| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| apt | gmk | ICMP_339 | ICMP_654 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.957 |
| apt | guaA | ICMP_339 | ICMP_077 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | 0.996 |
| apt | guaB | ICMP_339 | ICMP_076 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inositol-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.688 |
| apt | hpt | ICMP_339 | ICMP_218 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.934 |
| apt | pyrG | ICMP_339 | ICMP_131 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.409 |
| argS | gmk | ICMP_610 | ICMP_654 | arginyl-tRNA synthetase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.414 |
| argS | guaA | ICMP_610 | ICMP_077 | arginyl-tRNA synthetase. | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | 0.989 |
| argS | lysS | ICMP_610 | ICMP_148 | arginyl-tRNA synthetase. | Lysine tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.833 |
| argS | pyrG | ICMP_610 | ICMP_131 | arginyl-tRNA synthetase. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.788 |
| argS | rplA | ICMP_610 | ICMP_528 | arginyl-tRNA synthetase. | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.434 |
| argS | rplK | ICMP_610 | ICMP_529 | arginyl-tRNA synthetase. | 50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.470 |
| gmk | apt | ICMP_654 | ICMP_339 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.957 |
| gmk | argS | ICMP_654 | ICMP_610 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | arginyl-tRNA synthetase. | 0.414 |
| gmk | guaA | ICMP_654 | ICMP_077 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | 0.970 |
| gmk | guaB | ICMP_654 | ICMP_076 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Inositol-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.632 |
| gmk | hpt | ICMP_654 | ICMP_218 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.924 |
| gmk | pyrG | ICMP_654 | ICMP_131 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.407 |
| guaA | apt | ICMP_077 | ICMP_339 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.996 |
| guaA | argS | ICMP_077 | ICMP_610 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | arginyl-tRNA synthetase. | 0.989 |
| guaA | gmk | ICMP_077 | ICMP_654 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.970 |
STRING v12.5 is now available!
