A0A2H3E3P2 protein (Armillaria gallica) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

A0A2H3E3P2

Collagen_bind_2 domain-containing protein. (373 aa)

Predicted Functional Partners:

A0A2H3CQF4

0.916

A0A2H3D8U7

0.836

A0A2H3DRL5

0.836

A0A2H3DVI4

0.836

A0A2H3DPB7

0.833

A0A2H3DNL9

0.832

A0A2H3CLX5

0.824

A0A2H3EGF4

0.817

A0A2H3D0W7

0.813

A0A2H3E0Q6

0.803

Your Current Organism:

Armillaria gallica

NCBI taxonomy Id: 47427
Other names: A. gallica, Armillaria bulbosa, Armillaria lutea

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2H3CLX5	A0A2H3CQF4	Uncharacterized protein.	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	0.994
A0A2H3CLX5	A0A2H3E3P2	Uncharacterized protein.	Collagen_bind_2 domain-containing protein.	0.824
A0A2H3CQF4	A0A2H3CLX5	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.994
A0A2H3CQF4	A0A2H3D0W7	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Small nuclear ribonucleoprotein Sm D3.	0.722
A0A2H3CQF4	A0A2H3D8U7	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Ribosomal protein S12/S23; Belongs to the universal ribosomal protein uS12 family.	0.484
A0A2H3CQF4	A0A2H3DNL9	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	RNA-binding domain-containing protein.	0.562
A0A2H3CQF4	A0A2H3DRL5	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Ribosomal protein S12; Belongs to the universal ribosomal protein uS12 family.	0.484
A0A2H3CQF4	A0A2H3DVI4	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.420
A0A2H3CQF4	A0A2H3E0Q6	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Nuclear cap-binding protein subunit 2.	0.727
A0A2H3CQF4	A0A2H3E3P2	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Collagen_bind_2 domain-containing protein.	0.916
A0A2H3CQF4	A0A2H3EGF4	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	Ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	0.651
A0A2H3D0W7	A0A2H3CQF4	Small nuclear ribonucleoprotein Sm D3.	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	0.722
A0A2H3D0W7	A0A2H3DNL9	Small nuclear ribonucleoprotein Sm D3.	RNA-binding domain-containing protein.	0.833
A0A2H3D0W7	A0A2H3DVI4	Small nuclear ribonucleoprotein Sm D3.	Uncharacterized protein.	0.831
A0A2H3D0W7	A0A2H3E0Q6	Small nuclear ribonucleoprotein Sm D3.	Nuclear cap-binding protein subunit 2.	0.991
A0A2H3D0W7	A0A2H3E3P2	Small nuclear ribonucleoprotein Sm D3.	Collagen_bind_2 domain-containing protein.	0.813
A0A2H3D8U7	A0A2H3CQF4	Ribosomal protein S12/S23; Belongs to the universal ribosomal protein uS12 family.	DEAD-domain-containing protein; Belongs to the DEAD box helicase family.	0.484
A0A2H3D8U7	A0A2H3DNL9	Ribosomal protein S12/S23; Belongs to the universal ribosomal protein uS12 family.	RNA-binding domain-containing protein.	0.640
A0A2H3D8U7	A0A2H3DPB7	Ribosomal protein S12/S23; Belongs to the universal ribosomal protein uS12 family.	Uncharacterized protein.	0.991
A0A2H3D8U7	A0A2H3E3P2	Ribosomal protein S12/S23; Belongs to the universal ribosomal protein uS12 family.	Collagen_bind_2 domain-containing protein.	0.836

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Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.881

expected number of edges:

13

PPI enrichment p-value:

0.000854

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32038701

(2019) The Genetic Architecture of Early Body Temperature and Its Correlation With Salmonella Pullorum Resistance in Three Chicken Breeds.

6 of 12

2.88

5.61

3.10e-11

PMID:35159260

(2022) TRIM32 Deficiency Impairs the Generation of Pyramidal Neurons in Developing Cerebral Cortex.

3 of 18

2.41

0.99

0.0156

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5706

Mixed, incl. Function to find, and U1-C, C2H2-type zinc finger

5 of 5

3.18

5.68

3.98e-11

CL:14337

Delta serrate ligand, and Domain of unknown function

2 of 6

2.71

0.93

0.0207

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gga04120

Ubiquitin mediated proteolysis

4 of 121

1.7

1.71

0.00015

gga04330

Notch signaling pathway

2 of 46

1.82

0.75

0.0359

gga04137

Mitophagy - animal

2 of 55

1.74

0.74

0.0359

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

GGA-1980143

Signaling by NOTCH1

6 of 16

2.76

6.15

1.75e-12

GGA-2122948

Activated NOTCH1 Transmits Signal to the Nucleus

5 of 8

2.98

5.65

3.23e-11

GGA-1227888

Negative Regulation of MDA5 signaling

3 of 5

2.96

2.92

4.64e-06

GGA-1253288

Downregulation of ERBB4 signaling

3 of 7

2.82

2.78

7.95e-06

GGA-5610780

Degradation of GLI1 by the proteasome

3 of 8

2.76

2.73

9.11e-06

(more ...)

WikiPathways

pathway

description

count in network

strength

signal

false discovery rate

WP827

Delta-Notch signaling pathway

3 of 63

1.86

1.66

0.00036

WP798

Notch signaling pathway

2 of 30

2.01

1.26

0.0036

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0002193

MAML1-RBP-Jkappa- ICN1 complex

2 of 2

3.18

1.35

0.0037

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019956

Ubiquitin domain

2 of 3

3.01

1.07

0.0117

IPR019954

Ubiquitin conserved site

2 of 3

3.01

1.07

0.0117

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00213

Ubiquitin homologues

3 of 31

2.17

1.59

0.00092

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