STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SEM46318.1dTMP kinase. (217 aa)    
Predicted Functional Partners:
thyX
Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.985
tdk
Thymidine kinase.
  
 
 0.941
SEM67528.1
Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
  
 
 0.907
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
  
 
 0.898
SEN01011.1
dCMP deaminase.
    
 0.865
SEM57312.1
5'-nucleotidase; Belongs to the 5'-nucleotidase family.
   
 
  0.846
SEM84584.1
5'-deoxynucleotidase.
  
 
  0.845
coaX
Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
   
   0.825
SEM81332.1
Phosphoribosylformylglycinamidine synthase.
  
    0.792
SEM46338.1
Hypothetical protein.
       0.739
Your Current Organism:
Hydrogenoanaerobacterium saccharovorans
NCBI taxonomy Id: 474960
Other names: AS 1.5070, Clostridium sp. SW512, Clostridium sp. W72, H. saccharovorans, Hydrogenoanaerobacterium saccharovorans Song and Dong 2009, JCM 14861, strain SW512
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