STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
disADiadenylate cyclase; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. (361 aa)    
Predicted Functional Partners:
radA
DNA repair protein RadA/Sms; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.980
SDR24954.1
Hypothetical protein.
     
 0.866
SDQ82301.1
Phosphoesterase RecJ domain-containing protein.
  
   
 0.739
SDR09259.1
Transcription regulator of the Arc/MetJ class.
  
     0.734
ispD
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
  
    0.709
SDR24944.1
Transcriptional regulator, CarD family.
 
     0.671
SDR15503.1
DNA helicase-2 / ATP-dependent DNA helicase PcrA; Belongs to the helicase family. UvrD subfamily.
   
    0.639
SDR15522.1
Superfamily I DNA or RNA helicase; Belongs to the helicase family. UvrD subfamily.
   
    0.639
ispF
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
  
    0.608
SDR10054.1
EDD domain protein, DegV family.
  
    0.488
Your Current Organism:
Tsukamurella pulmonis
NCBI taxonomy Id: 47312
Other names: ATCC 700081, CCUG 35732, CIP 104791, DSM 44142, DSM 44990 [[Tsukamurella spongiae]], JCM 10111, JCM 14882 [[Tsukamurella spongiae]], NCTC 13230, NRRL B-24467 [[Tsukamurella spongiae]], T. pulmonis, Tsukamurella sp. K362, Tsukamurella spongiae, Tsukamurella spongiae Olson et al. 2007, strain K362 [[Tsukamurella spongiae]]
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