node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SMC71601.1 | gcvP | SAMN04488101_102421 | SAMN04488101_103265 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.704 |
SMC71601.1 | gcvT | SAMN04488101_102421 | SAMN04488101_102271 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.628 |
SMC71601.1 | glyA | SAMN04488101_102421 | SAMN04488101_10393 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
SMC80405.1 | SMC94617.1 | SAMN04488101_103148 | SAMN04488101_106104 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glutamate synthase (NADPH/NADH) large chain. | 0.494 |
SMC80405.1 | folD | SAMN04488101_103148 | SAMN04488101_106220 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.931 |
SMC80405.1 | gcvP | SAMN04488101_103148 | SAMN04488101_103265 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.732 |
SMC80405.1 | gcvT | SAMN04488101_103148 | SAMN04488101_102271 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.933 |
SMC80405.1 | glyA | SAMN04488101_103148 | SAMN04488101_10393 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.972 |
SMC80405.1 | purH | SAMN04488101_103148 | SAMN04488101_1162 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.592 |
SMC80405.1 | purN | SAMN04488101_103148 | SAMN04488101_1116 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.594 |
SMC94617.1 | SMC80405.1 | SAMN04488101_106104 | SAMN04488101_103148 | Glutamate synthase (NADPH/NADH) large chain. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.494 |
SMC94617.1 | folD | SAMN04488101_106104 | SAMN04488101_106220 | Glutamate synthase (NADPH/NADH) large chain. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.472 |
SMC94617.1 | gcvH | SAMN04488101_106104 | SAMN04488101_103116 | Glutamate synthase (NADPH/NADH) large chain. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.951 |
SMC94617.1 | gcvP | SAMN04488101_106104 | SAMN04488101_103265 | Glutamate synthase (NADPH/NADH) large chain. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.956 |
SMC94617.1 | gcvT | SAMN04488101_106104 | SAMN04488101_102271 | Glutamate synthase (NADPH/NADH) large chain. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.956 |
SMC94617.1 | glyA | SAMN04488101_106104 | SAMN04488101_10393 | Glutamate synthase (NADPH/NADH) large chain. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.951 |
SMC94617.1 | purH | SAMN04488101_106104 | SAMN04488101_1162 | Glutamate synthase (NADPH/NADH) large chain. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.940 |
SMC94617.1 | purL | SAMN04488101_106104 | SAMN04488101_10468 | Glutamate synthase (NADPH/NADH) large chain. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.954 |
folD | SMC80405.1 | SAMN04488101_106220 | SAMN04488101_103148 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.931 |
folD | SMC94617.1 | SAMN04488101_106220 | SAMN04488101_106104 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glutamate synthase (NADPH/NADH) large chain. | 0.472 |