| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| accD | cvpA | ICMP_042 | ICMP_044 | acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | Membrane protein required for colicin V production. | 0.563 |
| accD | folC | ICMP_042 | ICMP_043 | acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.859 |
| accD | prlC | ICMP_042 | ICMP_040 | acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | Oligopeptidase A. | 0.400 |
| accD | yhiQ | ICMP_042 | ICMP_041 | acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | Predicted SAM-dependent methyltransferase; Specifically methylates the guanosine in position 1516 of 16S rRNA. | 0.400 |
| cvpA | accD | ICMP_044 | ICMP_042 | Membrane protein required for colicin V production. | acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.563 |
| cvpA | folC | ICMP_044 | ICMP_043 | Membrane protein required for colicin V production. | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.578 |
| cvpA | yhiQ | ICMP_044 | ICMP_041 | Membrane protein required for colicin V production. | Predicted SAM-dependent methyltransferase; Specifically methylates the guanosine in position 1516 of 16S rRNA. | 0.410 |
| folC | accD | ICMP_043 | ICMP_042 | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.859 |
| folC | cvpA | ICMP_043 | ICMP_044 | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | Membrane protein required for colicin V production. | 0.578 |
| folC | prlC | ICMP_043 | ICMP_040 | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | Oligopeptidase A. | 0.403 |
| folC | yhiQ | ICMP_043 | ICMP_041 | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | Predicted SAM-dependent methyltransferase; Specifically methylates the guanosine in position 1516 of 16S rRNA. | 0.400 |
| prlC | accD | ICMP_040 | ICMP_042 | Oligopeptidase A. | acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.400 |
| prlC | folC | ICMP_040 | ICMP_043 | Oligopeptidase A. | Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.403 |
| prlC | sgaU | ICMP_040 | ICMP_039 | Oligopeptidase A. | L-xylulose 5-phosphate 3-epimerase like protein. | 0.470 |
| prlC | yhiQ | ICMP_040 | ICMP_041 | Oligopeptidase A. | Predicted SAM-dependent methyltransferase; Specifically methylates the guanosine in position 1516 of 16S rRNA. | 0.815 |
| rnpA | yhiQ | ICMP_013 | ICMP_041 | Ribonuclease P; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | Predicted SAM-dependent methyltransferase; Specifically methylates the guanosine in position 1516 of 16S rRNA. | 0.553 |
| rnpA | yidD | ICMP_013 | ICMP_012 | Ribonuclease P; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 0.973 |
| sgaU | prlC | ICMP_039 | ICMP_040 | L-xylulose 5-phosphate 3-epimerase like protein. | Oligopeptidase A. | 0.470 |
| sgaU | yhiQ | ICMP_039 | ICMP_041 | L-xylulose 5-phosphate 3-epimerase like protein. | Predicted SAM-dependent methyltransferase; Specifically methylates the guanosine in position 1516 of 16S rRNA. | 0.470 |
| yhiQ | accD | ICMP_041 | ICMP_042 | Predicted SAM-dependent methyltransferase; Specifically methylates the guanosine in position 1516 of 16S rRNA. | acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.400 |