node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDQ73069.1 | SDQ98118.1 | SAMN04489765_1612 | SAMN04489765_2617 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP dehydrogenase. | 0.935 |
SDQ73069.1 | SDR18852.1 | SAMN04489765_1612 | SAMN04489765_3710 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP dehydrogenase. | 0.828 |
SDQ73069.1 | SDR25342.1 | SAMN04489765_1612 | SAMN04489765_4251 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.913 |
SDQ73069.1 | guaA | SAMN04489765_1612 | SAMN04489765_3706 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.977 |
SDQ73069.1 | guaB | SAMN04489765_1612 | SAMN04489765_3711 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.941 |
SDQ73069.1 | purA | SAMN04489765_1612 | SAMN04489765_4279 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.753 |
SDQ73069.1 | purH | SAMN04489765_1612 | SAMN04489765_3892 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP cyclohydrolase. | 0.498 |
SDQ93828.1 | SDQ97687.1 | SAMN04489765_2423 | SAMN04489765_2598 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Putative hydrolase of the HAD superfamily. | 0.699 |
SDQ93828.1 | SDQ98118.1 | SAMN04489765_2423 | SAMN04489765_2617 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | IMP dehydrogenase. | 0.954 |
SDQ93828.1 | SDR18852.1 | SAMN04489765_2423 | SAMN04489765_3710 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | IMP dehydrogenase. | 0.891 |
SDQ93828.1 | SDR25342.1 | SAMN04489765_2423 | SAMN04489765_4251 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.912 |
SDQ93828.1 | guaA | SAMN04489765_2423 | SAMN04489765_3706 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.932 |
SDQ93828.1 | guaB | SAMN04489765_2423 | SAMN04489765_3711 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.955 |
SDQ93828.1 | purA | SAMN04489765_2423 | SAMN04489765_4279 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.922 |
SDQ93828.1 | purH | SAMN04489765_2423 | SAMN04489765_3892 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | IMP cyclohydrolase. | 0.920 |
SDQ97687.1 | SDQ93828.1 | SAMN04489765_2598 | SAMN04489765_2423 | Putative hydrolase of the HAD superfamily. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.699 |
SDQ97687.1 | SDQ98118.1 | SAMN04489765_2598 | SAMN04489765_2617 | Putative hydrolase of the HAD superfamily. | IMP dehydrogenase. | 0.697 |
SDQ97687.1 | SDR18852.1 | SAMN04489765_2598 | SAMN04489765_3710 | Putative hydrolase of the HAD superfamily. | IMP dehydrogenase. | 0.697 |
SDQ97687.1 | guaA | SAMN04489765_2598 | SAMN04489765_3706 | Putative hydrolase of the HAD superfamily. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.724 |
SDQ97687.1 | guaB | SAMN04489765_2598 | SAMN04489765_3711 | Putative hydrolase of the HAD superfamily. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.705 |