ENSNMLP00000044712 protein (Neogobius melanostomus)

Nodes:

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white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ENSNMLP00000044712

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2b. (1042 aa)

Predicted Functional Partners:

ENSNMLP00000038436

0.807

ENSNMLP00000023221

0.781

ENSNMLP00000035582

0.781

ENSNMLP00000025755

0.779

ENSNMLP00000029985

0.779

ENSNMLP00000035623

0.779

ENSNMLP00000018965

0.778

ENSNMLP00000035720

0.758

ENSNMLP00000009778

0.681

ENSNMLP00000014223

0.681

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000009778	ENSNMLP00000044712	Superoxide dismutase 1, soluble.	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2b.	0.681
ENSNMLP00000014223	ENSNMLP00000044712	Superoxide dismutase 3, extracellular b.	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2b.	0.681
ENSNMLP00000018965	ENSNMLP00000025755	annotation not available	ATPase plasma membrane Ca2+ transporting 3b.	0.588
ENSNMLP00000018965	ENSNMLP00000029985	annotation not available	annotation not available	0.805
ENSNMLP00000018965	ENSNMLP00000035582	annotation not available	ATPase plasma membrane Ca2+ transporting 2.	0.589
ENSNMLP00000018965	ENSNMLP00000035623	annotation not available	annotation not available	0.587
ENSNMLP00000018965	ENSNMLP00000035720	annotation not available	Transmembrane protein 165.	0.430
ENSNMLP00000018965	ENSNMLP00000038436	annotation not available	ATP synthase F1 subunit alpha.	0.499
ENSNMLP00000018965	ENSNMLP00000044712	annotation not available	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2b.	0.778
ENSNMLP00000023221	ENSNMLP00000025755	annotation not available	ATPase plasma membrane Ca2+ transporting 3b.	0.589
ENSNMLP00000023221	ENSNMLP00000029985	annotation not available	annotation not available	0.805
ENSNMLP00000023221	ENSNMLP00000035582	annotation not available	ATPase plasma membrane Ca2+ transporting 2.	0.589
ENSNMLP00000023221	ENSNMLP00000035623	annotation not available	annotation not available	0.587
ENSNMLP00000023221	ENSNMLP00000035720	annotation not available	Transmembrane protein 165.	0.430
ENSNMLP00000023221	ENSNMLP00000038436	annotation not available	ATP synthase F1 subunit alpha.	0.499
ENSNMLP00000023221	ENSNMLP00000044712	annotation not available	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2b.	0.781
ENSNMLP00000025755	ENSNMLP00000018965	ATPase plasma membrane Ca2+ transporting 3b.	annotation not available	0.588
ENSNMLP00000025755	ENSNMLP00000023221	ATPase plasma membrane Ca2+ transporting 3b.	annotation not available	0.589
ENSNMLP00000025755	ENSNMLP00000029985	ATPase plasma membrane Ca2+ transporting 3b.	annotation not available	0.783
ENSNMLP00000025755	ENSNMLP00000035720	ATPase plasma membrane Ca2+ transporting 3b.	Transmembrane protein 165.	0.430

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

2.19e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 429

1.63

3.41

2.71e-12

GO:0002181

Cytoplasmic translation

4 of 79

1.96

2.05

6.04e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 252

1.86

4.86

3.98e-15

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022625

Cytosolic large ribosomal subunit

9 of 106

2.19

6.47

4.13e-16

GO:0005840

Ribosome

10 of 276

1.82

4.72

2.52e-15

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4500

GTP hydrolysis and joining of the 60S ribosomal subunit

10 of 70

2.42

8.76

2.67e-20

CL:4521

Ribosome

8 of 33

2.64

8.6

3.98e-18

CL:4524

Ribosome

7 of 27

2.67

7.59

9.41e-16

CL:4429

GTP hydrolysis and joining of the 60S ribosomal subunit

11 of 152

2.12

7.35

2.67e-20

CL:4525

Cytosolic large ribosomal subunit

6 of 15

2.86

7.07

3.69e-14

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lav03010

Ribosome

9 of 125

2.12

6.22

3.67e-16

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

9 of 177

1.97

5.08

3.87e-14

MAP-975956

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

9 of 182

1.95

5.03

3.87e-14

MAP-72689

Formation of a pool of free 40S subunits

9 of 184

1.95

5.01

3.87e-14

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

9 of 188

1.94

4.98

3.87e-14

MAP-156827

L13a-mediated translational silencing of Ceruloplasmin expression

9 of 201

1.91

4.86

3.87e-14

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022626

Cytosolic ribosome

7 of 112

2.06

4.41

5.79e-11

GOCC:0005840

Ribosome

8 of 216

1.83

3.82

5.66e-11

GOCC:0022625

Cytosolic large ribosomal subunit

4 of 44

2.22

2.77

3.11e-06

GOCC:0044391

Ribosomal subunit

5 of 165

1.74

2.25

5.03e-06

GOCC:1990904

Ribonucleoprotein complex

7 of 510

1.4

1.86

1.21e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

6 of 81

2.13

4.14

8.84e-10

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00428

60s Acidic ribosomal protein

2 of 7

2.72

0.92

0.0213

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR038716

Ribosomal protein P1/P2, N-terminal domain

2 of 6

2.78

0.86

0.0279

IPR027534

Ribosomal protein L12/P1/P2 family

2 of 4

2.96

0.86

0.0279

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