ENSNMLP00000040347 protein (Neogobius melanostomus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

ENSNMLP00000040347

annotation not available (200 aa)

Predicted Functional Partners:

ENSNMLP00000004068

0.949

ENSNMLP00000011995

0.939

ENSNMLP00000031124

0.939

ENSNMLP00000010104

0.916

ENSNMLP00000022281

0.916

ENSNMLP00000042683

0.916

ENSNMLP00000041503

0.892

ENSNMLP00000024334

0.851

ENSNMLP00000001022

0.842

ENSNMLP00000000572

0.834

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000000572	ENSNMLP00000001022	Elongin A.	annotation not available	0.869
ENSNMLP00000000572	ENSNMLP00000004068	Elongin A.	ELL associated factor 1.	0.882
ENSNMLP00000000572	ENSNMLP00000010104	Elongin A.	Elongation factor RNA polymerase II.	0.879
ENSNMLP00000000572	ENSNMLP00000022281	Elongin A.	Si:ch211-13k12.2.	0.841
ENSNMLP00000000572	ENSNMLP00000024334	Elongin A.	annotation not available	0.879
ENSNMLP00000000572	ENSNMLP00000031124	Elongin A.	ELL associated factor 2.	0.882
ENSNMLP00000000572	ENSNMLP00000040347	Elongin A.	annotation not available	0.834
ENSNMLP00000000572	ENSNMLP00000042683	Elongin A.	annotation not available	0.841
ENSNMLP00000001022	ENSNMLP00000000572	annotation not available	Elongin A.	0.869
ENSNMLP00000001022	ENSNMLP00000004068	annotation not available	ELL associated factor 1.	0.978
ENSNMLP00000001022	ENSNMLP00000010104	annotation not available	Elongation factor RNA polymerase II.	0.946
ENSNMLP00000001022	ENSNMLP00000011995	annotation not available	Interactor of little elongator complex ELL subunit 2.	0.865
ENSNMLP00000001022	ENSNMLP00000022281	annotation not available	Si:ch211-13k12.2.	0.946
ENSNMLP00000001022	ENSNMLP00000024334	annotation not available	annotation not available	0.877
ENSNMLP00000001022	ENSNMLP00000031124	annotation not available	ELL associated factor 2.	0.937
ENSNMLP00000001022	ENSNMLP00000040347	annotation not available	annotation not available	0.842
ENSNMLP00000001022	ENSNMLP00000041503	annotation not available	Zinc finger CCCH-type containing 6.	0.828
ENSNMLP00000001022	ENSNMLP00000042683	annotation not available	annotation not available	0.946
ENSNMLP00000004068	ENSNMLP00000000572	ELL associated factor 1.	Elongin A.	0.882
ENSNMLP00000004068	ENSNMLP00000001022	ELL associated factor 1.	annotation not available	0.978

page 1 of 6

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000103

Sulfate assimilation

6 of 6

2.55

5.12

9.48e-11

GO:0070814

Hydrogen sulfide biosynthetic process

5 of 5

2.55

4.19

8.49e-09

GO:0019419

Sulfate reduction

3 of 3

2.55

2.26

6.25e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004781

Sulfate adenylyltransferase (ATP) activity

5 of 5

2.55

4.17

9.52e-09

GO:0003924

GTPase activity

3 of 20

1.73

1.22

0.0030

GO:0005525

GTP binding

3 of 30

1.55

1.03

0.0061

GO:0016772

Transferase activity, transferring phosphorus-containing groups

6 of 202

1.03

0.87

0.00097

GO:0005524

ATP binding

6 of 297

0.86

0.62

0.0061

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009336

Sulfate adenylyltransferase complex (ATP)

3 of 3

2.55

2.38

3.72e-05

GO:0005737

Cytoplasm

9 of 1157

0.44

0.33

0.0116

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1876

Sulfate assimilation, and Nitrite/Sulfite reductase ferredoxin-like domain superfamily

8 of 8

2.55

7.31

1.31e-15

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00920

Sulfur metabolism

8 of 39

1.87

4.2

4.46e-12

map00261

Monobactam biosynthesis

4 of 11

2.11

2.79

1.87e-06

map00450

Selenocompound metabolism

4 of 28

1.71

1.96

2.89e-05

map00230

Purine metabolism

6 of 87

1.39

1.81

1.96e-06

map01120

Microbial metabolism in diverse environments

9 of 323

1.0

1.14

5.76e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009336

Sulfate adenylyltransferase complex (ATP)

3 of 3

2.55

2.16

9.72e-05

GOCC:0005737

Cytoplasm

9 of 944

0.53

0.38

0.0093

GOCC:0005622

Intracellular

10 of 1341

0.43

0.32

0.0124

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0548

Nucleotidyltransferase

4 of 31

1.66

1.56

0.00032

KW-0067

ATP-binding

5 of 231

0.89

0.53

0.0249

KW-0808

Transferase

6 of 435

0.69

0.42

0.0318

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01507

Phosphoadenosine phosphosulfate reductase family

3 of 3

2.55

2.01

0.00019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002500

Phosphoadenosine phosphosulphate reductase

3 of 3

2.55

1.8

0.00048

IPR044139

Sulfate adenylyltransferase subunit CysN, Domain III

2 of 2

2.55

0.83

0.0314

IPR044138

Sulfate adenylyltransferase subunit CysN, Domain II

2 of 2

2.55

0.83

0.0314

IPR041757

Sulfate adenylyltransferase subunit CysN, GTP-binding domain

2 of 2

2.55

0.83

0.0314

IPR011784

Sulphate adenylyltransferase, small subunit

2 of 2

2.55

0.83

0.0314

(more ...)

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