLP00000005408	Peroxisomal biogenesis factor 13.	Claudin 15-like a.	0.722
ENSNMLP00000012174	ENSNMLP00000010912	Peroxisomal biogenesis factor 13.	Peroxisomal biogenesis factor 19.	0.998
ENSNMLP00000012174	ENSNMLP00000025394	Peroxisomal biogenesis factor 13.	Peroxisomal biogenesis factor 3.	0.977
ENSNMLP00000012174	ENSNMLP00000030894	Peroxisomal biogenesis factor 13.	Peroxisomal biogenesis factor 12.	0.989

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033627

Cell adhesion mediated by integrin

8 of 33

2.61

7.64

3.90e-16

GO:0007229

Integrin-mediated signaling pathway

8 of 54

2.39

6.65

6.87e-15

GO:0007160

Cell-matrix adhesion

8 of 65

2.31

6.29

1.82e-14

GO:0007155

Cell adhesion

10 of 572

1.46

2.72

1.61e-11

GO:0016477

Cell migration

7 of 521

1.35

1.65

6.18e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005178

Integrin binding

8 of 81

2.22

5.78

9.11e-14

GO:0044877

Protein-containing complex binding

9 of 828

1.26

1.77

3.48e-08

GO:0005515

Protein binding

11 of 5587

0.52

0.42

0.0011

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008305

Integrin complex

8 of 28

2.68

8.58

6.46e-18

GO:0005925

Focal adhesion

10 of 101

2.22

7.47

5.88e-19

GO:0009986

Cell surface

8 of 437

1.48

2.5

2.40e-09

GO:0071944

Cell periphery

11 of 4676

0.59

0.53

2.65e-05

GO:0005886

Plasma membrane

10 of 4185

0.6

0.51

0.00028

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31792290

(2019) General structural features that regulate integrin affinity revealed by atypical alphaVbeta8.

8 of 11

3.08

10.35

2.97e-20

PMID:28472103

(2017) Tgm1-like transglutaminases in tilapia (Oreochromis mossambicus).

2 of 5

2.82

1.42

0.0026

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4991

Integrin complex, and MET activates PTK2 signaling

8 of 47

2.45

6.98

2.42e-15

CL:4993

Integrin complex, and MET activates PTK2 signaling

7 of 36

2.51

6.58

4.19e-14

CL:4994

Integrin complex, and TSP type-3 repeat

4 of 18

2.57

3.57

1.63e-07

CL:5031

MET activates PTK2 signaling, and Integrin alpha chain, C-terminal cytoplasmic region, conserved site

3 of 14

2.55

2.41

3.22e-05

CL:28046

Mixed, incl. Filamin family, and Ajuba-like

2 of 6

2.74

1.43

0.0025

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04510

Focal adhesion

10 of 228

1.86

5.13

2.35e-16

map04512

ECM-receptor interaction

8 of 140

1.98

4.91

2.32e-13

map04810

Regulation of actin cytoskeleton

8 of 254

1.72

3.6

1.60e-11

map04514

Cell adhesion molecules

4 of 210

1.5

1.46

0.00027

map04145

Phagosome

4 of 264

1.4

1.28

0.00053

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-216083

Integrin cell surface interactions

7 of 71

2.22

5.03

1.02e-11

MAP-2173789

TGF-beta receptor signaling activates SMADs

4 of 40

2.22

2.67

5.16e-06

MAP-1474244

Extracellular matrix organization

8 of 376

1.55

2.63

4.42e-09

MAP-2129379

Molecules associated with elastic fibres

4 of 46

2.16

2.59

6.56e-06

MAP-1566948

Elastic fibre formation

4 of 57

2.07

2.42

1.18e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032587

Ruffle membrane

3 of 24

2.32

1.68

0.00070

GOCC:0008305

Integrin complex

3 of 26

2.28

1.67

0.00070

GOCC:0098797

Plasma membrane protein complex

4 of 347

1.28

0.87

0.0077

GOCC:0005886

Plasma membrane

7 of 1977

0.77

0.54

0.0077

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0401

Integrin

8 of 25

2.73

8.88

2.34e-18

KW-0130

Cell adhesion

8 of 48

2.44

7.48

1.19e-16

KW-1015

Disulfide bond

6 of 1100

0.96

0.77

0.0018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07974

EGF-like domain

4 of 5

3.13

4.24

1.85e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002369

Integrin beta subunit, VWA domain

8 of 9

3.17

10.22

8.32e-20

IPR015812

Integrin beta subunit

8 of 10

3.13

10.17

8.32e-20

IPR036349

Integrin beta tail domain superfamily

7 of 8

3.16

8.87

3.36e-17

IPR033760

Integrin beta N-terminal

7 of 8

3.16

8.87

3.36e-17

IPR012896

Integrin beta subunit, tail

7 of 8

3.16

8.87

3.36e-17

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01242

This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.

7 of 8

3.16

9.11

1.15e-17

SM01241

Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion. Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit. Several variations of the ...

6 of 7

3.16

7.7

5.64e-15

SM00187

Integrin beta subunits (N-terminal portion of extracellular region)

6 of 7

3.16

7.7

5.64e-15

SM00001

EGF domain, unclasssified subfamily

5 of 87

1.98

3.01

2.42e-07

SM00181

Epidermal growth factor-like domain.

3 of 206

1.39

0.68

0.0339

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