A0A2H3CVL8 protein (Armillaria gallica) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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A0A2H3CVL8

Piwi-domain-containing protein. (829 aa)

Predicted Functional Partners:

A0A2H3CUA3

0.803

A0A2H3CWM7

0.803

A0A2H3EAF8

0.794

A0A2H3EEF1

0.794

A0A2H3EEP0

0.794

A0A2H3EPY1

0.794

A0A2H3EA67

0.752

A0A2H3DYL1

0.743

A0A2H3ED83

0.724

A0A2H3E9I1

0.723

Your Current Organism:

Armillaria gallica

NCBI taxonomy Id: 47427
Other names: A. gallica, Armillaria bulbosa, Armillaria lutea

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2H3CUA3	A0A2H3CVL8	Ribonuclease III.	Piwi-domain-containing protein.	0.803
A0A2H3CVL8	A0A2H3CUA3	Piwi-domain-containing protein.	Ribonuclease III.	0.803
A0A2H3CVL8	A0A2H3CWM7	Piwi-domain-containing protein.	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the helicase family. Dicer subfamily.	0.803
A0A2H3CVL8	A0A2H3DYL1	Piwi-domain-containing protein.	Uncharacterized protein.	0.743
A0A2H3CVL8	A0A2H3E9I1	Piwi-domain-containing protein.	ARM repeat-containing protein.	0.723
A0A2H3CVL8	A0A2H3EA67	Piwi-domain-containing protein.	Uncharacterized protein.	0.752
A0A2H3CVL8	A0A2H3EAF8	Piwi-domain-containing protein.	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the helicase family. Dicer subfamily.	0.794
A0A2H3CVL8	A0A2H3ED83	Piwi-domain-containing protein.	Ribonuclease III.	0.724
A0A2H3CVL8	A0A2H3EEF1	Piwi-domain-containing protein.	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the helicase family. Dicer subfamily.	0.794
A0A2H3CVL8	A0A2H3EEP0	Piwi-domain-containing protein.	Ribonuclease III.	0.794
A0A2H3CVL8	A0A2H3EPY1	Piwi-domain-containing protein.	Uncharacterized protein.	0.794
A0A2H3CWM7	A0A2H3CVL8	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the helicase family. Dicer subfamily.	Piwi-domain-containing protein.	0.803
A0A2H3DYL1	A0A2H3CVL8	Uncharacterized protein.	Piwi-domain-containing protein.	0.743
A0A2H3E9I1	A0A2H3CVL8	ARM repeat-containing protein.	Piwi-domain-containing protein.	0.723
A0A2H3EA67	A0A2H3CVL8	Uncharacterized protein.	Piwi-domain-containing protein.	0.752
A0A2H3EAF8	A0A2H3CVL8	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the helicase family. Dicer subfamily.	Piwi-domain-containing protein.	0.794
A0A2H3ED83	A0A2H3CVL8	Ribonuclease III.	Piwi-domain-containing protein.	0.724
A0A2H3EEF1	A0A2H3CVL8	P-loop containing nucleoside triphosphate hydrolase protein; Belongs to the helicase family. Dicer subfamily.	Piwi-domain-containing protein.	0.794
A0A2H3EEP0	A0A2H3CVL8	Ribonuclease III.	Piwi-domain-containing protein.	0.794
A0A2H3EPY1	A0A2H3CVL8	Uncharacterized protein.	Piwi-domain-containing protein.	0.794

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.915

expected number of edges:

19

PPI enrichment p-value:

1.05e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098662

Inorganic cation transmembrane transport

10 of 176

1.78

4.33

3.20e-14

GO:0042776

Proton motive force-driven mitochondrial ATP synthesis

3 of 3

3.02

3.29

1.01e-06

GO:0006810

Transport

11 of 1358

0.93

1.1

6.24e-09

GO:0030003

Cellular cation homeostasis

3 of 97

1.51

1.03

0.0053

GO:0098771

Inorganic ion homeostasis

3 of 109

1.46

0.97

0.0068

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

7 of 12

2.79

7.44

4.47e-15

GO:0015078

Proton transmembrane transporter activity

8 of 86

1.99

4.87

4.78e-13

GO:0019829

ATPase-coupled cation transmembrane transporter activity

7 of 63

2.07

4.69

1.05e-11

GO:0022890

Inorganic cation transmembrane transporter activity

10 of 193

1.74

4.23

1.18e-14

GO:0009678

Pyrophosphate hydrolysis-driven proton transmembrane transporter activity

5 of 44

2.08

3.45

3.56e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033178

Proton-transporting two-sector ATPase complex, catalytic domain

6 of 17

2.57

5.58

1.11e-11

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

6 of 17

2.57

5.58

1.11e-11

GO:0000275

Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

5 of 8

2.82

5.45

5.51e-11

GO:0016469

Proton-transporting two-sector ATPase complex

7 of 55

2.13

4.82

1.11e-11

GO:0005754

Mitochondrial proton-transporting ATP synthase, catalytic core

4 of 5

2.93

4.43

6.39e-09

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8347

Proton-transporting ATP synthase complex

6 of 14

2.65

5.72

8.65e-12

CL:8333

Proton-transporting two-sector ATPase complex

7 of 59

2.1

4.63

2.47e-11

CL:8352

Proton channel activity

3 of 5

2.8

2.76

8.32e-06

CL:13508

Copper ion transport

2 of 6

2.55

1.3

0.0042

CL:13238

Mixed, incl. Cation homeostasis, and Lipid transport

4 of 174

1.38

1.04

0.0033

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

8 of 143

1.77

3.77

1.58e-11

map04016

MAPK signaling pathway - plant

2 of 7

2.48

1.45

0.0021

map01100

Metabolic pathways

8 of 2025

0.62

0.46

0.0042

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-936837

Ion transport by P-type ATPases

3 of 29

2.04

1.31

0.0030

MAP-983712

Ion channel transport

3 of 62

1.71

0.94

0.0128

MAP-1852241

Organelle biogenesis and maintenance

3 of 68

1.67

0.93

0.0128

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

3 of 75

1.62

0.92

0.0128

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

6 of 13

2.69

5.93

3.63e-12

GOCC:0016020

Membrane

11 of 1420

0.91

1.05

1.91e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0139

CF(1)

5 of 6

2.94

5.66

2.89e-11

KW-0066

ATP synthesis

5 of 6

2.94

5.66

2.89e-11

KW-0375

Hydrogen ion transport

3 of 22

2.16

2.12

6.86e-05

KW-0067

ATP-binding

8 of 418

1.3

1.88

3.68e-08

KW-1278

Translocase

2 of 26

1.91

1.02

0.0104

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02874

ATP synthase alpha/beta family, beta-barrel domain

5 of 7

2.88

5.14

2.50e-10

PF00122

E1-E2 ATPase

4 of 28

2.18

2.53

9.30e-06

PF00702

Haloacid dehalogenase-like hydrolase

3 of 14

2.35

1.99

0.00017

PF00006

ATP synthase alpha/beta family, nucleotide-binding domain

2 of 4

2.72

1.34

0.0037

PF00403

Heavy-metal-associated domain

2 of 6

2.55

1.24

0.0055

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036121

ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily

5 of 6

2.94

5.06

4.16e-10

IPR020003

ATPase, alpha/beta subunit, nucleotide-binding domain, active site

5 of 7

2.88

5.03

4.16e-10

IPR004100

ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain

5 of 7

2.88

5.03

4.16e-10

IPR000194

ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain

5 of 7

2.88

5.03

4.16e-10

IPR005722

ATP synthase, F1 complex, beta subunit

3 of 3

3.02

2.78

8.67e-06

(more ...)

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