A0A2H3DHG0 protein (Armillaria gallica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A2H3DHG0

Di-copper centre-containing protein. (320 aa)

Predicted Functional Partners:

A0A2H3E8H0

0.676

A0A2H3EQ88

0.653

A0A2H3CQ09

0.625

A0A2H3E3H3

0.625

A0A2H3D1Q0

0.623

A0A2H3DK47

0.622

A0A2H3E7P5

0.603

A0A2H3E1U1

0.569

A0A2H3E815

0.564

A0A2H3ES32

0.564

Your Current Organism:

Armillaria gallica

NCBI taxonomy Id: 47427
Other names: A. gallica, Armillaria bulbosa, Armillaria lutea

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2H3CQ09	A0A2H3DHG0	ANK_REP_REGION domain-containing protein.	Di-copper centre-containing protein.	0.625
A0A2H3CQ09	A0A2H3E1U1	ANK_REP_REGION domain-containing protein.	Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family.	0.674
A0A2H3CQ09	A0A2H3E3H3	ANK_REP_REGION domain-containing protein.	Ankyrin.	0.640
A0A2H3CQ09	A0A2H3E7P5	ANK_REP_REGION domain-containing protein.	Mov34-domain-containing protein.	0.648
A0A2H3CQ09	A0A2H3E815	ANK_REP_REGION domain-containing protein.	Tyosinase_C domain-containing protein.	0.490
A0A2H3CQ09	A0A2H3E8H0	ANK_REP_REGION domain-containing protein.	Di-copper centre-containing protein.	0.625
A0A2H3CQ09	A0A2H3ES32	ANK_REP_REGION domain-containing protein.	Tyrosinase.	0.490
A0A2H3D1Q0	A0A2H3DHG0	Di-copper centre-containing protein.	Di-copper centre-containing protein.	0.623
A0A2H3D1Q0	A0A2H3E815	Di-copper centre-containing protein.	Tyosinase_C domain-containing protein.	0.668
A0A2H3D1Q0	A0A2H3E8H0	Di-copper centre-containing protein.	Di-copper centre-containing protein.	0.696
A0A2H3D1Q0	A0A2H3ES32	Di-copper centre-containing protein.	Tyrosinase.	0.668
A0A2H3DHG0	A0A2H3CQ09	Di-copper centre-containing protein.	ANK_REP_REGION domain-containing protein.	0.625
A0A2H3DHG0	A0A2H3D1Q0	Di-copper centre-containing protein.	Di-copper centre-containing protein.	0.623
A0A2H3DHG0	A0A2H3DK47	Di-copper centre-containing protein.	Di-copper centre-containing protein.	0.622
A0A2H3DHG0	A0A2H3E1U1	Di-copper centre-containing protein.	Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family.	0.569
A0A2H3DHG0	A0A2H3E3H3	Di-copper centre-containing protein.	Ankyrin.	0.625
A0A2H3DHG0	A0A2H3E7P5	Di-copper centre-containing protein.	Mov34-domain-containing protein.	0.603
A0A2H3DHG0	A0A2H3E815	Di-copper centre-containing protein.	Tyosinase_C domain-containing protein.	0.564
A0A2H3DHG0	A0A2H3E8H0	Di-copper centre-containing protein.	Di-copper centre-containing protein.	0.676
A0A2H3DHG0	A0A2H3EQ88	Di-copper centre-containing protein.	Aspartate aminotransferase.	0.653

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

16

PPI enrichment p-value:

1.33e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042273

Ribosomal large subunit biogenesis

10 of 77

1.98

5.59

4.57e-16

GO:0000470

Maturation of LSU-rRNA

7 of 41

2.09

4.54

4.47e-11

GO:0000463

Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

6 of 30

2.16

4.16

1.09e-09

GO:0042254

Ribosome biogenesis

11 of 274

1.47

2.94

1.49e-13

GO:0006364

rRNA processing

9 of 204

1.51

2.73

1.85e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043021

Ribonucleoprotein complex binding

3 of 41

1.73

0.75

0.0338

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030687

Preribosome, large subunit precursor

9 of 35

2.27

7.01

7.92e-17

GO:0005730

Nucleolus

11 of 215

1.57

3.56

2.69e-15

GO:0005654

Nucleoplasm

4 of 211

1.14

0.77

0.0085

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4695

Preribosome, large subunit precursor, and Ribosomal large subunit export from nucleus

10 of 28

2.42

8.78

2.32e-20

CL:4698

Preribosome, large subunit precursor, and ATPase binding

9 of 21

2.49

8.61

4.01e-19

CL:4684

Preribosome, large subunit precursor, and DEAD/DEAH box helicase domain

11 of 63

2.1

7.28

2.32e-20

CL:4723

Mixed, incl. Circularly permuted (CP)-type guanine nucleotide-binding (G) domain, and ATPase binding

3 of 6

2.56

2.59

1.45e-05

CL:4700

Maturation of LSU-rRNA, and PUA domain

3 of 10

2.34

2.27

4.62e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

6 of 134

1.51

1.86

9.99e-06

MAP-8868773

rRNA processing in the nucleus and cytosol

6 of 138

1.5

1.84

9.99e-06

MAP-72312

rRNA processing

6 of 141

1.49

1.83

9.99e-06

MAP-8953854

Metabolism of RNA

7 of 553

0.96

0.85

0.00046

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030687

Preribosome, large subunit precursor

3 of 22

2.0

1.6

0.00067

GOCC:0031981

Nuclear lumen

8 of 457

1.11

1.2

1.58e-05

GOCC:0005730

Nucleolus

3 of 98

1.35

0.67

0.0345

GOCC:0005634

Nucleus

9 of 1134

0.76

0.66

0.00023

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0690

Ribosome biogenesis

4 of 18

2.21

2.77

3.05e-06

KW-0698

rRNA processing

3 of 17

2.11

1.85

0.00024

KW-0539

Nucleus

5 of 273

1.13

0.94

0.0014

KW-0489

Methyltransferase

2 of 30

1.69

0.69

0.0458

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030378

Circularly permuted (CP)-type guanine nucleotide-binding (G) domain

2 of 2

2.86

0.89

0.0247

IPR023179

GTP-binding protein, orthogonal bundle domain superfamily

2 of 3

2.69

0.89

0.0247

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About