| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| folP | pabC | ICMP_288 | ICMP_368 | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 4-amino-4-deoxychorismate lyase. | 0.935 |
| folP | thrA | ICMP_288 | ICMP_307 | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Bifunctional aspartokinase I/homeserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.592 |
| hisI | ilvD | ICMP_469 | ICMP_036 | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.630 |
| hisI | ilvI | ICMP_469 | ICMP_405 | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | Acetolactate synthase III large subunit. | 0.497 |
| hisI | leuA | ICMP_469 | ICMP_406 | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.529 |
| hisI | pabA | ICMP_469 | ICMP_243 | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | Para-aminobenzoate synthase component II. | 0.407 |
| hisI | pabB | ICMP_469 | ICMP_225 | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | Para-aminobenzoate synthase component I. | 0.405 |
| hisI | pabC | ICMP_469 | ICMP_368 | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | 4-amino-4-deoxychorismate lyase. | 0.716 |
| hisI | thrA | ICMP_469 | ICMP_307 | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | Bifunctional aspartokinase I/homeserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.840 |
| hisI | tyrA | ICMP_469 | ICMP_544 | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | Fused chorismate mutase T/prephenate dehydrogenase. | 0.487 |
| ilvD | hisI | ICMP_036 | ICMP_469 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | 0.630 |
| ilvD | ilvI | ICMP_036 | ICMP_405 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Acetolactate synthase III large subunit. | 0.944 |
| ilvD | leuA | ICMP_036 | ICMP_406 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.982 |
| ilvD | pabC | ICMP_036 | ICMP_368 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 4-amino-4-deoxychorismate lyase. | 0.865 |
| ilvD | thrA | ICMP_036 | ICMP_307 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Bifunctional aspartokinase I/homeserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.799 |
| ilvD | tyrA | ICMP_036 | ICMP_544 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Fused chorismate mutase T/prephenate dehydrogenase. | 0.491 |
| ilvI | hisI | ICMP_405 | ICMP_469 | Acetolactate synthase III large subunit. | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | 0.497 |
| ilvI | ilvD | ICMP_405 | ICMP_036 | Acetolactate synthase III large subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.944 |
| ilvI | leuA | ICMP_405 | ICMP_406 | Acetolactate synthase III large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.921 |
| ilvI | pabC | ICMP_405 | ICMP_368 | Acetolactate synthase III large subunit. | 4-amino-4-deoxychorismate lyase. | 0.709 |