A0A2H3CZ64 protein (Armillaria gallica) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A2H3CZ64

Alpha/beta-hydrolase. (339 aa)

Predicted Functional Partners:

A0A2H3DJQ2

0.422

A0A2H3CV26

0.418

A0A2H3E8N0

0.415

Your Current Organism:

Armillaria gallica

NCBI taxonomy Id: 47427
Other names: A. gallica, Armillaria bulbosa, Armillaria lutea

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2H3CV26	A0A2H3CZ64	Long-chain-fatty-acid-CoA-ligase.	Alpha/beta-hydrolase.	0.418
A0A2H3CV26	A0A2H3DJQ2	Long-chain-fatty-acid-CoA-ligase.	LACT-domain-containing protein.	0.488
A0A2H3CV26	A0A2H3E8N0	Long-chain-fatty-acid-CoA-ligase.	Uncharacterized protein.	0.743
A0A2H3CZ64	A0A2H3CV26	Alpha/beta-hydrolase.	Long-chain-fatty-acid-CoA-ligase.	0.418
A0A2H3CZ64	A0A2H3DJQ2	Alpha/beta-hydrolase.	LACT-domain-containing protein.	0.422
A0A2H3CZ64	A0A2H3E8N0	Alpha/beta-hydrolase.	Uncharacterized protein.	0.415
A0A2H3DJQ2	A0A2H3CV26	LACT-domain-containing protein.	Long-chain-fatty-acid-CoA-ligase.	0.488
A0A2H3DJQ2	A0A2H3CZ64	LACT-domain-containing protein.	Alpha/beta-hydrolase.	0.422
A0A2H3DJQ2	A0A2H3E8N0	LACT-domain-containing protein.	Uncharacterized protein.	0.809
A0A2H3E8N0	A0A2H3CV26	Uncharacterized protein.	Long-chain-fatty-acid-CoA-ligase.	0.743
A0A2H3E8N0	A0A2H3CZ64	Uncharacterized protein.	Alpha/beta-hydrolase.	0.415
A0A2H3E8N0	A0A2H3DJQ2	Uncharacterized protein.	LACT-domain-containing protein.	0.809

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.527

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007178

Transmembrane receptor protein serine/threonine kinase signaling pathway

7 of 25

2.57

6.39

1.82e-13

GO:0090092

Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

5 of 22

2.48

4.16

7.65e-09

GO:0007166

Cell surface receptor signaling pathway

8 of 290

1.56

2.63

6.65e-09

GO:0009967

Positive regulation of signal transduction

6 of 144

1.74

2.57

4.33e-07

GO:0090100

Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

3 of 8

2.69

2.55

1.97e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008083

Growth factor activity

4 of 8

2.82

3.7

1.42e-07

GO:0004675

Transmembrane receptor protein serine/threonine kinase activity

3 of 6

2.82

2.75

8.76e-06

GO:0005125

Cytokine activity

2 of 8

2.52

1.27

0.0047

GO:0005488

Binding

11 of 5714

0.4

0.32

0.0064

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098802

Plasma membrane signaling receptor complex

3 of 31

2.11

1.43

0.0018

GO:0005615

Extracellular space

4 of 180

1.47

1.07

0.0036

GO:1902554

Serine/threonine protein kinase complex

2 of 27

1.99

0.79

0.0327

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25879787

(2015) TGF-beta superfamily members from the helminth Fasciola hepatica show intrinsic effects on viability and development.

3 of 5

2.9

2.52

2.54e-05

PMID:36701396

(2023) A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance.

2 of 11

2.38

0.85

0.0284

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4608

Transmembrane receptor protein serine/threonine kinase signaling pathway, and Noggin

7 of 26

2.55

6.49

9.64e-14

CL:4610

Transmembrane receptor protein serine/threonine kinase signaling pathway

5 of 18

2.56

4.63

1.07e-09

CL:4611

Transmembrane receptor protein serine/threonine kinase signaling pathway

3 of 13

2.48

2.27

5.56e-05

CL:1127

Mixed, incl. Small GTPase Rho, and Peptidyl-threonine modification

3 of 33

2.08

1.65

0.00060

CL:4650

Noggin, and Kazal domain

2 of 5

2.72

1.45

0.0023

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04350

TGF-beta signaling pathway

4 of 46

2.06

2.53

6.14e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9006936

Signaling by TGFB family members

4 of 46

2.06

2.15

4.78e-05

MAP-1502540

Signaling by Activin

2 of 3

2.94

1.39

0.0031

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098802

Plasma membrane signaling receptor complex

3 of 27

2.17

1.51

0.0013

GOCC:0005887

Integral component of plasma membrane

3 of 58

1.83

1.22

0.0037

GOCC:1902554

Serine/threonine protein kinase complex

2 of 39

1.83

0.7

0.0455

GOCC:0005576

Extracellular region

3 of 162

1.39

0.67

0.0361

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0339

Growth factor

3 of 4

3.0

3.04

2.85e-06

KW-0964

Secreted

3 of 19

2.32

2.2

6.23e-05

KW-0723

Serine/threonine-protein kinase

3 of 59

1.83

1.46

0.0010

KW-1015

Disulfide bond

3 of 184

1.33

0.75

0.0203

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015615

Transforming growth factor-beta-related

2 of 2

3.12

1.32

0.0042

IPR001839

Transforming growth factor-beta, C-terminal

2 of 3

2.94

1.31

0.0042

IPR029034

Cystine-knot cytokine

2 of 5

2.72

1.27

0.0049

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00204

Transforming growth factor-beta (TGF-beta) family

3 of 4

3.0

2.92

4.78e-06

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