Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sdhASuccinate dehydrogenase flavoprotein subunit. (548 aa)    
Predicted Functional Partners:
sucC
succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.997
sucD
succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.996
lutA_1
Lactate utilization protein A.
 
  
 0.995
ndhI_5
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic.
  
 0.976
ttdB_1
L(+)-tartrate dehydratase subunit beta.
  
 
 0.970
ttdB_2
L(+)-tartrate dehydratase subunit beta.
  
 
 0.968
ttdA_1
L(+)-tartrate dehydratase subunit alpha.
  
 
 0.968
ttdA_2
L(+)-tartrate dehydratase subunit alpha.
  
 
 0.968
gltA_2
Citrate synthase; Belongs to the citrate synthase family.
  
 0.964
bclA
benzoate--CoA ligase.
  
 0.960
Your Current Organism:
Methanobrevibacter cuticularis
NCBI taxonomy Id: 47311
Other names: DSM 11139, M. cuticularis, strain RFM-1
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