ENSNMLP00000039710 protein (Neogobius melanostomus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSNMLP00000039710

annotation not available (272 aa)

Predicted Functional Partners:

ENSNMLP00000025912

0.755

ENSNMLP00000016805

0.707

ENSNMLP00000009584

0.693

ENSNMLP00000001175

0.692

ENSNMLP00000018393

0.663

ENSNMLP00000009456

0.659

ENSNMLP00000001079

0.580

ENSNMLP00000041787

0.577

ENSNMLP00000029013

0.574

ENSNMLP00000007928

0.565

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000001079	ENSNMLP00000001175	Ribosomal protein S27a.	annotation not available	0.558
ENSNMLP00000001079	ENSNMLP00000007928	Ribosomal protein S27a.	Ribosomal protein L8.	0.999
ENSNMLP00000001079	ENSNMLP00000016805	Ribosomal protein S27a.	BRCA1 associated RING domain 1.	0.970
ENSNMLP00000001079	ENSNMLP00000018393	Ribosomal protein S27a.	Ribosomal protein L21.	0.999
ENSNMLP00000001079	ENSNMLP00000025912	Ribosomal protein S27a.	FAU ubiquitin like and ribosomal protein S30 fusion a.	0.999
ENSNMLP00000001079	ENSNMLP00000039710	Ribosomal protein S27a.	annotation not available	0.580
ENSNMLP00000001175	ENSNMLP00000001079	annotation not available	Ribosomal protein S27a.	0.558
ENSNMLP00000001175	ENSNMLP00000007928	annotation not available	Ribosomal protein L8.	0.572
ENSNMLP00000001175	ENSNMLP00000009456	annotation not available	Recombination activating gene 2.	0.516
ENSNMLP00000001175	ENSNMLP00000009584	annotation not available	Si:ch211-152c8.4.	0.998
ENSNMLP00000001175	ENSNMLP00000016805	annotation not available	BRCA1 associated RING domain 1.	0.634
ENSNMLP00000001175	ENSNMLP00000039710	annotation not available	annotation not available	0.692
ENSNMLP00000007928	ENSNMLP00000001079	Ribosomal protein L8.	Ribosomal protein S27a.	0.999
ENSNMLP00000007928	ENSNMLP00000001175	Ribosomal protein L8.	annotation not available	0.572
ENSNMLP00000007928	ENSNMLP00000009584	Ribosomal protein L8.	Si:ch211-152c8.4.	0.505
ENSNMLP00000007928	ENSNMLP00000016805	Ribosomal protein L8.	BRCA1 associated RING domain 1.	0.799
ENSNMLP00000007928	ENSNMLP00000018393	Ribosomal protein L8.	Ribosomal protein L21.	0.999
ENSNMLP00000007928	ENSNMLP00000025912	Ribosomal protein L8.	FAU ubiquitin like and ribosomal protein S30 fusion a.	0.999
ENSNMLP00000007928	ENSNMLP00000039710	Ribosomal protein L8.	annotation not available	0.565
ENSNMLP00000009456	ENSNMLP00000001175	Recombination activating gene 2.	annotation not available	0.516

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.786

expected number of edges:

18

PPI enrichment p-value:

0.000201

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000904

Cell morphogenesis involved in differentiation

7 of 445

1.51

1.98

2.98e-06

GO:0048667

Cell morphogenesis involved in neuron differentiation

6 of 368

1.53

1.79

2.14e-05

GO:0006935

Chemotaxis

6 of 365

1.53

1.79

2.14e-05

GO:0048812

Neuron projection morphogenesis

6 of 394

1.5

1.75

2.14e-05

GO:0030182

Neuron differentiation

7 of 820

1.24

1.39

2.14e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008201

Heparin binding

5 of 132

1.89

2.33

8.79e-06

GO:0005509

Calcium ion binding

5 of 739

1.14

0.76

0.0096

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10656

Mixed, incl. Leucine rich repeat N-terminal domain, and Kringle

9 of 130

2.15

6.1

2.37e-15

CL:10858

Mixed, incl. Signaling by ROBO receptors, and SDK interactions

6 of 29

2.63

5.94

2.60e-12

CL:10906

Mixed, incl. G2F domain, and Regulation of neuron migration

3 of 5

3.09

3.06

2.71e-06

CL:10685

Mixed, incl. Kringle, and Von Willebrand factor (vWF) type D domain

3 of 19

2.51

2.24

6.59e-05

CL:10859

Mixed, incl. Signaling by ROBO receptors, and SDK interactions

3 of 24

2.41

2.1

0.00011

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-422475

Axon guidance

7 of 413

1.54

2.24

3.72e-07

MAP-9675108

Nervous system development

7 of 427

1.53

2.21

3.72e-07

MAP-1266738

Developmental Biology

7 of 705

1.31

1.6

4.87e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0433

Leucine-rich repeat

6 of 176

1.85

3.07

3.90e-08

KW-0677

Repeat

7 of 1223

1.07

1.08

6.58e-05

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00013

Leucine rich repeat N-terminal domain

7 of 122

2.07

4.61

1.86e-11

SM00369

Leucine-rich repeats, typical (most populated) subfamily

8 of 183

1.95

4.55

2.49e-12

SM00370

Leucine-rich repeats, outliers

8 of 336

1.69

3.34

9.63e-11

SM00408

Immunoglobulin C-2 Type

4 of 230

1.55

1.39

0.00060

SM00082

Leucine rich repeat C-terminal domain

3 of 116

1.73

1.21

0.0031

(more ...)

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